Journal of Cancer

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Research Paper Hadhb Deficiency Inhibits Lung Tumorigenesis Via Activating ER Stress Wuhou Dai, Dong Xu, Yubin Lei, Shujing Zhang, Tonglu Yu, Wufan Tao, Xiaofeng Chen, Xingrong Du J. Cancer 2026; 17(5): 990-1001. doi:10.7150/jca.130384 Full text PDF

Research Paper Phenotypic risk factors linked to acute radiation-induced toxicities: a phenome-wide Mendelian randomization study of 12,042 cancer patients Wenyi Jiang, Bo Li, Siyuan Zhang, Xin Sui, Yueting Liang, Minqi Jia, Shaoran Jiang, Lijuan Li, Huajing Teng, Weihu Wang J. Cancer 2026; 17(5): 979-989. doi:10.7150/jca.127072 Full text PDF

Research Paper Exploratory Serum Metabolomics Identifies Metabolic Subgroups Across the Gastric Dysplasia-Early Cancer Spectrum Sihyun Chae, Hee Sang You, Jae Gyu Kim, Joo-Youn Cho J. Cancer 2026; 17(5): 968-978. doi:10.7150/jca.131608 Full text PDF

Review The Role of Traditional Chinese Medicine in Metabolic Reprogramming, Tumor microenvironment, and Macrophage Regulation: Mechanisms and Advances in Preclinical Studies AnAn Yu, Donglai Yang, Hongyu Chen J. Cancer 2026; 17(5): 952-967. doi:10.7150/jca.126434 Full text PDF

Research Paper Determination of protein markers of inflammasome formation and ferroptosis in thyroid cancer based on gender Raúl Díaz-Pedrero, Oscar Fraile-Martinez, Cielo García-Montero, Diego Liviu Boaru, Patricia De Castro-Martinez, Diego De Leon-Oliva, Laura López-Gonzalez, Beatriz García-González, Isabel Pérez-González, Majd N. Michael Alhaddadin, Silvestra Barrena-Blázquez, Connie Ferrara-Coppola, Ana María Villar-Carrillo, Laura Gutierrez-Gonzalez, Miguel Pascual-Casero, Félix Mañez, Tomás Ratia Giménez, Inmaculada Lasa-Unzúe, Manuel Díez Alonso, Alberto Gutiérrez-Calvo, Luis G Guijarro, Melchor Álvarez-Mon, Montserrat Chao Crecente, Miguel A Saez, Miguel A Ortega J. Cancer 2026; 17(5): 937-951. doi:10.7150/jca.128886 Full text PDF

Review Anticancer Effects of Cepharanthine: an Updated Minireview Pei-Yin Yang, Jyun-Xue Wu, Ya-Hui Chen, Shun-Fa Yang, Yi-Tzu Chu, Yi-Hsuan Hsiao J. Cancer 2026; 17(5): 925-936. doi:10.7150/jca.118647 Full text PDF

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Phenotypic risk factors linked to acute radiation-induced toxicities: a phenome-wide Mendelian randomization study of 12,042 cancer patients

Objective: This study aims to systematically evaluate phenome-wide clinical factors contributing to radiation-induced toxicities (RITs) and provide evidence to identify acute RITs-associated risk factors for personalized radiation treatment stratification. Methods: Leveraging genome-wide association study data from 12,042 patients with prostate, head and neck, breast, or lung cancer, we conducted MR-PheWAS (phenome-wide association study integrated ...

The Role of Traditional Chinese Medicine in Metabolic Reprogramming, Tumor microenvironment, and Macrophage Regulation: Mechanisms and Advances in Preclinical Studies

Background: Cancer metabolism reprogramming is a hallmark of tumorigenesis, playing a critical role in tumor progression and therapeutic resistance. Macrophages in the Tumor microenvironment (TME) play a crucial role in tumor progression and immune system evasion. Traditional Chinese Medicine (TCM) has shown potential in influencing cancer metabolism and immune functions, offering new therapeutic possibilities. Objective: This review explores the ...