Volume 16, Issue 4

open access Global reach, higher impact

Volume 16 (4); 2025

Editorial

The Second Selectivity of Taxanes to Malignant Cells --- Nuclear Envelope Malleability
Xiang-Xi Xu, Elizabeth R. Smith
J. Cancer 2025; 16(4): 1051-1053. doi:10.7150/jca.104809
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Research Papers

Lymph Node Ratio (LNR) Discriminates Prognostication in pN1a-b and pN2 Stage-III Colon Cancer
Erman Akkus, Mehmet Kayaalp, Beliz Bahar Karaoğlan, Cihangir Akyol, Güngör Utkan
J. Cancer 2025; 16(4): 1032-1039. doi:10.7150/jca.104336
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Characteristics and function of the gut microbiota in patients with rectal neuroendocrine tumors
Yue Gao, Hongxia Zheng, Mujie Ye, Guozhi Zhou, Jinhao Chen, Xinyun Qiang, Jianan Bai, Xintong Lu, Qiyun Tang
J. Cancer 2025; 16(4): 1040-1050. doi:10.7150/jca.103297
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Metformin Against Herpes Zoster in Colon Cancer Patients with Type 2 Diabetes: A PSM Analysis
Ming-Chang Li, Wan-Ming Chen, Ben-Chang Shia, Szu-Yuan Wu
J. Cancer 2025; 16(4): 1054-1065. doi:10.7150/jca.98852
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S100A8 promotes the proliferation, migration and invasion in bladder cancer cells
Hao-ran Xu, Zhen Pang, Qin-zhang Wang, Song Ou-Yang
J. Cancer 2025; 16(4): 1066-1077. doi:10.7150/jca.102201
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Training and experimental validation a novel anoikis- and epithelial‒mesenchymal transition-related signature for evaluating prognosis and predicting immunotherapy efficacy in gastric cancer
Cheng Zeng, Chang Xu, Yuhan Wei, Fei Ma, Yue Wang
J. Cancer 2025; 16(4): 1078-1100. doi:10.7150/jca.106029
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LDH Isoenzyme and GAA-BSA Nanoparticles: A Novel Therapy Approach for Proneural Subtype Glioblastoma Multiforme
Mengting Yang, Xiu Han, Hongxu Li, Fengyi Du, Chunlai Feng, Aihua Gong
J. Cancer 2025; 16(4): 1101-1117. doi:10.7150/jca.98452
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CT Urography-Based Radiomics to Predict ISUP Grading of Clear Cell Renal Cell Carcinoma
Panpan Jiao, Bin Wang, Xinmiao Ni, Yi Lu, Rui Yang, Yunxun Liu, Jingsong Wang, Haonan Mei, Xiuheng Liu, Xiaodong Weng, Qingyuan Zheng, Zhiyuan Chen
J. Cancer 2025; 16(4): 1118-1126. doi:10.7150/jca.105173
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Pan-Cancer Analysis of KANK2: Clinical and Molecular Insights into Tumor Progression and Therapeutic Implications
Kai Zhao, Jie Lin, Yongzhi Li, Shenghao Xu, Fei Wang, Yongsheng Yang
J. Cancer 2025; 16(4): 1149-1166. doi:10.7150/jca.105098
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Integrating of Radiomics and Single-cell Transcriptomics Uncovers the Crucial Role of γδ T Cells in Lung Adenocarcinoma
Ziyi Chen, Changqing Yang, Jiajing Wang, Baichuan Wang, Long He, Zhaoyi Liu, Yingxi Li, Tingting Qin, Peng Chen
J. Cancer 2025; 16(4): 1167-1180. doi:10.7150/jca.105586
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Neoadjuvant Chemotherapy Can Effectively Avoid Unnecessary Extended Resection for Gastric Cancer with Clinical Evidence of Duodenum or Pancreas Head Involvement
Qianna Jin, Jiaqing Cao, Guobin Wang, Nan He
J. Cancer 2025; 16(4): 1181-1188. doi:10.7150/jca.105534
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A Novel Nomogram for the Prediction and Evaluation of Prognosis in Patients with Early-onset Kidney Cancer: a Population-based Study
Dingyang Lv, Qiwei Wang, Ke Sun, Jinshuai Li, Huiyu Zhou, Jie Wen, Weibing Shuang
J. Cancer 2025; 16(4): 1189-1201. doi:10.7150/jca.104569
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HOXC-AS1 and EZH2 interaction increase HOXC9 expression and promote the malignant transformation of oral leukoplakia
Xiaochuan Chen, Jiusong Han, Shuhua Li, Xi Yang, Shuyu Yang, Chenrong Xu, Xueyi Liang
J. Cancer 2025; 16(4): 1202-1214. doi:10.7150/jca.103482
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AURKC Promotes Clear Cell Renal Cell Carcinoma Proliferation Through Upregulation of ERp57
Yan Liu, Yue Wen, Ziyuan Nie, Li Jia
J. Cancer 2025; 16(4): 1215-1227. doi:10.7150/jca.103134
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Establishment of a Basement Membrane-Related Prognosis Model and Characterization of Tumor Microenvironment Infiltration in Acute Myeloid Leukemia
Zongsi Zhu, Yuedong Zhao, Ping Li
J. Cancer 2025; 16(4): 1228-1242. doi:10.7150/jca.108041
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Integrated Multi-omics Data Analysis and In Vitro Validation Reveal the Crucial Role of Glycogen Metabolism in Gastric Cancer
