Volume 17, Issue 3

open access Global reach, higher impact

Volume 17 (3); 2026

Research Papers

C4orf3 Regulates HIF-1α Degradation Under Hypoxic Conditions and Contributes to the Malignant Phenotype in Small Cell Lung Cancer
Keita Sakanashi, Hideya Onishi, Naoya Iwamoto, Yoshiyuki Nakanishi, Shinsaku Itoyama, Shogo Masuda, Keigo Ozono, Kosuke Yanai, Katsuya Nakamura, Masayo Nagami, Kenichi Nishiyama, Masayuki Kojima, Yoshinao Oda, Masafumi Nakamura
J. Cancer 2026; 17(3): 457-468. doi:10.7150/jca.127942
Full text PDF

Mapping Myeloid Cell Diversity in Diffuse Large B-Cell Lymphoma: Impact on T Cell Exhaustion and Clinical Prognosis
Jingwen Wang, Liangcheng Lv, Zhenjun Li, Xiaoyu Yao, Ning Ding
J. Cancer 2026; 17(3): 469-482. doi:10.7150/jca.121954
Full text PDF

RNF216 as a Promising Biomarker for Prognosis, Immunotherapy, and Chemotherapy in LIHC: A Comprehensive Pan-Cancer Analysis and Experimental Validation
Ke Du, Xiao Liang, Bowen Qin, Zitao Liu, Nanbin Liu, Pincheng Li, Qian Wang, Yajie Qi, Enze Shi, Kun Li
J. Cancer 2026; 17(3): 483-506. doi:10.7150/jca.125407
Full text PDF

Clinical Outcomes and Individualized Seed Implantation Planning for Iodine-125 Seeds Brachytherapy in Lymph Node Metastases
Dongcun Huang, Zhihui Zhong, Fujun Zhang, Letao Lin
J. Cancer 2026; 17(3): 507-514. doi:10.7150/jca.126692
Full text PDF

FBXW7 suppresses cell proliferation, migration, and epithelial-mesenchymal transition in endometrioid ovarian carcinoma
Ching-Chou Tsai, Chia-Yi Hsu, Jau-Ling Suen, Hung-Pin Tu, Kun-Bow Tsai, Shun-Chen Huang, Yu-Che Ou, Eing-Mei Tsai
J. Cancer 2026; 17(3): 555-563. doi:10.7150/jca.128606
Full text PDF

Potential influence of omentin-1 genetic variants on the clinicopathological features of patients with hepatocellular carcinoma
Sung-Lin Hu, Hsiang-Lin Lee, Ming-Yu Lien, Edie-Rosmin Wu, Shun-Fa Yang, Chih-Hsin Tang
J. Cancer 2026; 17(3): 564-570. doi:10.7150/jca.128357
Full text PDF

Proteasome Assembly Chaperone 3 Defines Metabolic-Immune Programs and Poor Prognosis in Breast Cancer via Multi-Omics Approaches
Sachin Kumar, Hoang Dang Khoa Ta, Hao-Chien Yang, Chia-Lung Shih, Dahlak Daniel Solomon, Ching-Chung Ko, Do Thi Minh Xuan, Yung-Kuo Lee, Kai-Fu Chang, Hui-Ru Lin, Shu-Huei Kao, Jian-Ying Chuang, Jian-Bin Chen, Chih-Yang Wang, Ngoc Uyen Nhi Nguyen
J. Cancer 2026; 17(3): 583-603. doi:10.7150/jca.126116
Full text PDF

Impact of Skeletal Muscle-related Parameters on Survival in Patients with Advanced Pancreatic Cancer Treated with Gemcitabine plus Nab-paclitaxel as First-line Chemotherapy
Nanako Matsuo, Toshifumi Yamaguchi, Hiroki Yukami, Hiroyuki Kodama, Takako Ikegami, Toru Kadono, Shin Kameisihi, Dai Okemoto, Elham Fakhrejahani, Hiroki Nishikawa
J. Cancer 2026; 17(3): 604-613. doi:10.7150/jca.126673
Full text PDF

FAM188B promotes progression of hepatocellular carcinoma by regulating YAP/TAZ via interaction with USP10
Siwei Hu, Yuting Wen, Yihong Chen, Yuliang Fang, Mingshan Mu, Linglan Tu, Wenhu Chen, Kangsheng Tu, Xin Liu, Qiuran Xu, Dongsheng Huang, Xiaoyan Li
J. Cancer 2026; 17(3): 626-636. doi:10.7150/jca.125659
Full text PDF

