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Research Paper Vemurafenib Induces Apoptosis via JNK Activation and AKT Inhibition in Hepatocellular Carcinoma Full text PDF
Research Paper Serum Thyroid Biomarkers for Diagnosing Malignant Thyroid Nodules: A Machine Learning Approach with External and Causal Validation Full text PDF
Research Paper MRI-Based Habitat Radiomics for Differentiating Early-Stage Endometrial Carcinoma from Submucous Leiomyoma: A Multicenter Validation Study Full text PDF
Research Paper Integrative Bulk and Single-Cell Transcriptome Profiling of Telomere-Related Genes Reveals a Robust Prognostic Signature and Immunotherapeutic Landscape in Neuroblastoma Full text PDF
Research Paper Ganoderma lucidum alcohol extract targets mutant p53 signaling to inhibit proliferation in triple-negative breast brain metastasis cancer Full text PDF
Research Paper Functional Stratification and Long-Term Care Service Patterns among Discharged Patients with Cancer: A Retrospective Study from Taiwan Full text PDF
Issue 5; 2026
Indexed in PubMed and SCI expanded; full texts in Europe PMC. ...
Vemurafenib Induces Apoptosis via JNK Activation and AKT Inhibition in Hepatocellular Carcinoma
Background: Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer and remains one of the leading contributors to cancer-related mortality worldwide, primarily due to the disease's therapeutic resistance and marked tumor heterogeneity. Among the molecular mechanisms implicated in HCC progression, the dysregulation of the JNK and PI3K/AKT signaling pathways plays a critical role in tumor initiation, cell proliferation, and cell ...
Purpose: Neuroblastoma (NB) is the most common extracranial solid tumor in children with poor overall survival. Increasing evidence indicates that telomeres contribute to tumorigenesis and influence cancer prognosis. However, the biological and clinical implications of telomere-related genes (TRGs) in NB remain poorly defined. Materials and Methods: We integrated data from multiple independent cohorts to elucidate the roles of TRGs in NB. Differential ...