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Review Advances in CAR-T Cell Therapy: From Structural Design Innovations to Clinical Translation Challenges Haixia Gao, Yuan Fang, Pingjing Zhang, Qijun Qian J. Cancer 2026; 17(9): 1684-1697. doi:10.7150/jca.134677 Full text PDF


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Review Regulatory roles of E3 ubiquitin ligase RNF128 in inflammatory diseases and tumors Qiuxiang Xiao, Qidong Liu, Jing Wei, Dalang Yu J. Cancer 2026; 17(9): 1671-1683. doi:10.7150/jca.138010 Full text PDF


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Research Paper Integrated Pan-Cancer, Single-Cell, and Spatial Transcriptomic Analyses Identify ZDHHC12 as a Biomarker Associated with Macrophage Infiltration and the Immune Landscape in Glioma Chao Zhang, Da Teng, Yu Wang, Shiqiang Hou, Wenjun Zhang, Ning Lin J. Cancer 2026; 17(9): 1653-1670. doi:10.7150/jca.136931 Full text PDF


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Review Liquid Biopsy and Nonendoscopic Biomarkers for Precision Early Detection of Esophageal Cancer: Evidence, Risk Stratification and Translational Challenges Fangzheng Han, Huaimin Liu J. Cancer 2026; 17(9): 1639-1652. doi:10.7150/jca.140909 Full text PDF


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Research Paper Smoking-Associated Enrichment of CXCL13+ Tfh Cells and VCAM1+ Fibroblasts Is Linked to Tertiary Lymphoid Structure Formation in Lung Adenocarcinoma Yong Jun Choi, Chi Young Kim, Eun Young Kim, Sang Hoon Lee, Min Kyung Park, Yoon Soo Chang J. Cancer 2026; 17(9): 1626-1638. doi:10.7150/jca.138884 Full text PDF


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Research Paper Chronically Established ρ0 Cancer Cells Exhibit Shared Stemness-Associated and Aggressive Phenotypes Across Multiple Cancer Cell Lines Yu-Seon Han, Myeong-Eun Jegal, Su Yeon Lee, Joung-Sun Park, Yung-Jin Kim J. Cancer 2026; 17(9): 1615-1625. doi:10.7150/jca.138124 Full text PDF

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Issue 9; 2026

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Indexed in PubMed and SCI expanded; full texts in Europe PMC. ...


Smoking-Associated Enrichment of CXCL13+ Tfh Cells and VCAM1+ Fibroblasts Is Linked to Tertiary Lymphoid Structure Formation in Lung Adenocarcinoma

Background: Smoking history is associated with improved immune checkpoint inhibitor treatment responses. We investigated smoking-associated differences in the tumor microenvironment (TME) of lung adenocarcinoma (LUAD) and identified biomarkers associated with tertiary lymphoid structure (TLS) formation. Methods: Single-cell RNA-sequencing datasets from tumors and matched adjacent normal tissues from five current smokers and five never-smokers with ...


Regulatory roles of E3 ubiquitin ligase RNF128 in inflammatory diseases and tumors

Ring finger protein 128 (RNF128) belongs to the family of transmembrane E3 ubiquitin (Ub) ligases. It mediates substrate-specific ubiquitination as a critical post-translational modification and regulates diverse physiological activities and pathological processes. More importantly, the E3 Ub ligase RNF128 is involved in both innate and adaptive immune responses through ‌Ub-dependent regulation‌ of its target proteins. Dysregulation of ...

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