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Research Paper Hadhb Deficiency Inhibits Lung Tumorigenesis Via Activating ER Stress Full text PDF
Research Paper Phenotypic risk factors linked to acute radiation-induced toxicities: a phenome-wide Mendelian randomization study of 12,042 cancer patients Full text PDF
Research Paper Exploratory Serum Metabolomics Identifies Metabolic Subgroups Across the Gastric Dysplasia-Early Cancer Spectrum Full text PDF
Review The Role of Traditional Chinese Medicine in Metabolic Reprogramming, Tumor microenvironment, and Macrophage Regulation: Mechanisms and Advances in Preclinical Studies Full text PDF
Research Paper Determination of protein markers of inflammasome formation and ferroptosis in thyroid cancer based on gender Full text PDF
Review Anticancer Effects of Cepharanthine: an Updated Minireview Full text PDF
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Hadhb Deficiency Inhibits Lung Tumorigenesis Via Activating ER Stress
Lung cancer remains the leading cause of cancer-related mortality worldwide, yet its molecular pathogenesis is not fully understood. Here, we identify HADHB, encoding a mitochondrial β-ketothiolase as a novel oncogene in lung cancer. Using a HadhbPB/PB mouse model, we demonstrate that Hadhb deficiency in mice significantly suppresses K-RasG12D-driven lung tumor progression by impairing cancer cell proliferation and enhancing apoptosis. Mechanistically, ...
Objective: This study aims to systematically evaluate phenome-wide clinical factors contributing to radiation-induced toxicities (RITs) and provide evidence to identify acute RITs-associated risk factors for personalized radiation treatment stratification. Methods: Leveraging genome-wide association study data from 12,042 patients with prostate, head and neck, breast, or lung cancer, we conducted MR-PheWAS (phenome-wide association study integrated ...