Recurrence of Adult Granulosa Cell Tumors: The Factors Affecting Secondary Recurrence and Survival After Recurrence
Hasan Volkan Ege, Derman Başaran, Murat Gültekin, Nejat Özgül, Nurattin Boran, Sevgi Koç, Yaprak Üstün, Caner Çakır, Dilek Yüksel, Okan Oktar, Gökçen Ege, Abdurrahman Alp Tokalıoğlu, Mustafa Şahin, Yeşim Uçar, Fatih Kılıç, Okan Aytekin, Burak Ersak, Mehmet Ünsal, Özlem Moraloğlu Tekin, Çiğdem Kılıç, Özgür Koçak, Çağatayhan Öztürk, Salih Taşkın, Fırat Ortaç, Işın Üreyen, Tayfun Toptaş, Sevda Baş, Mehmet Ali Narin, Tolga Taşçı, Gökhan Uçar, Mehmet Ali Şendur, Burak Civelek, Doğan Uncu, Özgür Erdoğan, Muzaffer Sancı, Hakan Raşit Yalçın, İlker Selçuk, Taner Turan
J. Cancer 2026; 17(3): 637-645. doi:10.7150/jca.127596
Full text PDF

Integrative analysis of lysosome-dependent cell death related molecular subtypes and prognosis prediction in papillary thyroid carcinoma
Ying Xu, Qiong Wang, Na Zhang, Fugeng He, Xiaochun Mao
J. Cancer 2026; 17(3): 646-661. doi:10.7150/jca.129191
Full text PDF

Integrative Multi-Omics and Single-Cell Profiling Identify Chitinase Domain Containing Protein 1 (CHID1) as a Prognostic Biomarker in Glioblastoma
Sachin Kumar, Chung-Che Wu, Dahlak Daniel Solomon, Juan Lorell Ngadio, Do Thi Minh Xuan, Ching-Chung Ko, Neethu Palekkode, Ayman Fathima, Hung-Yun Lin, Hui-Ru Lin, Chih-Yang Wang, Yung-Kuo Lee, Ngoc Uyen Nhi Nguyen
J. Cancer 2026; 17(3): 662-678. doi:10.7150/jca.130519
Full text PDF

A CRM-Integrated ypT Staging System Improves Prognostic Stratification Following Neoadjuvant Therapy in Rectal Cancer
Wan-Hsuan Chow, Chung-Han Ho, Yi-Chen Chen, Hsuan-Yi Huang, Ching-Chieh Yang
J. Cancer 2026; 17(3): 679-687. doi:10.7150/jca.129779
Full text PDF

Reviews

Spatial Omics in Gastrointestinal Oncology: Recent Advances, Therapeutic Insights, and Clinical Translation
Lin Zhong, Qian Li, Ting Xiong, Shengzheng Lin, Kaining Wang, Guanying Li, Ye Yan, Jianhao Liu, Chuansong Xue
J. Cancer 2026; 17(3): 515-523. doi:10.7150/jca.127381
Full text PDF

A Comprehensive Review of Nanotechnological Innovations in Cancer: from Molecular Pathways to Clinical Applications
Saqib Nawaz, Wei Ho, Asif Nawaz, Sajid Ur Rahman, Ayesha Zahid, Khalid J. Alzahrani, Ibrahim F. Halawani, Fuad M. Alzahrani, Chien-Chin Chen, Abdul Qadeer
J. Cancer 2026; 17(3): 524-541. doi:10.7150/jca.126813
Full text PDF

MZB1 at the ER-immunity interface: from antibody folding to disease vulnerability in autoimmunity, inflammation, and cancer
Yu Zhang, Wei Yang, Xiaofang Yang, Yuqing Pan, Rong Guo, Dong Chen, Shicong Tang, Xi Zhang
J. Cancer 2026; 17(3): 542-554. doi:10.7150/jca.125922
Full text PDF

Molecular Mechanisms of Symptom Fluctuations in Malignant Tumor Patients: Stable by Day and Severe at Night
Zhongxuan Xie, Wei Jin, Juezhou Pang, Kangshuo Hu, Lihong Li
J. Cancer 2026; 17(3): 571-582. doi:10.7150/jca.128423
Full text PDF

Fluid-Derived Organoids from Pleural Effusion and Ascites: Emerging Models for Drug Resistance and Personalized Oncology
Yongyang Chen, Xiaoqing Xu, Jialin Chen, Miao Yin, Jinhui Chen, Zhanghua Qi, Ming Shi, Wenmei Su
J. Cancer 2026; 17(3): 614-625. doi:10.7150/jca.127511
Full text PDF