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Volume 7 (15); 2016

Research Paper

Massive parallel sequencing and digital gene expression analysis reveals potential mechanisms to overcome therapy resistance in pulmonary neuroendocrine tumors
Robert Fred Henry Walter, Claudia Vollbrecht, Daniel Christoph, Robert Werner, Jan Schmeller, Elena Flom, Georgia Trakada, Aggeliki Rapti, Vasilis Adamidis, Wolfgang Hohenforst-Schmidt, Jens Kollmeier, Thomas Mairinger, Jeremias Wohlschlaeger, Paul Zarogoulidis, Konstantinos Porpodis, Kurt Werner Schmidt, Fabian Dominik Mairinger
J. Cancer 2016; 7(15): 2165-2172. doi:10.7150/jca.16925
[Abstract] [Full text] [PDF] [PubMed] [PMC]

To Excavate Biomarkers Predictive of the Response for Capecitabine plus RAD001 through Nanostring-Based Multigene Assay in Advanced Gastric Cancer Patients
Hansang Lee, Jeeyun Lee, Insuk Sohn, Se Hoon Park, Joon Oh Park, Young Suk Park, Kyoung-Mee Kim, Won Ki Kang, Seung Tae Kim
J. Cancer 2016; 7(15): 2173-2178. doi:10.7150/jca.16551
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Association of common variants in MTAP with susceptibility and overall survival of osteosarcoma: a two-stage population-based study in Han Chinese
Liqiang Zhi, Dan Liu, Stephen G. Wu, Tianqing Li, Guanghui Zhao, Bo Zhao, Meng Li
J. Cancer 2016; 7(15): 2179-2186. doi:10.7150/jca.16609
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Downregulation of RNF128 Predicts Progression and Poor Prognosis in Patients with Urothelial Carcinoma of the Upper Tract and Urinary Bladder
Yi-Ying Lee, Chieh-Tien Wang, Steven Kuan-Hua Huang, Wen-Jeng Wu, Chun-Nung Huang, Ching-Chia Li, Ti-Chun Chan, Peir-In Liang, Chung-Hsi Hsing, Chien-Feng Li
J. Cancer 2016; 7(15): 2187-2196. doi:10.7150/jca.16798
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Alteration status and prognostic value of MET in head and neck squamous cell carcinoma
Yoon Ah Cho, Eun Kyung Kim, Su Jin Heo, Byoung Chul Cho, Hye Ryun Kim, Ji Myung Chung, Sun Och Yoon
J. Cancer 2016; 7(15): 2197-2206. doi:10.7150/jca.16686
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Clinicopathological features and relation between anaplastic lymphoma kinase (ALK) mutation and histological subtype of lung adenocarcinoma in Eastern European Caucasian population
Bojan Zaric, Vladimir Stojsic, Milana Panjkovic, Dragana Tegeltija, Vanesa Stepanov, Tomi Kovacevic, Tatjana Sarcev, Davorin Radosavljevic, Aleksandar Milovancev, Vasilis Adamidis, Paul Zarogoulidis, Wolfgang Hohenforst-Schmidt, Georgia Trakada, Aggeliki Rapti, Branislav Perin
J. Cancer 2016; 7(15): 2207-2212. doi:10.7150/jca.16768
[Abstract] [Full text] [PDF] [PubMed] [PMC]

High Expression of 17β-hydroxysteroid Dehydrogenase Type 2 is Associated with a Better Prognosis in Urothelial Carcinoma of the Urinary Tract
Chieh-Tien Wang, Chien-Feng Li, Wen-Jeng Wu, Chun-Nung Huang, Ching-Chia Li, Wei-Ming Li, Ti-Chun Chan, Peir-In Liang, Chung-Hsi Hsing, Kuang-Ming Liao
J. Cancer 2016; 7(15): 2221-2230. doi:10.7150/jca.16777
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Interferon-Tau has Antiproliferative effects, Represses the Expression of E6 and E7 Oncogenes, Induces Apoptosis in Cell Lines Transformed with HPV16 and Inhibits Tumor Growth In Vivo
Herbey Oswaldo Padilla-Quirarte, Cesar Trejo-Moreno, Geny Fierros-Zarate, Jhoseline Carnalla Castañeda, Marie Palma-Irizarry, Eva Hernández-Márquez, Ana Isabel Burguete-Garcia, Oscar Peralta-Zaragoza, Vicente Madrid-Marina, Kirvis Torres-Poveda, Victor Hugo Bermúdez-Morales
J. Cancer 2016; 7(15): 2231-2240. doi:10.7150/jca.15502
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Incidence and Impact of Lymph Node Metastases in Advanced Ovarian Cancer: Implications for Surgical Treatment
Cornelia Bachmann, Robert Bachmann, Falko Fend, Diethelm Wallwiener
J. Cancer 2016; 7(15): 2241-2246. doi:10.7150/jca.15644
[Abstract] [Full text] [PDF] [PubMed] [PMC]

