J Cancer 2017; 8(12):2336-2345. doi:10.7150/jca.19411 This issue Cite

Research Paper

Elevated expression of Derlin-1 associates with unfavorable survival time of squamous cell carcinoma of the head and neck and promotes its malignance

Leiming Pi1, Gangcai Zhu2, Li She1, Ming Wei1, Guancheng Liu1, Changhan Chen1, Di Hu1, Fusen Peng3, Haolei Tan4, Yong Liu1, Donghai Huang1, Yongquan Tian1, Xin Zhang1,✉

1. Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, Hunan, People's Republic of China
2. Department of Otolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University, 139 Renmin Road, Changsha 410010, Hunan, People's Republic of China
3. Department of Otolaryngology Head and Neck Surgery, Loudi Central Hospital, Loudi, Hunan, People's Republic of China
4. Department of Head and Neck Surgery, Hunan Cancer Hospital, The Affiliated Tumor Hospital of Xiangya Medical School, Central South University, 283 Tongzipo Road, Changsha, Hunan 410013, People's Republic of China

Citation:
Pi L, Zhu G, She L, Wei M, Liu G, Chen C, Hu D, Peng F, Tan H, Liu Y, Huang D, Tian Y, Zhang X. Elevated expression of Derlin-1 associates with unfavorable survival time of squamous cell carcinoma of the head and neck and promotes its malignance. J Cancer 2017; 8(12):2336-2345. doi:10.7150/jca.19411. https://www.jcancer.org/v08p2336.htm
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Abstract

Derlin-1 is over-expressed to function as an oncoprotein in breast, lung and colon cancers. However, the implications of Derlin-1 involved in squamous cell carcinoma of the head and neck (SCCHN) remain unknown. This study aims to investigate the effects of Derlin-1 expression on SCCHN tissues and cells. The potential mechanism of Derlin-1 regulating SCCHN cell proliferation, apoptosis and metastasis was also indicated in this work. Western blot and immunohistochemistry (IHC) assays showed that Derlin-1 was over-expressed in 114 SCCHN samples and five SCCHN cell lines. We found that the expression of Derlin-1 was positively associated with lymph node metastasis, clinical stage and recurrence in our SCCHN patients' samples. Survival analysis indicated that high expression of Derlin-1 was significantly associated with shorter overall survival (OS) and disease-free survival (DFS). Knock down expression of Derlin-1 in SCCHN cell lines was found to inhibit cell proliferation, metastasis and promote cell apoptosis. Further experiments showed that signals of PI3K/Akt, p53 and Smad2/3 may involve in these processes. In all, Derlin-1 might be a novel prognostic marker of SCCHN patients and plays an oncogenic role in SCCHN cell progression.

Keywords: SCCHN, Derlin-1, Survival, Apoptosis, Metastasis, EMT


Citation styles

APA
Pi, L., Zhu, G., She, L., Wei, M., Liu, G., Chen, C., Hu, D., Peng, F., Tan, H., Liu, Y., Huang, D., Tian, Y., Zhang, X. (2017). Elevated expression of Derlin-1 associates with unfavorable survival time of squamous cell carcinoma of the head and neck and promotes its malignance. Journal of Cancer, 8(12), 2336-2345. https://doi.org/10.7150/jca.19411.

ACS
Pi, L.; Zhu, G.; She, L.; Wei, M.; Liu, G.; Chen, C.; Hu, D.; Peng, F.; Tan, H.; Liu, Y.; Huang, D.; Tian, Y.; Zhang, X. Elevated expression of Derlin-1 associates with unfavorable survival time of squamous cell carcinoma of the head and neck and promotes its malignance. J. Cancer 2017, 8 (12), 2336-2345. DOI: 10.7150/jca.19411.

NLM
Pi L, Zhu G, She L, Wei M, Liu G, Chen C, Hu D, Peng F, Tan H, Liu Y, Huang D, Tian Y, Zhang X. Elevated expression of Derlin-1 associates with unfavorable survival time of squamous cell carcinoma of the head and neck and promotes its malignance. J Cancer 2017; 8(12):2336-2345. doi:10.7150/jca.19411. https://www.jcancer.org/v08p2336.htm

CSE
Pi L, Zhu G, She L, Wei M, Liu G, Chen C, Hu D, Peng F, Tan H, Liu Y, Huang D, Tian Y, Zhang X. 2017. Elevated expression of Derlin-1 associates with unfavorable survival time of squamous cell carcinoma of the head and neck and promotes its malignance. J Cancer. 8(12):2336-2345.

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