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Research Paper Hadhb Deficiency Inhibits Lung Tumorigenesis Via Activating ER Stress Full text PDF
Research Paper Phenotypic risk factors linked to acute radiation-induced toxicities: a phenome-wide Mendelian randomization study of 12,042 cancer patients Full text PDF
Research Paper Exploratory Serum Metabolomics Identifies Metabolic Subgroups Across the Gastric Dysplasia-Early Cancer Spectrum Full text PDF
Review The Role of Traditional Chinese Medicine in Metabolic Reprogramming, Tumor microenvironment, and Macrophage Regulation: Mechanisms and Advances in Preclinical Studies Full text PDF
Research Paper Determination of protein markers of inflammasome formation and ferroptosis in thyroid cancer based on gender Full text PDF
Review Anticancer Effects of Cepharanthine: an Updated Minireview Full text PDF
Indexed in PubMed and SCI expanded; full texts in Europe PMC. ...
Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid cancer, with a globally increasing incidence. The disease exhibits significant sex-related clinical and biological differences: while incidence is approximately three times higher in women, men face a greater risk of lymph node metastasis, recurrence, and mortality. This gender disparity may be associated with hormonal factors, particularly estrogens, which are known to modulate ...
Hadhb Deficiency Inhibits Lung Tumorigenesis Via Activating ER Stress
Lung cancer remains the leading cause of cancer-related mortality worldwide, yet its molecular pathogenesis is not fully understood. Here, we identify HADHB, encoding a mitochondrial β-ketothiolase as a novel oncogene in lung cancer. Using a HadhbPB/PB mouse model, we demonstrate that Hadhb deficiency in mice significantly suppresses K-RasG12D-driven lung tumor progression by impairing cancer cell proliferation and enhancing apoptosis. Mechanistically, ...