Prognostic Value of the Albumin-to-γ-glutamyltransferase Ratio for Gallbladder Cancer Patients and Establishing a Nomogram for Overall Survival

Sun, Lejia; Ke, Xindi; Wang, Dongyue; Yin, Huanhuan; Jin, Bao; Xu, Haifeng; Du, Shunda; Xu, Yiyao; Zhao, Haitao; Lu, Xin; Sang, Xinting; Zhong, Shouxian; Yang, Huayu; Mao, Yilei

doi:10.7150/jca.49242

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J Cancer 2021; 12(14):4172-4182. doi:10.7150/jca.49242 This issue Cite

Research Paper

Prognostic Value of the Albumin-to-γ-glutamyltransferase Ratio for Gallbladder Cancer Patients and Establishing a Nomogram for Overall Survival

Lejia Sun^1*, Xindi Ke^2*, Dongyue Wang^2*, Huanhuan Yin², Bao Jin¹, Haifeng Xu¹, Shunda Du¹, Yiyao Xu¹, Haitao Zhao¹, Xin Lu¹, Xinting Sang¹, Shouxian Zhong¹, Huayu Yang^1✉, Yilei Mao^1✉

1. Department of Liver Surgery, Peking Union Medical College (PUMC) Hospital, PUMC & Chinese Academy of Medical Sciences, Beijing, 100730, China.
2. Peking Union Medical College (PUMC), PUMC & Chinese Academy of Medical Sciences, Beijing, 100730, China.
* These authors contributed equally to this article.

Citation:

Sun L, Ke X, Wang D, Yin H, Jin B, Xu H, Du S, Xu Y, Zhao H, Lu X, Sang X, Zhong S, Yang H, Mao Y. Prognostic Value of the Albumin-to-γ-glutamyltransferase Ratio for Gallbladder Cancer Patients and Establishing a Nomogram for Overall Survival. J Cancer 2021; 12(14):4172-4182. doi:10.7150/jca.49242. https://www.jcancer.org/v12p4172.htm

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Abstract

Purpose: The albumin-to-γ-glutamyltransferase ratio (AGR), a novel inflammation-related index, has been reported to have prognostic importance in several malignancies but not yet in gallbladder cancer (GBC). This study intended to assess the prognostic value of AGR in GBC and to develop a nomogram based on AGR for predicting overall survival (OS) in GBC patients after surgery.

Methods: Medical records of 140 qualified GBC patients between July 2003 and June 2017 were retrospectively analyzed. The function “surv_cutpoint” in the R package “survminer” was implemented to discover the optimal cut-off value of AGR. A nomogram on the fundamental of Cox model was established in the training cohort and was internally validated using calibration curves, Harrell's concordance index, time-dependent AUC plots and decisive curve analyses.

Results: The optimal AGR cut-off value concerning overall survival was 2.050. Univariate and multivariate analyses demonstrated that AGR (HR=0.354, P=0.004), T stage (HR=3.114, P=0.004), R0 resection (HR=0.448, P=0.003), BMI (HR=0.470, P=0.002) and CA19-9 (HR=1.704, P=0.048) were independent predictors for OS. The nomogram combining these prognostic factors showed considerable prognostic performance in term of consistency, discrimination and net benefit.

Conclusion: AGR has independent prognostic value for OS in GBC patients receiving surgery. A nomogram incorporating AGR, T stage, R0 resection, CA19-9 and BMI achieved enhanced prognostic ability.

Keywords: albumin-to-γ-glutamyltransferase ratio, gallbladder cancer, prognostic value, nomogram.

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APA

Sun, L., Ke, X., Wang, D., Yin, H., Jin, B., Xu, H., Du, S., Xu, Y., Zhao, H., Lu, X., Sang, X., Zhong, S., Yang, H., Mao, Y. (2021). Prognostic Value of the Albumin-to-γ-glutamyltransferase Ratio for Gallbladder Cancer Patients and Establishing a Nomogram for Overall Survival. Journal of Cancer, 12(14), 4172-4182. https://doi.org/10.7150/jca.49242.

ACS

Sun, L.; Ke, X.; Wang, D.; Yin, H.; Jin, B.; Xu, H.; Du, S.; Xu, Y.; Zhao, H.; Lu, X.; Sang, X.; Zhong, S.; Yang, H.; Mao, Y. Prognostic Value of the Albumin-to-γ-glutamyltransferase Ratio for Gallbladder Cancer Patients and Establishing a Nomogram for Overall Survival. J. Cancer 2021, 12 (14), 4172-4182. DOI: 10.7150/jca.49242.

NLM

CSE

Sun L, Ke X, Wang D, Yin H, Jin B, Xu H, Du S, Xu Y, Zhao H, Lu X, Sang X, Zhong S, Yang H, Mao Y. 2021. Prognostic Value of the Albumin-to-γ-glutamyltransferase Ratio for Gallbladder Cancer Patients and Establishing a Nomogram for Overall Survival. J Cancer. 12(14):4172-4182.

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