Online advance articles

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Extranodal extension in bilateral cervical metastases: a predictor of undesirable survival outcomes despite aggressive salvage treatment in oral cancer patients
Weijin Gao, Yuhua Hu, Dan Zhu, Xiaoguang Li, Bing Guo, Yi Shen, Chunyue Ma, Juan Du
J. Cancer 2021; doi:10.7150/jca.60152; accepted
[Author manuscript]

Identification of a prognostic 4-mRNA signature in laryngeal squamous cell carcinoma
Cheng Zhang, Bin Shen, Xinwei Chen, Shang Gao, Xinjiang Ying, Pin Dong
J. Cancer 2021; doi:10.7150/jca.47557; accepted
[Author manuscript]

Cost Effectiveness of PET-CT vs CT Thorax for EBUS-TBNA 22G vs 19G: Mesothorax Lymphadenopathy
Paul Zarogoulidis, Dimitris Petridis, Kosmas Tsakiridis, Dimitris Matthaios, Haidong Huang, Chong Bai, Konstantinos Sapalidis, Christoforos Kosmidis, Wolfgang Hohenforst-Schmidt, Christos Tolis, Ioannis Boukovinas, Chrysanthi Karapantzou
J. Cancer 2021; doi:10.7150/jca.59892; accepted
[Author manuscript]

High Expression of RhoF Predicts Worse Overall Survival: A Potential Therapeutic Target for non-M3 Acute Myeloid Leukemia
Yue Hou, Jie Zi, Zheng Ge
J. Cancer 2021; doi:10.7150/jca.52648; in press
[Author manuscript]

Anti-proliferative, pro-apoptotic and anti-invasive effect of the copper coordination compound Cas III-La through the induction of reactive oxygen species and regulation of Wnt/β-catenin pathway in glioma
Rosa Angélica Castillo-Rodríguez, Guadalupe Palencia, Isabel Anaya-Rubio, Juan Carlos Gallardo- Pérez, Dolores Jiménez-Farfán, Ángel Escamilla-Ramírez, Sergio Zavala-Vega, Arturo Cruz-Salgado, Claudia Cervantes-Rebolledo, Isabel Gracia-Mora, Lena Ruiz-Azuara, and Cristina Trejo-Solis
J. Cancer 2021; doi:10.7150/jca.59769; in press
[Author manuscript]

When to apply immune checkpoint inhibitor in patients with refractory advanced gastric cancer
Hongsik Kim, Hana Kim, Minsang Lee, Minsuk Kwon, Jung Yong Hong, Jeeyun Lee, Ho Yeong Lim, Won Ki Kang and Seung Tae Kim
J. Cancer 2021; doi:10.7150/jca.62853; in press
[Author manuscript]

Cold atmospheric plasma selectively induces G0/G1 cell cycle arrest and apoptosis in AR-independent prostate cancer cells
Dong Hua, Dongyan Cai, Meng Ning, Lihui Yu, Zhifa Zhang, Peiyu Han, Xiaofeng Dai
J. Cancer 2021; doi:10.7150/jca.54528; accepted
[Author manuscript]

Research progress, challenges and perspectives on PNPLA3 and Its Variants in Liver Diseases
Hongjiao Xiang, Zecheng Wu, Junmin Wang, Tao Wu
J. Cancer 2021; doi:10.7150/jca.57951; accepted
[Author manuscript]

SNX-2112 Induces Apoptosis and Inhibits Proliferation, Invasion, and Migration of Non-Small Cell Lung Cancer by Downregulating Epithelial-Mesenchymal Transition via the Wnt/β-Catenin Signaling Pathway
Xiaozhen Cheng, Lingyu Qin, Lian Deng, Xiongjie Zhu, Ying Li, Xiaoran Wu, Yanfang Zheng
J. Cancer 2021; doi:10.7150/jca.56640; accepted
[Author manuscript]

Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis
Yuanyuan Zeng, Jie Zhang, Mengmeng Xu, Fuxian Chen, Ruidong Zi, Jicheng Yue, Ya'nan Zhang, Nannan Chen, Y. Eugene Chin
J. Cancer 2021; doi:10.7150/jca.60170; accepted
[Author manuscript]

