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Review Development of nasopharyngeal carcinoma target delineation: from two-dimensional radiotherapy to adaptive precision radiotherapy Full text PDF
Research Paper Dehydroleucodine Induces ROS-Mediated Mitochondrial Apoptosis and G2/M Cell Cycle Arrest in Oral Squamous Cell Carcinoma Full text PDF
Review The Emerging Role of CACNA1E in Cancer: Molecular Mechanisms and Therapeutic Implications Full text PDF
Research Paper Development and Validation of an m6A-Derived Prognostic Signature in Lung Adenocarcinoma Full text PDF
Research Paper Epidemiological Trends and Shared Molecular Signatures of Pancreatic Ductal Adenocarcinoma and Diabetes: An Integrative Analysis Based on Global Burden of Disease and Gene Expression Omnibus Datasets Full text PDF
Research Paper CellVizio® System for Mesothorax Lymphadenopathy Rapid on Site, 18G needle: Pros and Cons Full text PDF
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The Emerging Role of CACNA1E in Cancer: Molecular Mechanisms and Therapeutic Implications
Voltage-gated calcium channels (VGCCs) are crucial membrane proteins that mediate calcium influx. The CACNA gene family, which encodes the alpha subunits of VGCC complexes, is essential for forming functional calcium channels and plays significant roles in various cancers. This review focuses on the CACNA1E gene, which encodes the Cav2.3 channel α1E subunit, and systematically elaborates its role in cancer. Studies have identified CACNA1E as ...
Oral squamous cell carcinoma (OSCC) is a highly aggressive malignancy with poor clinical outcomes due largely to recurrence and therapy resistance. Dehydroleucodine (DhL) is a sesquiterpene lactone derived from Asteraceae species, which has demonstrated anticancer activity in several tumor models. However, its therapeutic relevance in OSCC has not been established. This study investigated the antitumor effects of DhL and the mechanisms underlying ...