Dioscin inhibits non-small cell lung cancer cells and activates apoptosis by downregulation of Survivin

Wang, Ruirui; Li, Xiaoying; Gan, Yu; Liao, Jinzhuang; Han, Shuangze; Li, Wei; Deng, Gaoyan

doi:10.7150/jca.89831

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International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

Nanotheranostics

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J Cancer 2024; 15(5):1366-1377. doi:10.7150/jca.89831 This issue Cite

Research Paper

Dioscin inhibits non-small cell lung cancer cells and activates apoptosis by downregulation of Survivin

Ruirui Wang^2#, Xiaoying Li^2#, Yu Gan², Jinzhuang Liao², Shuangze Han^2,3, Wei Li², Gaoyan Deng^1✉

1. Department of Thoracic Surgery, Hunan Chest Hospital, Changsha 410013, Hunan, China.
2. Department of Radiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
3. Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.
# Equal contribution.

Citation:

Wang R, Li X, Gan Y, Liao J, Han S, Li W, Deng G. Dioscin inhibits non-small cell lung cancer cells and activates apoptosis by downregulation of Survivin. J Cancer 2024; 15(5):1366-1377. doi:10.7150/jca.89831. https://www.jcancer.org/v15p1366.htm

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Abstract

Human malignancies exhibit elevated levels of survivin, and have been linked to poor prognosis. Targeting survivin expression is a promising therapeutic strategy against cancer cells. Natural compounds have become a hot topic in research due to their non-toxic, non-invasive, and efficient treatment of multiple diseases. In this current investigation, it was discovered that Dioscin, as a natural compound, exerted profound antitumor activity against NSCLC cell lines, inhibiting NSCLC cell viability and promoting apoptosis. Further mechanistic studies showed that Dioscin promoted ubiquitination-mediated survivin degradation via strengthening the interaction between survivin and the E3 ubiquitin ligase Fbxl7. Furthermore, Dioscin exhibited a strong tumor suppressive effect in xenograft tumor models, and Dioscin treatment led to a notable decrease in tumor volume and weight. Based on our findings, Dioscin is expected to be a potential antitumor agent for non-small cell lung cancer treatment.

Keywords: NSCLC, Survivin, Dioscin, Ubiquitination

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APA

Wang, R., Li, X., Gan, Y., Liao, J., Han, S., Li, W., Deng, G. (2024). Dioscin inhibits non-small cell lung cancer cells and activates apoptosis by downregulation of Survivin. Journal of Cancer, 15(5), 1366-1377. https://doi.org/10.7150/jca.89831.

ACS

Wang, R.; Li, X.; Gan, Y.; Liao, J.; Han, S.; Li, W.; Deng, G. Dioscin inhibits non-small cell lung cancer cells and activates apoptosis by downregulation of Survivin. J. Cancer 2024, 15 (5), 1366-1377. DOI: 10.7150/jca.89831.

NLM

CSE

Wang R, Li X, Gan Y, Liao J, Han S, Li W, Deng G. 2024. Dioscin inhibits non-small cell lung cancer cells and activates apoptosis by downregulation of Survivin. J Cancer. 15(5):1366-1377.

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