Xin Zhou, Jing Wu, Yaoyao Liu, Xiaping Wang, Xuan Gao, Xuefeng Xia, Jing Xu, Jing He, Tongshan Wang, Yongqian Shu
J. Cancer 2025; 16(4): 1243-1263. doi:10.7150/jca.104424
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Single-cell and Multi-omics Analysis Confirmed the Signature and Potential Targets of Cuproptosis in Colorectal Cancer
Tao Jiang, Zijing Wang, Zhanyuan Sun, Hengyi Lv, Guo Li, Hai Li
J. Cancer 2025; 16(4): 1264-1280. doi:10.7150/jca.104702
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Exploring breast cancer associated-gene panel for next-generation sequencing and identifying new, pathogenic variants in breast cancer from western China
Jingliang Cheng, Binghui Song, Chunli Wei, Lianmei Zhang, Xiaoyan Liu, Lisha Yang, Singkome Tima, Sawitree Chiampanichayakul, Xiuli Xiao, Songyot Anuchapreeda, Junjiang Fu
J. Cancer 2025; 16(4): 1281-1295. doi:10.7150/jca.101911
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The clinical impact of galectin-8 in drug resistant breast cancer
Yi-Chung Chien, Jia-Yan Wu, Chi-Chun Pang, Ruey-Hwang Chou, Yung-Luen Yu
J. Cancer 2025; 16(4): 1296-1309. doi:10.7150/jca.104000
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TGF-β secreted by cancer cells-platelets interaction activates cancer metastasis potential by inducing metabolic reprogramming and bioenergetic adaptation
Chunlian Zhong, Weiyu Wang, Yinyin Yao, Shu Lian, Xiaodong Xie, Judan Xu, Shanshan He, Lin Luo, ZhouZhou Ye, Jiajie Zhang, Mingqing Huang, Guihua Wang, Yanhong Wang, Yusheng Lu, Chengbin Fu
J. Cancer 2025; 16(4): 1310-1323. doi:10.7150/jca.103757
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Matrix stiffness regulates NPC invasiveness by modulating a mechanoresponsive TRPV4-Nox4-IL-8 signaling axis
Peng Zhang, Dunhui Yang, Kang Li, Jin Zhang, Zhen Wang, Fang Ma, Xianqin Liao, Shibo Ma, Xianhai Zeng, Xiangmin Zhang
J. Cancer 2025; 16(4): 1324-1334. doi:10.7150/jca.104235
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NEK6 functions as an oncogene to promote the proliferation and metastasis of ovarian cancer
Sainan Gao, Min Su, Tingting Bian, Yifei Liu, Yanhua Xu, Yuquan Zhang
J. Cancer 2025; 16(4): 1335-1346. doi:10.7150/jca.103769
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EFHD1 Activates SIK3 to Limit Colorectal Cancer Initiation and Progression via the Hippo Pathway
Qionghui Huang, Xiaoyan Tang, Caiyan Gan, Qiaoting Deng, Shaobin Zhi, Qingyan Huang, Xiaoqi Zheng, Xueqiong Li, Zengfeng Pan, Mingfeng Huang
J. Cancer 2025; 16(4): 1348-1362. doi:10.7150/jca.103229
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Multi-omics analysis of core E3 ubiquitin ligase identifies prognostic biomarkers associated with immune infiltration and drug sensitivity in lung adenocarcinoma
Yuan-Xiang Shi, Jia Wang, Zhen-Lin Jiang, Jian-Hua Yan
J. Cancer 2025; 16(4): 1363-1378. doi:10.7150/jca.104837
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Risk Prediction of Myelosuppression Following First-line Chemotherapy in Colorectal Cancer
Yanyuan Du, Yuming Liu, Ruiying Fang, Liu Cai, Ying Song, Susu Ma, Huibo Yu, Jin Gao, Hongtai Xiong, Hanyue Zhang, Baihui Li, Honggang Zheng
J. Cancer 2025; 16(4): 1379-1396. doi:10.7150/jca.104412
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Integration of Single-Cell and Bulk Transcriptomes to Identify a Poor Prognostic Tumor Subgroup to Predict the Prognosis of Patients with Early-stage Lung Adenocarcinoma
Zijian Shi, Linchuang Jia, Baichuan Wang, Shuo Wang, Long He, Yingxi Li, Guixin Wang, Wenbin Song, Xianneng He, Zhaoyi Liu, Cangchang Shi, Yao Tian, Keyun Zhu
J. Cancer 2025; 16(4): 1397-1412. doi:10.7150/jca.105926
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Reviews

Implantable Port Catheters versus Peripherally Inserted Central Catheters for Cancer Patients Requiring Chemotherapy: An RCT-Based Meta-Analysis
Juan Qiu, Shanshan Huang, Pei Wen, Yingxin Jiang, Zan Luo, Wenxiong Zhang, Jianyun Wen
J. Cancer 2025; 16(4): 1127-1136. doi:10.7150/jca.103631
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The regulatory role and therapeutic potential of long non-coding RNA in non-small cell lung cancer
Sunming Xia, Xuean Lu, Weier Wang, Xinyi Pan, Jiaqi Cui, Shengjie Wang, Zhao Wang
J. Cancer 2025; 16(4): 1137-1148. doi:10.7150/jca.103182
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Retraction

HER4 Promotes Osteosarcoma Progression and Predicts Poor Prognosis through the PTEN-PI3K/AKT Pathway: Retraction
Kun Ma, Chuan Zhang
J. Cancer 2025; 16(4): 1347. doi:10.7150/jca.110321
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