Impact of vaccination against COVID-19 on patients with cancer in ACHOC-C19 study: Real world evidence from one Latin American country

Ospina, Aylen Vanessa; Brugés, Ricardo; Triana, Iván; Sánchez-Vanegas, Guillermo; Barrero, Angela; Mantilla, William; Ramos, Pedro; Bernal, Laura; Aruachán, Sandra; González, Manuel; Lobatón, José; Quiroga, Alicia; Rivas, Giovanna; González, Guido; Lombana, Milton; Munevar, Isabel; Jiménez, Paola; Avendaño, Ana Cristina; Arias, Mirian Caicedo; López, Carolina; González, Héctor; Pacheco, Javier; Manneh, Ray; Pinilla, Paola; Russi, Andrea; Ortiz, Juan; Insuasty, Jesús; Alcalá, Carmen; Contreras, Fernando; Bogoya, Juliana

doi:10.7150/jca.79969

International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

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J Cancer 2023; 14(13):2410-2416. doi:10.7150/jca.79969 This issue Cite

Research Paper

Impact of vaccination against COVID-19 on patients with cancer in ACHOC-C19 study: Real world evidence from one Latin American country

Aylen Vanessa Ospina^1✉, Ricardo Brugés², Iván Triana¹, Guillermo Sánchez-Vanegas³, Angela Barrero⁴, William Mantilla⁵, Pedro Ramos⁶, Laura Bernal⁷, Sandra Aruachán⁸, Manuel González⁸, José Lobatón⁸, Alicia Quiroga⁹, Giovanna Rivas¹⁰, Guido González¹⁰, Milton Lombana¹⁰, Isabel Munevar¹¹, Paola Jiménez¹², Ana Cristina Avendaño¹³, Mirian Caicedo Arias¹³, Carolina López¹³, Héctor González¹⁴, Javier Pacheco¹⁵, Ray Manneh¹⁶, Paola Pinilla¹⁶, Andrea Russi¹⁷, Juan Ortiz¹⁸, Jesús Insuasty¹⁹, Carmen Alcalá²⁰, Fernando Contreras²¹, Juliana Bogoya²²

1. ICCAL Fundación Santa Fe de Bogotá. Asociación Colombiana de Hematología y Oncología - ACHO.
2. Instituto Nacional de Cancerología - Pontificia Universidad Javeriana.
3. Hospital Universitario Mayor - Mederí. Universidad del Rosario.
4. Asociación Colombiana de Hematología y Oncología - ACHO. Instituto Nacional Cancerología.
5. Fundación Cardio infantil, Universidad del Rosario, Grupo ICAROS.
6. Clínica Universitaria Colombia Sanitas.
7. Clínica Universitaria Colombia Sanitas - Clínica Marly.
8. IMAT Oncomédica.
9. Hospital Pablo Tobón Uribe.
10. Centro Médico Clínica de Occidente.
11. Hospital Militar Central, Fundación Cardioinfantil. Hemato Oncólogos Asociados.
12. Hospital Militar Central, Hemato Oncólogos Asociados.
13. Hemato Oncólogos Asociados, Instituto de Oncología.
14. CECANCOL.
15. Hospital de San José.
16. Sociedad de Oncología y Hematología del Cesar.
17. Hospital Universitario San Ignacio.
18. Hospital Universitario del Valle.
19. Hospital Universitario de Santander - Universidad Industrial de Santander.
20. Clínica de la Costa.
21. Instituto Nacional Cancerología. Universidad El Bosque.
22. Instituto Nacional Cancerología.

Citation:

Ospina AV, Brugés R, Triana I, Sánchez-Vanegas G, Barrero A, Mantilla W, Ramos P, Bernal L, Aruachán S, González M, Lobatón J, Quiroga A, Rivas G, González G, Lombana M, Munevar I, Jiménez P, Avendaño AC, Arias MC, López C, González H, Pacheco J, Manneh R, Pinilla P, Russi A, Ortiz J, Insuasty J, Alcalá C, Contreras F, Bogoya J. Impact of vaccination against COVID-19 on patients with cancer in ACHOC-C19 study: Real world evidence from one Latin American country. J Cancer 2023; 14(13):2410-2416. doi:10.7150/jca.79969. https://www.jcancer.org/v14p2410.htm

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Abstract

Introduction: During the pandemic, it has been recommended that vaccination against COVID-19 be a priority for patients with cancer; however, these patients were not included in the initial studies evaluating the available vaccines.