The Effects of Anti-inflammatory Drug Treatment in Gastric Cancer Prevention: an Update of a Meta-analysis
Pengfei Kong, Ruiyan Wu, Xuechao Liu, Jianjun Liu, Shangxiang Chen, Minting Ye, Chenlu Yang, Ze Song, Wenzhuo He, Chenxi Yin, Qiong Yang, Chang Jiang, Fangxin Liao, Roujun Peng, Zhiwei Zhou, Dazhi Xu, Liangping Xia
J. Cancer 2016; 7(15): 2247-2257. doi:10.7150/jca.16524
[Abstract] [Full text] [PDF] [PubMed] [PMC]

New panel of microsatellite alterations detectable in the EBC for lung cancer prognosis
Giovanna E Carpagnano, Donato Lacedonia, Elisabetta Crisetti, Domenico Martinelli, Maria P Foschino-Barbaro
J. Cancer 2016; 7(15): 2266-2269. doi:10.7150/jca.15921
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Nucleophosmin Mutations Induce Chemosensitivity in THP-1 Leukemia Cells by Suppressing NF-κB Activity and Regulating Bax/Bcl-2 Expression
Shuaishuai Zhang, Fengxian Qin, Liyuan Yang, Jingrong Xian, Qin Zou, Hongjun Jin, Lu Wang, Ling Zhang
J. Cancer 2016; 7(15): 2270-2279. doi:10.7150/jca.16010
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Aberrant methylation of CDH13 can be a diagnostic biomarker for lung adenocarcinoma
Weilin Pu, Xin Geng, Sidi Chen, Lixing Tan, Yulong Tan, An Wang, Zhouyi Lu, Shicheng Guo, Xiaofeng Chen, Jiucun Wang
J. Cancer 2016; 7(15): 2280-2289. doi:10.7150/jca.15758
[Abstract] [Full text] [PDF] [PubMed] [PMC]

A Retrospective Review of Chemotherapy for Patients with Small Bowel Adenocarcinoma in British Columbia
Donat Duerr, Susan Ellard, Yongliang Zhai, Marianne Taylor, Sanjay Rao
J. Cancer 2016; 7(15): 2290-2295. doi:10.7150/jca.16606
[Abstract] [Full text] [PDF] [PubMed] [PMC]

The learning curves of robotic and three-dimensional laparoscopic surgery in cervical cancer
Xue-Lian Li, Dan-Feng Du, Hua Jiang
J. Cancer 2016; 7(15): 2304-2308. doi:10.7150/jca.16653
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Pre-treatment serum alkaline phosphatase and lactate dehydrogenase as prognostic factors in triple negative breast cancer
Bo Chen, Danian Dai, Hailin Tang, Xi Chen, Xiaohong Ai, Xiaojia Huang, Weidong Wei, Xiaoming Xie
J. Cancer 2016; 7(15): 2309-2316. doi:10.7150/jca.16622
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Rab14 Suppression Mediated by MiR-320a Inhibits Cell Proliferation, Migration and Invasion in Breast Cancer
Juan Yu, Lei Wang, Haiping Yang, Di Ding, Lei Zhang, Jigang Wang, Qi Chen, Qiang Zou, Yiting Jin, Xiuping Liu
J. Cancer 2016; 7(15): 2317-2326. doi:10.7150/jca.15737
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Reduction of CA125 Levels During Neoadjuvant Chemotherapy Can Predict Cytoreduction to No Visible Residual Disease in Patients with Advanced Epithelial Ovarian Cancer, Primary Carcinoma of Fallopian tube and Peritoneal Carcinoma
Jing Zeng, Jie Yin, Xiao Song, Ying Jin, Yan Li, Lingya Pan
J. Cancer 2016; 7(15): 2327-2332. doi:10.7150/jca.16761
[Abstract] [Full text] [PDF] [PubMed] [PMC]

