Journal of Cancer

open access Global reach, higher impact

Research Paper Development and Validation of an m6A-Derived Prognostic Signature in Lung Adenocarcinoma Zheng Shao, YongLi Situ, Bairu Lai, Ying Xu, Jv Chen, Li Deng, QinYing Xu, Meng Liang, Zhu Liang, ZhanQiang Xie J. Cancer 2026; 17(6): 1134-1154. doi:10.7150/jca.134792 Full text PDF

Research Paper Epidemiological Trends and Shared Molecular Signatures of Pancreatic Ductal Adenocarcinoma and Diabetes: An Integrative Analysis Based on Global Burden of Disease and Gene Expression Omnibus Datasets Jiaxi Zhang, Zhibin Liu, Ke Huang, Junkoo Yi, Myoung Ok Kim J. Cancer 2026; 17(6): 1125-1133. doi:10.7150/jca.134528 Full text PDF

Research Paper CellVizio^® System for Mesothorax Lymphadenopathy Rapid on Site, 18G needle: Pros and Cons Paul Zarogoulidis, Wolfgang Hofenforst-Schwidt, Haidong Huang, Stavros Tryfon, Yifei Zhang, Xiaping Shen, Guoren Ma, Kyriakos Amarantidis, Elena Maragouli, Vasilis Papadopoulos, Eleni-Isidora Perdikouri, Vagelis Voulgaris, Lutz Freitag, Chrysoula Margioula-Siarkou, Theodora Tsiouda, Paschalis Ntolios, Stamatis Petousis, Konstantina Triantafylopoulou, Kosmas Tsakiridis, Nikolaos Courcoutsakis, Sofia Baka, Dimitris Baloukas, Paschalis Steiropoulos, Bojan Zaric, Xiaping Shen J. Cancer 2026; 17(6): 1117-1124. doi:10.7150/jca.136122 Full text PDF

Review miR-150-5p at the Interface of Cancer Biology and Immune Regulation: Dual Roles, Mechanisms, and Therapeutic Opportunities Iris Lin, Pardis Shirkani, Cathie Garnis J. Cancer 2026; 17(6): 1105-1116. doi:10.7150/jca.119966 Full text PDF

Research Paper Vemurafenib Induces Apoptosis via JNK Activation and AKT Inhibition in Hepatocellular Carcinoma Yu Rim Cho, Ke Huang, Zhibin Liu, Hyeonjin Kim, Chae Yeon Kim, Lei Ma, Nangwon Yee, Chae Rim Kim, Geun Hye Park, Jiaxi Zhang, Zae Young Ryoo, Sung Hyun Kim, Myoung Ok Kim J. Cancer 2026; 17(5): 1094-1104. doi:10.7150/jca.130097 Full text PDF PubMed PMC

Research Paper Serum Thyroid Biomarkers for Diagnosing Malignant Thyroid Nodules: A Machine Learning Approach with External and Causal Validation Qingling Gu, Faling Xue, Xiaojing Shi, Zhuoling Zheng, Wenqing Wang, Zhuolin Yang, Yiyu Zhang, Wenqi Huang, Min Huang, Zhongxing Wang, Jiali Li J. Cancer 2026; 17(5): 1082-1093. doi:10.7150/jca.131422 Full text PDF PubMed PMC

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Issue 5; 2026

Indexed in PubMed and SCI expanded; full texts in Europe PMC. ...

Development and Validation of an m6A-Derived Prognostic Signature in Lung Adenocarcinoma

Background: Lung adenocarcinoma (LUAD) exhibits extensive molecular heterogeneity and poor prognosis, necessitating novel epigenetic biomarkers. N6-methyladenosine (m6A) modification, a a pivotal epigenetic regulator of RNA, is frequently dysregulated in LUAD, yet its systematic roles in clinical prognosis and the tumor microenvironment (TME) remain poorly elucidated. Methods: Transcriptomic profiles and clinical data from large-scale cohorts were ...

Serum Thyroid Biomarkers for Diagnosing Malignant Thyroid Nodules: A Machine Learning Approach with External and Causal Validation

Background: Thyroid nodules (TNs) are common, and accurate malignancy risk stratification is critical for clinical decision-making. Although serum thyroid biomarkers are routinely measured, their contribution to malignancy discrimination remains insufficiently characterized. Thus, we aimed to develop a practical and biologically grounded model for identifying malignant TNs using routinely clinical data. Methods: We retrospectively analyzed 5537 patients ...