J Cancer 2017; 8(7):1263-1270. doi:10.7150/jca.17120

Research Paper

Cervical Cancers Manifest a High Rate of Infection by a High-Risk Human Papilloma Virus Subtype but a Very Low Rate of Infection by a Low-Risk Subtype in the Guiyang District of China

Juan Peng1, 2, Yan Yuan1, 3, Feng Shen1, Yan Wang1, Lichan Chen4, D. Joshua Liao5, Yujie Tan1, 6✉

1. Central Laboratory, Guizhou Medical University Hospital, Guiyang, Guizhou 550004, P. R. China;
2. Blood Transfusion Department, TaiHe Hospital Affiliated to HuBei University of Medicine, ShiYan, HuBei 442000, P. R. China;
3. Laboratory Medicine, People's Hospital of Guizhou Province, Guiyang, Guizhou 550002, P. R. China.
4. Hormel Institute, University of Minnesota, Austin, MN 55912, USA.
5. Department of Pathology, Guizhou Medical University Hospital, Guizhou 550004, P.R. China;
6. Laboratory Medicine, Baiyun Hospital Affiliated to Guizhou Medical University Hospital, Guiyang, Guizhou 550014, P. R. China.

Abstract

The prevalence of infection by different genotypes of human papillomavirus (HPV) varies among different geographic areas. We studied the prevalence of infection by 21 HPV genotypes in cervical tissue specimens from 4213 women in the Guiyang district, that is located in the southwest of China and is dominated by minor ethnicities of Chinese, and 2074 cases in our cohort had pathological diagnosis available. The overall infection rate was 36.98%. Most (72.08%) infectors were positive for only one HPV subtype, with the remaining being cases infected by two or more subtypes. Infections by the HPV subtypes 16, 52 and 58 were the most prevalent, having rates of 34.66%, 16.03%% and 15.53%, respectively. The most common cervical lesions in HPV infections were genital warts, cervical cancer (CC) and cervical intraepithelial neoplasia (CIN). Age and age at first sexual activity were independent risk factors for HPV infections that in turn cause certain cervical lesions. Intriguingly, while 94.90% of the CC patients were infected by oncogenically high-risk (HR) HPV subtypes, only 2.75% and 2.29% of these patients were infected by oncogenically low-risk (LR) subtypes or other-subtypes with their oncogenicity unclear. The rates of infection by LR-HPVs and other-HPVs were also low, being 4.63% and 6.76%, respectively, in the patients with CIN that is a precursor lesion of CC, lower than the 8.54% and 18.20%, respectively, in the women without a cervical lesion. Our data provides an important foundation for prevention, diagnosis and treatment of HPV infection in Guiyang district and suggests that development of vaccines for prevention and treatment of CC in this area should first target the HPV subtypes 16, 52 and 58, but not subtype 18 as for many other places. It deserves study whether infections by certain LR-HPVs and other-HPVs may serve as attenuated live vaccines for prevention of CC.

Keywords: Human Papillomavirus, Infection, Genotypes, epidemiology investigation.

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How to cite this article:
Peng J, Yuan Y, Shen F, Wang Y, Chen L, Liao DJ, Tan Y. Cervical Cancers Manifest a High Rate of Infection by a High-Risk Human Papilloma Virus Subtype but a Very Low Rate of Infection by a Low-Risk Subtype in the Guiyang District of China. J Cancer 2017; 8(7):1263-1270. doi:10.7150/jca.17120. Available from http://www.jcancer.org/v08p1263.htm