Efficacy and mechanism of active fractions in fruit of Amomum villosum Lour. for Gastric Cancer
Jianjun Yue, Shulei Zhang, Bo Zheng, Faisal Raza, Zuhan Luo, Xiaohua Li, Yongyu Zhang, Qu Nie and Mingfeng Qiu
J. Cancer 2021; doi:10.7150/jca.61310; accepted
[Author manuscript]

Effects of microenvironmental biomechanical factors on the biological characteristics of cancer stem cells
Boren Tian, Weifan Lin, Yan Zhang
J. Cancer 2021; doi:10.7150/jca.60893; accepted
[Author manuscript]

The functional role of Pescadillo ribosomal biogenesis factor 1 in cancer
Yong-Zhi Li, Cheng Zhang, Jun-Peng Pei, Wan-Chuan Zhang, Chun-Dong Zhang, Dong-Qiu Dai
J. Cancer 2021; doi:10.7150/jca.58982; accepted
[Author manuscript]

S100A1 is a Potential Biomarker for Papillary Thyroid Carcinoma Diagnosis and Prognosis
Ge Wang, Han-ning Li, Xiao-qing Cui, Tao Xu, Meng-lu Dong, Shu-yu Li, Xing-rui Li
J. Cancer 2021; doi:10.7150/jca.51855; in press
[Author manuscript]

Long noncoding RNA VPS9D1-AS1 promotes esophageal squamous cell carcinoma progression through the Wnt/β-catenin signaling pathway
Liang Ma, Wenyue Yan, Xingwei Sun, Ping Chen
J. Cancer 2021; doi:10.7150/jca.54556; accepted
[Author manuscript]

Comprehensive analysis of Transcription Factors identified novel prognosis biomarker in human bladder cancer
Yihao Liao; Xuanxuan Zou; Keke Wang; Youzhi Wang; Miaomiao Wang; Tao Guo; Boqiang Zhong; Ning Jiang
J. Cancer 2021; doi:10.7150/jca.58484; in press
[Author manuscript]

Prognostic Value of Preoperative Albumin-to-Fibrinogen Ratio in Patients with Bladder Cancer
Shuai Li, Di Zhang, Song Zeng, Tianjun Wu, Yicun Wang, He Zhang, Xiaopeng Hu
J. Cancer 2021; doi:10.7150/jca.61068; accepted
[Author manuscript]

SNHG9 Promotes The Hepatoblastoma Tumorigenesis Via miR-23a-5p/Wnt3a axis
Ramesh Bhandari, Sun Gui Feng, Liu Ya, Bian Zhixuan, Pan Qiuhui, Zhu Jiabei, Mao sewi, Zhen Ni, Wang Jing, Ma Ji, Sun Fenyong
J. Cancer 2021; doi:10.7150/jca.60748; accepted
[Author manuscript]

Collagen type 1 alpha 1 chain is a novel predictive biomarker of poor progression-free survival and chemoresistance in metastatic lung cancer
Lingjie Hou, Tie Lin, Yicun Wang, Bao Liu, Meng Wang
J. Cancer 2021; doi:10.7150/jca.59723; in press
[Author manuscript]

Suppression of human colon tumor by EERAC through regulating Notch/DLL4/Hes pathway inhibiting angiogenesis in vivo
Chenchen Yuan, Chenchen Wu, Rong Xue, Chun Jin, Chenguo Zheng
J. Cancer 2021; doi:10.7150/jca.61581; accepted
[Author manuscript]

LncRNA-H19 regulates chemoresistance to carboplatin in epithelial ovarian cancer through microRNA-29b-3p and STAT3
Xueye Tian, Xiaohang Zuo, Meng Hou, Chen Li, Yue Teng
J. Cancer 2021; doi:10.7150/jca.58979; in press
[Author manuscript]

Co-overexpression of RIOK1 and AKT1 as a prognostic risk factor in glioma
Yiwei Wang, Xiaochen Xie, Shu Li, Dongyong Zhang, Min ZhangZhong Zhang
J. Cancer 2021; doi:10.7150/jca.60596; in press
[Author manuscript]

A luminacin D analog HL142 inhibits ovarian tumor growth and metastasis by reversing EMT and attenuating the TGFβ and FAK pathways
Baojin Wang, Hanxuan Li, Xinxin Zhao, Wenjing Zhang, Guannan Zhao, Zhongzhi Wu, Ruitao Zhang, Peixin Dong, Hidemichi Watari, Gabor Tigyi, Wei Li,Junming Yue
J. Cancer 2021; doi:10.7150/jca.61066; in press
[Author manuscript]

