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Research Paper GPCRs interaction with LGR5: Implications to cancer stemness Full text PDF
Research Paper Arteannuin B Induces Ferroptosis in Colorectal Cancer Cells via GDF15/HMGCS1/GPX4 Axis Full text PDF
Review tsRNA's Biological Function and its Potential Application in Disease Diagnosis and Prognosis Full text PDF
Research Paper Long-Term Empagliflozin Treatment (50 Days) Attenuates Protease Activity, Migration, and Stemness-Associated Phenotypes in BFTC-909 Renal Pelvis Transitional Cell Carcinoma Cells Full text PDF
Research Paper A digital polymerase chain reaction method targeting non-recombined T-cell receptor sequences aids in diagnosing primary cutaneous T-cell lymphomas Full text PDF
Research Paper Single-cell Transcriptomics Uncovers the Tumor Microenvironment and Collagen-CD44 Axis in HIV Positive Cervical Squamous Cell Carcinoma Full text PDF
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GPCRs interaction with LGR5: Implications to cancer stemness
Background/Objectives: The central role of G-protein coupled receptors (GPCRs) in tumor biology is becoming acknowledged. Yet their involvement in cancer stem cells (CSCs) niche is unknown. Molecular mechanisms of CSCs allow self-formation capacity, resistance to chemotherapy and immune therapy. Methods: Western blots, Co-immunoprecipitation (co-IP) analysis, RT-PCR, Lef/Tcf luciferase activity and Alpha Fold3 HANDDOCK v2.4 protein-protein docking ...
tsRNA's Biological Function and its Potential Application in Disease Diagnosis and Prognosis
Under physiological conditions, tsRNAs regulate mRNA transcription, reverse transcription, and protein translation to mediate cell apoptosis, cell cycle, and epigenetic regulation. Pathogenic tsRNAs are disease-specific or disease-related tsRNAs that are highly express in various diseases and may serve as diagnostic or potential diagnostic biomarkers. Specifically expressed tsRNAs in tumors were screened and obtained from the tumors. Although the ...