Fluid intake-to-bed time, nocturia frequency and the risk of urothelial carcinoma of the bladder: a case-control study

Cui, Jianfeng; Bo, Qiyu; Zhang, Ning; Chen, Shouzhen; Yu, Meng; Wang, Shiyu; Han, Jie; Chen, Pengxiang; Zhang, Dongqing; Zhu, Yaofeng; Shi, Benkang

doi:10.7150/jca.21555

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J Cancer 2017; 8(16):3268-3273. doi:10.7150/jca.21555 This issue Cite

Research Paper

Fluid intake-to-bed time, nocturia frequency and the risk of urothelial carcinoma of the bladder: a case-control study

Jianfeng Cui¹, Qiyu Bo², Ning Zhang¹, Shouzhen Chen¹, Meng Yu¹, Shiyu Wang¹, Jie Han³, Pengxiang Chen⁴, Dongqing Zhang¹, Yaofeng Zhu^1✉, Benkang Shi^1✉

1. Department of Urology, Qilu Hospital of Shandong University, Jinan, 250012 P.R. China;
2. Department of First Operating Room, Qilu Hospital of Shandong University, Jinan, 250012 P.R. China;
3. Department of Radiation Oncology, Shandong Cancer Hospital and Institute affiliated to Shandong University, Jinan, P.R. China;
4. Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, 250012 P.R. China.

Citation:

Cui J, Bo Q, Zhang N, Chen S, Yu M, Wang S, Han J, Chen P, Zhang D, Zhu Y, Shi B. Fluid intake-to-bed time, nocturia frequency and the risk of urothelial carcinoma of the bladder: a case-control study. J Cancer 2017; 8(16):3268-3273. doi:10.7150/jca.21555. https://www.jcancer.org/v08p3268.htm

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Abstract

Objectives: To clarify the potential role of fluid intake-to-bed time and nocturia frequency on bladder cancer risk in a hospital-based case-control study with Chinese people.

Materials and Methods: Four hundred and seven patients with histologically diagnosed bladder cancer and 400 matched controls were enrolled in this study. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression model.

Results: After adjustment for potential confounders, the fluid intake-to-bed time was associated with a decreased risk of BCa, with an OR of 0.586 (95% CI= 0.375-0.916, ≤1h) and 0.257 (95% CI= 0.162-0.407, >1h). The adjusted OR of BCa for subjects with more nocturia frequency (≥2 times) was 2.268 (95 % CI= 1.481-3474), compared to those with no nocturia.

Conclusion: We suggested strong protective effect of long fluid intake-to-bed time on BCa risk, especially in ones with ≥2 times nocturia frequency. These results provide evidence for identifying high-risk individuals and modifying their behaviors and lifestyle.

Keywords: bladder cancer, case-control study, fluid intake-to-bed time, nocturia

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APA

Cui, J., Bo, Q., Zhang, N., Chen, S., Yu, M., Wang, S., Han, J., Chen, P., Zhang, D., Zhu, Y., Shi, B. (2017). Fluid intake-to-bed time, nocturia frequency and the risk of urothelial carcinoma of the bladder: a case-control study. Journal of Cancer, 8(16), 3268-3273. https://doi.org/10.7150/jca.21555.

ACS

Cui, J.; Bo, Q.; Zhang, N.; Chen, S.; Yu, M.; Wang, S.; Han, J.; Chen, P.; Zhang, D.; Zhu, Y.; Shi, B. Fluid intake-to-bed time, nocturia frequency and the risk of urothelial carcinoma of the bladder: a case-control study. J. Cancer 2017, 8 (16), 3268-3273. DOI: 10.7150/jca.21555.

NLM

CSE

Cui J, Bo Q, Zhang N, Chen S, Yu M, Wang S, Han J, Chen P, Zhang D, Zhu Y, Shi B. 2017. Fluid intake-to-bed time, nocturia frequency and the risk of urothelial carcinoma of the bladder: a case-control study. J Cancer. 8(16):3268-3273.

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