Overexpression Of TMEFF1 In Endometrial Carcinoma And The Mechanism Underlying Its Promotion Of Malignant Behavior In Cancer Cells
Xin Nie, Lingling Gao, Mingjun Zheng, Caixia Wang, Shuang Wang, Xiao Li, Yue Qi, Liancheng Zhu, Juanjuan Liu, Bei Lin
J. Cancer 2021; doi:10.7150/jca.58524; in press
[Author manuscript]

Disregulations of PURPL and MiR-338-3p Could Serve As Prognosis Biomarkers for Epithelial Ovarian Cancer
Ruitao zhang, Tingting He, Huirong Shi, Cao Yuan, Feng Wei, Zheying Liu, Wenwen Wang
J. Cancer 2021; doi:10.7150/jca.61327; in press
[Author manuscript]

Programmed Cell Death Protein 1/Programmed Cell Death Ligand-1 Axis Activates Intracellular ERK Signaling in Tumor Cells to Mediate Poor Prognosis in T-cell Lymphoma
Yang Li, Lu Liu, Yue Fei, Zheng Song, Xiangrui Meng, Lihua Qiu, Lanfang Li, Zhengzi Qian, Shiyong Zhou, Xiubao Ren, Chengfeng Bi, Bin Meng, Huilai Zhang, Xianhuo Wang, Kai Fu
J. Cancer 2021; doi:10.7150/jca.55971; accepted
[Author manuscript]

LncRNA-PVT1 indicates a poor prognosis and promotes angiogenesis via activating the HNF1B/EMT axis in glioma
Yongyan Bi, Jie Ji, Youxin Zhou
J. Cancer 2021; doi:10.7150/jca.60257; in press
[Author manuscript]

The Differential Antitumor Activity of 5-Aza-2'-deoxycytidine in Prostate Cancer DU145, 22RV1, and LNCaP Cells
Huiying Cheng, Xueqi Lian, Sijie Tang, Hong Meng, Jiajia Jiang, Xiaohua Li
J. Cancer 2021; doi:10.7150/jca.56709; in press
[Author manuscript]

HOTAIR promotes gefitinib resistance through modification of EZH2 and silencing p16 and p21 in non-small cell lung cancer
Weiting Li,Yongwen Li,Hongbing Zhang,Minghui Liu,Hao Gong,Yin Yuan,Ruifeng Shi,Zihe Zhang,Chao Liu,Chen Chen,Hongyu Liu,Jun Chen
J. Cancer 2021; doi:10.7150/jca.56093; in press
[Author manuscript]

lncRNA RP4-694A7.2 promotes hepatocellular carcinoma cell proliferation and metastasis through the regulation of PSAT1
Yaoxin Fan, Lin Wang, Yang Ding, Qiuju Sheng, Chong Zhang, Yanwei Li, Chao Han, Bingchao Lu, and Xiaoguang Dou
J. Cancer 2021; doi:10.7150/jca.59348; in press
[Author manuscript]

Muscle-Related Parameters as Determinants of Survival in Patients with Stage I-III Gastric Cancer Undergoing Gastrectomy
Soomin An, Wankyu Eo, and YounJung Kim
J. Cancer 2021; doi:10.7150/jca.61199; in press
[Author manuscript]

Treatment With Granulocyte-colony Stimulating Factor (G-CSF) Is Not Associated With Increased Risk Of Brain Metastasis In Patients With De Novo Stage IV Breast Cancer
Takeo Fujii, MD, MPH, Hasan Rehman, MD, Su Yun Chung, MD, Janice Shen, MD, James Newman, MD, Vernon Wu, MD, Adam Hines, MD, Elham Azimi-Nekoo, MD, Fayyaz, Fatima, MD, Meeyoung Lee, ANP, George Raptis, MD, Mikala Egeblad, PhD, Xinhua Zhu MD, PhD
J. Cancer 2021; doi:10.7150/jca.63159; in press
[Author manuscript]

