Journal of Cancer

Research Paper Integrative Locus-Resolved Genomics Uncovers Distinct Genetic Links Between Leukocyte Telomere Length and Colon Cancer Susceptibility Aocheng Ji, Wenbin Xu, Yonghui Wu, Yiyi Jin, Wen Lin, Longxin Xiong, Chunyan Zeng J. Cancer 2026; 17(11): 1952-1964. doi:10.7150/jca.142445 Full text PDF

Research Paper [¹⁷⁷Lu]Lu-PSMA-617-Mediated Endoradiotherapy of Breast Cancer by Targeting Tumor-Associated Neovasculature Xiuwei Wu, Xiaohong Li, Lili Chen, Rou Li, Xiao Li, Qinqin Yang, Maohua Rao, Yangchun Chen J. Cancer 2026; 17(11): 1940-1951. doi:10.7150/jca.138719 Full text PDF

Review Delayed First Childbirth Reshapes Postpartum Breast Cancer Risk: A Biphasic Model Caihui Zhu, Wei Zhu, Zhilong Ai J. Cancer 2026; 17(11): 1927-1939. doi:10.7150/jca.141884 Full text PDF

Research Paper Real-World Comparative Survival Outcomes of First-Line Serplulimab Plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer: A Single-Center Retrospective Cohort Study Yuhao Jing, Miao Li, Songxiang Li, Yifan Zhao, Zhenbao Zhou, Xin Li, Meng Wang J. Cancer 2026; 17(11): 1915-1926. doi:10.7150/jca.140183 Full text PDF PubMed PMC

Research Paper An Eight-Gene Metabolic Prognostic Signature in Head and Neck Squamous Cell Carcinoma: Cross-Cohort Evaluation, Single-Cell Analysis, and Preliminary Functional Evaluation of PYGL and G6PD Wanyi Kou, Ruixin Guo, Yifan Zhang, Chensi Xu, Wenqi Sha, Yijie Chen, Yuran Lei, Ningrui Zhang, Kun Liao, Danni Liang, Yang Zhang, Zhenxing Wei, Zhenghui Wang J. Cancer 2026; 17(11): 1895-1914. doi:10.7150/jca.134402 Full text PDF PubMed PMC

Research Paper FLNA Expression in Cancer-Associated Fibroblasts Is Associated with Immunosuppression and Tumor Progression in Colorectal Cancer Qianze Yao, Ningbo Liu, Shilong Li, Bang Liu, Guozheng Ding, Hengbin Zhao, Weihua Fu J. Cancer 2026; 17(11): 1879-1894. doi:10.7150/jca.134223 Full text PDF PubMed PMC

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Issue 10; 2026

Indexed in PubMed and SCI expanded; full texts in Europe PMC. ...

Real-World Comparative Survival Outcomes of First-Line Serplulimab Plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer: A Single-Center Retrospective Cohort Study

Background: Extensive-stage small-cell lung cancer (ES-SCLC) remains an aggressive malignancy with poor survival despite platinum-etoposide chemotherapy. Although serplulimab plus chemotherapy has demonstrated a survival benefit in randomized trials, comparative real-world evidence remains limited. We therefore evaluated survival outcomes with first-line serplulimab plus chemotherapy versus chemotherapy alone in patients with ES-SCLC. Methods: We ...

FLNA Expression in Cancer-Associated Fibroblasts Is Associated with Immunosuppression and Tumor Progression in Colorectal Cancer

Background: The role of Filamin A (FLNA) in colorectal cancer (CRC), particularly within the stromal compartment, remains poorly defined. This study investigates its expression, function, and clinical relevance in CRC. Methods: We integrated transcriptomic data from the GSE39582 training cohort and TCGA/GSE75316 validation cohorts. Analyses included functional enrichment, tumor microenvironment (TME) assessment (ESTIMATE, TIDE), immune correlation, ...