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J Cancer 2024; 15(6):1511-1522. doi:10.7150/jca.91928 This issue Cite

Research Paper

High CD204+ tumor-associated macrophage density predicts a poor prognosis in patients with clear cell renal cell carcinoma

Yuxia Xie1*, Guojun Tang3*, Ping Xie1*, Xiao Zhao1, Chuhao Chen1, Xiaoyang Li1, Yongqiang Zhang1, Bo Wang2✉, Yun Luo1✉

1. Third Affiliated Hospital of Sun Yat-sen University, Department of Urology, Guangzhou, 510630, People's Republic of China.
2. Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Department of Urology, Guangzhou, 510120, People's Republic of China.
3. The First People's Hospital of Zhaoqing, Zhaoqing, 526000, People's Republic of China.
*These authors contributed equally to this work and shared first authorship.

✉ Corresponding authors: Bo Wang, Email wangb43sysu.edu.cn; Yun Luo, Email luoyun8sysu.edu.cn.

Citation:
Xie Y, Tang G, Xie P, Zhao X, Chen C, Li X, Zhang Y, Wang B, Luo Y. High CD204+ tumor-associated macrophage density predicts a poor prognosis in patients with clear cell renal cell carcinoma. J Cancer 2024; 15(6):1511-1522. doi:10.7150/jca.91928. https://www.jcancer.org/v15p1511.htm
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Abstract

Graphic abstract

Purpose: Tumor-associated macrophages (TAMs) play a crucial role in solid tumors and display varying characteristics depending on the specific tumor microenvironment (TME). The study investigated the presence and characteristics of TAMs in renal clear cell carcinoma (ccRCC) and assessed their influence on patient prognosis.

Methods: Immunohistochemistry (IHC) was used to identify CD204+ TAMs in a cohort of 72 patients with ccRCC. Kaplan-Meier survival analysis and log-rank test were used to evaluate the prognostic significance of CD204+ TAMs in each group. The TCGA-KIRC cohort was used to analyze the relationship between CD204 and immunity. The functions of CD204+ TAMs in the TCGA-KIRC cohort were analyzed through GO enrichment analysis. Immunofluorescence (IF) was conducted to confirm the positive effects of CD204 on regulatory T (Treg) cells and exhausted T (Tex) cells.

Results: There was a negative relation between high infiltration of CD204+ TAMs and both overall survival (OS) and progression-free survival (PFS) in ccRCC. A positive correlation was found between high-infiltrating CD204+ TAMs and distant organ metastasis, as well as lymph node metastasis. In the TCGA-KIRC cohort, the group with high expression of CD204 exhibited significant up-regulation of 120 genes as well as enrichment in the negative regulation of immunity. CD204 high-expression group showed up-regulation of Treg cells and Tex cells.

Conclusion: The presence of CD204+ TAMs in ccRCC is associated with a negative prognosis in patients. The high infiltration of CD204 promotes distant organ metastasis by aggerating Treg cells and Tex cells.

Keywords: CD204, Tumor-associated Macrophages, Clear cell renal cell carcinoma, Survival prognosis

Citation styles

APA
Xie, Y., Tang, G., Xie, P., Zhao, X., Chen, C., Li, X., Zhang, Y., Wang, B., Luo, Y. (2024). High CD204+ tumor-associated macrophage density predicts a poor prognosis in patients with clear cell renal cell carcinoma. Journal of Cancer, 15(6), 1511-1522. https://doi.org/10.7150/jca.91928.

ACS
Xie, Y.; Tang, G.; Xie, P.; Zhao, X.; Chen, C.; Li, X.; Zhang, Y.; Wang, B.; Luo, Y. High CD204+ tumor-associated macrophage density predicts a poor prognosis in patients with clear cell renal cell carcinoma. J. Cancer 2024, 15 (6), 1511-1522. DOI: 10.7150/jca.91928.

NLM
Xie Y, Tang G, Xie P, Zhao X, Chen C, Li X, Zhang Y, Wang B, Luo Y. High CD204+ tumor-associated macrophage density predicts a poor prognosis in patients with clear cell renal cell carcinoma. J Cancer 2024; 15(6):1511-1522. doi:10.7150/jca.91928. https://www.jcancer.org/v15p1511.htm

CSE
Xie Y, Tang G, Xie P, Zhao X, Chen C, Li X, Zhang Y, Wang B, Luo Y. 2024. High CD204+ tumor-associated macrophage density predicts a poor prognosis in patients with clear cell renal cell carcinoma. J Cancer. 15(6):1511-1522.

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