CMTM3 Overexpression Predicts Poor Survival and Promotes Proliferation and Migration in Pancreatic Cancer
Zixuan Zhou, Zuyi Ma, Zhenchong Li, Hongkai Zhuang, Chunsheng Liu, Yuanfeng Gong, Shanzhou Huang, Chuanzhao Zhang, Baohua Hou
J. Cancer 2021; doi:10.7150/jca.57082; accepted
[Author manuscript]

miR-338-5p-ZEB2 axis in Diagnostic, Therapeutic Predictive and Prognostic Value of Gastric Cancer
Xiaoli Wei, Jiejie Zhu, Yiyin Zhang, Qihong Zhao, Hua Wang, Kangsheng Gu
J. Cancer 2021; doi:10.7150/jca.58249; accepted
[Author manuscript]

NEAT1/miR-101-dependent Up-regulation of DNA-PKcs Enhances Malignant Behaviors of Pancreatic Ductal Adenocarcinoma Cells
Hao Hu, Wuqiang Chen, Shuo Zhang, Yuzheng Xue, Youzhao He, Yuanlong Gu
J. Cancer 2021; doi:10.7150/jca.58824; in press
[Author manuscript]

Prediction Model of Lymph Node Metastasis Risk in Elderly Patients with Early Gastric Cancer before Endoscopic Resection: A Retrospective Analysis Based on International Multicenter Data
Siwei Pan, Wen An, Yuen Tan, Qingchuan Chen, Pengfei Liu, Huimian Xu
J. Cancer 2021; doi:10.7150/jca.56702; in press
[Author manuscript]

18F-FDG PET/CT metabolic parameters correlate with EIF2S2 expression status in colorectal cancer
Jian-Wei Yang, Ling-Ling Yuan, Yan Gao, Xu-Sheng Liu, Yu-Jiao Wang, Lu-Meng Zhou, Xue-Yan Kui, Xiao-Hui Li, Chang-Bin Ke, Zhi-Jun Pei
J. Cancer 2021; doi:10.7150/jca.57926; accepted
[Author manuscript]

A novel lncRNA-RPL34-AS1 promotes proliferation and angiogenesis in glioma by targeting VEGFA
Zhang Dongzhi,Jiang Haiping,Ye Junyi,Gao Ming,Wang Xinzhuang,Lu Enzhou,Yang He,Wang Lixiang,Zhao Shiguang
J. Cancer 2021; doi:10.7150/jca.59337; accepted
[Author manuscript]

Advances in deubiquitinating enzymes in lung adenocarcinoma
Xi-Jia Zhou, Rui Li, Xiao Liu, Yi-Qing Qu
J. Cancer 2021; doi:10.7150/jca.56532; in press
[Author manuscript]

The emergence of new prognostic scores in lung cancer patients with spinal metastasis: A 12-year single-center retrospective study
Qing Chen, Lei Zhou, Fancheng Chen, Xiaohui Chen, Annan Hu, Haifeng Liang, Libo Jiang, Xilei Li, Jian Dong
J. Cancer 2021; doi:10.7150/jca.60821; in press
[Author manuscript]

LncRNA-PANDAR regulates the progression of thyroid carcinoma by targeting miR-637/KLK4
Yi Qing, Qian Li, Ling-Yan Zhao, Ping ShiJin-Lu Shan, Wei Zhang
J. Cancer 2021; doi:10.7150/jca.55181; accepted
[Author manuscript]

Comparison of endoscopic injection of botulinum toxin and steroids immediately after endoscopic submucosal dissection to prevent esophageal stricture: a prospective cohort study
Xiaoying Zhou; Han Chen; Meihong Chen; Chao Ding; Guoxin Zhang; Xinmin Si
J. Cancer 2021; doi:10.7150/jca.60720; in press
[Author manuscript]

Suppression of aberrant activation of NF-κB pathway in drug-resistant leukemia stem cells contributes to Parthenolide-potentiated reversal of drug resistance in leukemia
Juan Yi, Li Wang, Xiao-Yan Wang, Jing-Sun, Xiao-Yang Yin, Jin-Xia Hou, Jing Chen, Bei Xie, Hu-Lai Wei
J. Cancer 2021; doi:10.7150/jca.52641; in press
[Author manuscript]

