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Research Paper Longitudinal CT-based deep learning radiomics for predicting prognosis in esophageal squamous cell carcinoma treated with definitive chemoradiotherapy: a two-center study Xinyang Hu, Wubulaishan Maitudi, Xi Chen, Lina Zhao, Qingsong Pang J. Cancer 2026; 17(4): 808-818. doi:10.7150/jca.126804 Full text PDF


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Research Paper Therapeutic Targeting of Oxidative Phosphorylation in Microsatellite Instability-High Gastric Cancer Bing Ang, Yi Bai, Xiyue Deng, Qiong Wu, Yuqian Wang, Shanshan Xu, Weixin Zhang, Yang Li, Dapeng Chen, Ruixi Li, Siyang Li, Zhigang Zhao, Yamin Zhang J. Cancer 2026; 17(4): 797-807. doi:10.7150/jca.127225 Full text PDF


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Research Paper WISP-3 promotes angiogenesis in non-small cell lung cancer through p38/JNK-c-Jun-mediated PDGF-A upregulation En-Ming Chang, Syuan-Ling Lin, Ching-Yuan Cheng, Chih-Hsin Tang, Yu-Chen Chen, Chiang-Wen Lee, Chih-Yang Lin J. Cancer 2026; 17(4): 787-796. doi:10.7150/jca.127681 Full text PDF


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Research Paper High PMS2 Expression-Based Nomogram for Risk Stratification in Resected Hepatocellular Carcinoma: Application to Recurrence and Neoadjuvant Therapy Selection Wenchen Gong, Ruyu Han, Liyu Sun, Yingrui Gao, Zhiqiang Han, Yimeng Wang, Yuren Xia, Yukun Wei, Tianqiang Song, Lu Chen, Xiangdong Tian J. Cancer 2026; 17(4): 771-786. doi:10.7150/jca.131997 Full text PDF


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Review Roles of Cellular Neighborhoods in Lung Cancer Rui Bai, Wenjie Sun J. Cancer 2026; 17(4): 759-770. doi:10.7150/jca.132848 Full text PDF


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Research Paper An integrated bulk and single-cell transcriptomic analysis reveals stemness-driven immune regulation and therapeutic vulnerability in colorectal cancer I-Hung Chen, Kai-Fu Chang, Chien-Cheng Chao, Chung-Hsien Lin, Chih-Hsuan Chang, Ching-Chung Ko, Hui-Ru Lin, Chi-Jen Wu, Chien-Han Yuan, Sachin Kumar, Dahlak Daniel Solomon, Do Thi Minh Xuan, Neethu Palekkode, Ayman Fathima, Yung-Kuo Lee, Chung-Bao Hsieh, Yuen-Jung Wu J. Cancer 2026; 17(4): 740-758. doi:10.7150/jca.132694 Full text PDF

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Issue 3; 2026

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Indexed in PubMed and SCI expanded; full texts in Europe PMC. ...


An integrated bulk and single-cell transcriptomic analysis reveals stemness-driven immune regulation and therapeutic vulnerability in colorectal cancer

Tumor stemness is increasingly recognized as a key contributor to tumor heterogeneity, immune regulation, and therapeutic resistance in colorectal cancer (CRC). In this study, we developed a stemness-based risk model using bulk transcriptomic data from The Cancer Genome Atlas and evaluated its prognostic and therapeutic relevance through integrative analyses. The proposed risk score robustly stratified patients into distinct prognostic groups and ...


Roles of Cellular Neighborhoods in Lung Cancer

The occurrence and development of lung cancer (LC) involve complex interactions between various cell types in the tumor microenvironment (TME). Understanding the spatial distribution and interaction mechanisms of these cells may be the key to overcoming LC. The advancements of single-cell and spatial transcriptome techniques have promoted our understanding of cellular neighborhoods (CNs) and their functions in the pathogenesis of LC. In this review, ...

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