Impact Factor ISSN: 1837-9664
Research Paper Bevacizumab or Aflibercept in Combination with Second-Line FOLFIRI after Progression on FOLFOX Plus Bevacizumab in Metastatic Colorectal Cancer: A Comparative Study Full text PDF
Review Urine-derived induced pluripotent stem cells for non-invasive diagnosis of bladder cancer Full text PDF
Research Paper Associations of HMGA2 single-nucleotide polymorphisms with clinicopathological features of tongue squamous cell carcinoma in Taiwanese men with distinct lifestyle-related risk factors Full text PDF
Research Paper Separability of histopathology foundation model embeddings of stimulated Raman histology images for lung carcinoma subtyping Full text PDF
Review Advances in CAR-T Cell Therapy: From Structural Design Innovations to Clinical Translation Challenges Full text PDF
Review Regulatory roles of E3 ubiquitin ligase RNF128 in inflammatory diseases and tumors Full text PDF
Issue 9; 2026
Indexed in PubMed and SCI expanded; full texts in Europe PMC. ...
Background: The optimal anti-angiogenic strategy in the second-line treatment of metastatic colorectal cancer (mCRC) after progression on first-line FOLFOX plus bevacizumab remains unclear. We aimed to compare the efficacy and safety of FOLFIRI combined with bevacizumab or aflibercept in this well-defined clinical setting. Methods: In this retrospective single-center study, 152 patients with mCRC who progressed after at least four cycles of first-line ...
Regulatory roles of E3 ubiquitin ligase RNF128 in inflammatory diseases and tumors
Ring finger protein 128 (RNF128) belongs to the family of transmembrane E3 ubiquitin (Ub) ligases. It mediates substrate-specific ubiquitination as a critical post-translational modification and regulates diverse physiological activities and pathological processes. More importantly, the E3 Ub ligase RNF128 is involved in both innate and adaptive immune responses through Ub-dependent regulation of its target proteins. Dysregulation of ...