Impact Factor ISSN: 1837-9664
Review Advances in CAR-T Cell Therapy: From Structural Design Innovations to Clinical Translation Challenges Full text PDF
Review Regulatory roles of E3 ubiquitin ligase RNF128 in inflammatory diseases and tumors Full text PDF
Research Paper Integrated Pan-Cancer, Single-Cell, and Spatial Transcriptomic Analyses Identify ZDHHC12 as a Biomarker Associated with Macrophage Infiltration and the Immune Landscape in Glioma Full text PDF
Review Liquid Biopsy and Nonendoscopic Biomarkers for Precision Early Detection of Esophageal Cancer: Evidence, Risk Stratification and Translational Challenges Full text PDF
Research Paper Smoking-Associated Enrichment of CXCL13+ Tfh Cells and VCAM1+ Fibroblasts Is Linked to Tertiary Lymphoid Structure Formation in Lung Adenocarcinoma Full text PDF
Research Paper Chronically Established ρ0 Cancer Cells Exhibit Shared Stemness-Associated and Aggressive Phenotypes Across Multiple Cancer Cell Lines Full text PDF
Issue 9; 2026
Indexed in PubMed and SCI expanded; full texts in Europe PMC. ...
Chimeric Antigen Receptor T cells (CAR-T) therapy represents a groundbreaking technology in the field of tumor immunotherapy. This innovative approach involves the genetic engineering of T cells to specifically identify and eradicate tumor cells, and it has been shown to yield remarkable efficacy in treating hematological malignancies. This article provides a comprehensive overview of the core advancements in CAR-T technology, emphasizing the evolution ...
Chronically established mitochondrial DNA-depleted (ρ0) cancer cells may exhibit phenotypic changes beyond metabolic dysfunction; however, whether such changes are shared across different cancer types remains unclear. In this study, we generated chronically established ρ0 models from pancreatic, lung, and breast cancer cell lines and examined their common phenotypic features. Compared with their parental wild-type counterparts, the ρ0 ...