Objective: To define the impact of vaccination against COVID-19 in preventing the risk of complications associated with the infection in a cohort of patients with cancer in Colombia.

Methods: An analytical observational cohort study, based on national registry of patients with cancer and COVID 19 infection ACHOC-C19, was done. The data was collected from June 2021, until October 2021. Inclusion criteria were: Patients older than 18 years with cancer diagnosis and confirmed COVID-19 infection. Data from the unvaccinated and vaccinated cohorts were compared. Outcomes evaluated included all-cause mortality within 30 days of COVID-19 diagnosis, hospitalization, and need for mechanical ventilation. The estimation of the effect was made through the relative risk (RR), the absolute risk reduction (ARR) and the number needed to treat (NNT). Multivariate analysis was performed using generalized linear models.

Results: 896 patients were included, of whom 470 were older than 60 years (52.4%) and 59% were women (n=530). 172 patients were recruited in the vaccinated cohort and 724 in the non-vaccinated cohort (ratio: 1 to 4.2). The cumulative incidence of clinical outcomes among the unvaccinated vs vaccinated patients were: for hospitalization 42% (95% CI: 38.7%-46.1%) vs 29%; (95% CI: 22.4%-36.5%); for invasive mechanical ventilation requirement 8.4% (n=61) vs 4.6% (n=8) and for mortality from all causes 17% (n=123) vs 4.65% (n=8).

Conclusion: In our population, unvaccinated patients with cancer have an increased risk of complications for COVID -19 infection, as hospitalization, mechanical ventilation, and mortality. It is highly recommended to actively promote the vaccination among this population.

Keywords: COVID-19, vaccines, cancer, vaccine effectiveness, cohort studies, mortality, mechanical ventilation, hospitalization

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APA

Ospina, A.V., Brugés, R., Triana, I., Sánchez-Vanegas, G., Barrero, A., Mantilla, W., Ramos, P., Bernal, L., Aruachán, S., González, M., Lobatón, J., Quiroga, A., Rivas, G., González, G., Lombana, M., Munevar, I., Jiménez, P., Avendaño, A.C., Arias, M.C., López, C., González, H., Pacheco, J., Manneh, R., Pinilla, P., Russi, A., Ortiz, J., Insuasty, J., Alcalá, C., Contreras, F., Bogoya, J. (2023). Impact of vaccination against COVID-19 on patients with cancer in ACHOC-C19 study: Real world evidence from one Latin American country. Journal of Cancer, 14(13), 2410-2416. https://doi.org/10.7150/jca.79969.

ACS

Ospina, A.V.; Brugés, R.; Triana, I.; Sánchez-Vanegas, G.; Barrero, A.; Mantilla, W.; Ramos, P.; Bernal, L.; Aruachán, S.; González, M.; Lobatón, J.; Quiroga, A.; Rivas, G.; González, G.; Lombana, M.; Munevar, I.; Jiménez, P.; Avendaño, A.C.; Arias, M.C.; López, C.; González, H.; Pacheco, J.; Manneh, R.; Pinilla, P.; Russi, A.; Ortiz, J.; Insuasty, J.; Alcalá, C.; Contreras, F.; Bogoya, J. Impact of vaccination against COVID-19 on patients with cancer in ACHOC-C19 study: Real world evidence from one Latin American country. J. Cancer 2023, 14 (13), 2410-2416. DOI: 10.7150/jca.79969.

NLM

CSE

Ospina AV, Brugés R, Triana I, Sánchez-Vanegas G, Barrero A, Mantilla W, Ramos P, Bernal L, Aruachán S, González M, Lobatón J, Quiroga A, Rivas G, González G, Lombana M, Munevar I, Jiménez P, Avendaño AC, Arias MC, López C, González H, Pacheco J, Manneh R, Pinilla P, Russi A, Ortiz J, Insuasty J, Alcalá C, Contreras F, Bogoya J. 2023. Impact of vaccination against COVID-19 on patients with cancer in ACHOC-C19 study: Real world evidence from one Latin American country. J Cancer. 14(13):2410-2416.

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