J Cancer 2018; 9(14):2549-2558. doi:10.7150/jca.24560

Review

The emergence of long non-coding RNAs in hepatocellular carcinoma: an update

Li Peng 1,2*, Xiao-Qing Yuan3,4*, Chao-Yang Zhang1, Jiang-Yun Peng2, Ya-Qin Zhang1, Xi Pan5, Guan-Cheng Li1✉

1. Key Laboratory of Carcinogenesis of the Chinese Ministry of Health and the Key Laboratory of Carcinogenesis and Cancer Invasion of Chinese Ministry of Education, Xiangya Hospital, Central South University, Changsha 410078, P.R. China; Cancer Research Institute, Central South University, Changsha 410078, P.R. China.
2. Guangdong Province Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Research Center of Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, P.R. China.
3. Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China.
4. Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510120, China.
5. Department of Oncology, the third Xiangya Hospital, Central South University, Changsha 410013, P.R. China.
* Li Peng and Xiao-Qing Yuan are equally contributed to this work.

Abstract

Hepatocellular carcinoma (HCC) accounting for roughly 90% of all primary liver neoplasms is the sixth most frequent neoplasm and the second prominent reason of tumor fatality worldwide. As regulators of diverse biological processes, long non-coding RNAs (lncRNAs) are involved in onset and development of neoplasms. With the continuous booming of well-featured lncRNAs in HCC from 2016 to now, we reviewed the newly-presented comprehension about the relationship between lncRNAs and HCC in this study. To be specific, we summarized the overview function and study tools of lncRNAs, elaborated the roles of lncRNAs in HCC, and sketched the molecule mechanisms of lncRNAs in HCC. In addition, the application of lncRNAs serving as biomarkers in early diagnosis and outcome prediction of HCC patients was highlighted.

Keywords: long non-coding RNAs, hepatocellular carcinoma, function, mechanism, diagnosis, prognostic biomarker

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How to cite this article:
Peng L, Yuan XQ, Zhang CY, Peng JY, Zhang YQ, Pan X, Li GC. The emergence of long non-coding RNAs in hepatocellular carcinoma: an update. J Cancer 2018; 9(14):2549-2558. doi:10.7150/jca.24560. Available from http://www.jcancer.org/v09p2549.htm