An In Vitro Inverted Vertical Invasion Assay to Avoid Manipulation of Rare or Sensitive Cell Types
Tanner J. McArdle, Brenda M. Ogle, Felicite K. Noubissi
J. Cancer 2016; 7(15): 2333-2340. doi:10.7150/jca.15812
[Abstract] [Full text] [PDF] [PubMed] [PMC]

C-Reactive Protein/Albumin Ratio (CAR) as a Prognostic Factor in Patients with Non-Metastatic Nasopharyngeal Carcinoma
ShaSha He, Yan Wang, HaiYang Chen, Lin Yang, ShaoBo Liang, LiXia Lu, Yong Chen
J. Cancer 2016; 7(15): 2360-2366. doi:10.7150/jca.16443
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Positive Prehabilitative Effect of Intense Treadmill Exercise for Ameliorating Cancer Cachexia Symptoms in a Mouse Model
Hyunseok Jee, Ji-Eun Chang, Eun Joo Yang
J. Cancer 2016; 7(15): 2378-2387. doi:10.7150/jca.17162
[Abstract] [Full text] [PDF] [PubMed] [PMC]

The Role of BCA2 in the Endocytic Trafficking of EGFR and Significance as a Prognostic Biomarker in Cancer
Jennifer M. Wymant, Stephen Hiscox, Andrew D. Westwell, Sylvie Urbé, Michael J. Clague, Arwyn T. Jones
J. Cancer 2016; 7(15): 2388-2407. doi:10.7150/jca.15055
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells
Szu-Yuan Wu, Ming-De Yan, Alexander T.H. Wu, Kevin Sheng-Po Yuan, Shing Hwa Liu
J. Cancer 2016; 7(15): 2408-2419. doi:10.7150/jca.15703
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Association between the KRAS Gene Polymorphisms and Papillary Thyroid Carcinoma in a Chinese Han Population
Lifeng Ning, Wenwang Rao, Yaqin Yu, Xiaoli Liu, Yuchen Pan, Yuan Ma, Rui Liu, Shangchao Zhang, Hui Sun, Qiong Yu
J. Cancer 2016; 7(15): 2420-2426. doi:10.7150/jca.16507
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Short Research Communication

Antimicrobial peptide LL-37 participates in the transcriptional regulation of melanoma cells
Mindy Muñoz, Madeleine Craske, Patricia Severino, Thais Martins de Lima, Paul Labhart, Roger Chammas, Irineu Tadeu Velasco, Marcel Cerqueira César Machado, Brian Egan, Helder I Nakaya, Fabiano Pinheiro da Silva
J. Cancer 2016; 7(15): 2341-2345. doi:10.7150/jca.16947
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review

Multidimensional Roles of Collagen Triple Helix Repeat Containing 1 (CTHRC1) in Malignant Cancers
Neng Jiang, YongMei Cui, JunXiu Liu, XiaoLin Zhu, Hui Wu, Zheng Yang, ZunFu Ke
J. Cancer 2016; 7(15): 2213-2220. doi:10.7150/jca.16539
[Abstract] [Full text] [PDF] [PubMed] [PMC]

TFIIH: New Discoveries Regarding its Mechanisms and Impact on Cancer Treatment
Mario Zurita, Grisel Cruz-Becerra
J. Cancer 2016; 7(15): 2258-2265. doi:10.7150/jca.16966
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Advances and Challenges on Cancer Cells Reprogramming Using Induced Pluripotent Stem Cells Technologies
Diana Aparecida Dias Câmara, Lisley Inata Mambelli, Allan Saj Porcacchia, Irina Kerkis
J. Cancer 2016; 7(15): 2296-2303. doi:10.7150/jca.16629
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Obesity and cancer: the role of adipose tissue and adipo-cytokines-induced chronic inflammation
Rosa Divella, Raffaele De Luca, Ines Abbate, Emanuele Naglieri, Antonella Daniele
J. Cancer 2016; 7(15): 2346-2359. doi:10.7150/jca.16884
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Pre-clinical evaluation of a novel class of anti-cancer agents, the Pyrrolo-1, 5-benzoxazepines.
LM Greene, S Butini, G Campiani, DC Williams, DM Zisterer
J. Cancer 2016; 7(15): 2367-2377. doi:10.7150/jca.16616
[Abstract] [Full text] [PDF] [PubMed] [PMC]