OxLDL as an inducer of a metabolic shift in cancer cells
Albert V. Bitorina, Yvonne Oligschlaeger, Lingling Ding, Tulasi Yadati, Annemarie Westheim, Tom Houben, Rianne D.W. Vaes, Steven W.M. Olde Damink, Jan Theys, Ronit Shiri-Sverdlov
J. Cancer 2021; doi:10.7150/jca.56307; accepted
[Author manuscript]

Dual Role of Reactive Oxygen Species and their Application in Cancer Therapy
Run Huang, Huan Chen, Jiayu Liang, Yi Li, Jiali Yang, Chuang Luo, Youshan Tang, Yu Ding, Xing Liu, Qing Yuan, Hong Yu, Yingchun Ye, Wenfeng Xu, Xiang Xie
J. Cancer 2021; doi:10.7150/jca.54699; in press
[Author manuscript]

A practical update on the epidemiology and risk factors for the emergence and mortality of bloodstream infections from real-world data of 3014 hematological malignancy patients receiving chemotherapy
Shaozhen Chen, Kangni Lin, Qian Li, Xiaofeng Luo, Min Xiao, Minmin Chen, Haojie Zhu, Yongquan Chen, Xueqiong Wu, Yanling Zeng, Yuxin Zhang, Issa Hajji Ally, Jingjing Xu, Jinhua Ren, Zhizhe Chen, Jianda Hu, and Ting Yang
J. Cancer 2021; doi:10.7150/jca.50802; in press
[Author manuscript]

Preoperative Versus Postoperative Transarterial Chemoembolization on Prognosis of Large Hepatocellular Carcinoma
Xiaohui Wang, Yu Yuan,Juncheng Wang, Zishan Liu, Qunfang Zhou, Minshan Chen, Zhongguo Zhou
J. Cancer 2021; doi:10.7150/jca.55806; accepted
[Author manuscript]

Safety and efficacy of fecal microbiota transplantation to treat and prevent recurrent Clostrioides difficile in cancer patients
Hiba Ali, MD, Shruti Khurana, MD, Weijie Ma, MD, Yuanzun Peng, Zhi-Dong Jiang, PhD, Herbert DuPont, MD, Hao Chi Zhang, MD, Anusha S. Thomas, MD, Pablo Okhuysen, MD, Yinghong Wang, MD, PhD
J. Cancer 2021; doi:10.7150/jca.59251; accepted
[Author manuscript]

Histone methyltransferase KMT2D regulated H3K4 methylation and was involved in the pathogenesis of ovarian cancer
Ming Li, Mengdie Shi, Ying Xu, Jianping Qiu, Qing Lv
J. Cancer 2021; doi:10.7150/jca.56753; accepted
[Author manuscript]

Inflammation Laboratory Parameters as Possible Prognostic Markers in Patients with Advanced-stage NSCLC Treated with Bevacizumab plus Chemotherapy
Martin Svaton, Jiri Blazek, Gabriela Krakorova, Marcela Buresova, Zuzana Teufelova, Josef Vodicka, Karolina Hurdalkova, Magda Barinova and Milos Pesek Department of Pneumology and Phthisiology, Charles University, Faculty of Medicine in Pilsen, Pilsen, Czech Republic Department of Surgery, Charles University, Faculty of Medicine in Pilsen, Pilsen, Czech Republic Institute of Biostatistics and Analyses, Ltd. Brno, Czech Republic
J. Cancer 2021; doi:10.7150/jca.58851; accepted
[Author manuscript]

Serum exosomal miR-34a as a potential biomarker for the diagnosis and prognostic of hepatocellular carcinoma
Shuying Chen, Yinqi Mao, Wei Chen, Chenbin Liu, Han Wu, Jingjun Zhang, Shenghao Wang, Chengpan Wang, Yong Lin, Yuan Lv
J. Cancer 2021; doi:10.7150/jca.57205; accepted
[Author manuscript]

The therapeutic effects of acupuncture and electroacupuncture on cancer-related symptoms and side-effects
Qiu-Qin Han, Yi Fu, Jia-Mei Le, Yu-Jie Ma, Xin-Dong Wei, Hou-Lin Ji, Haochen Jiang, Yueqiu Gao, Hailong Wu
J. Cancer 2021; doi:10.7150/jca.55803; accepted
[Author manuscript]

Diagnosis and prognostic value of C-X-C motif chemokine ligand 1 in colon adenocarcinoma based on The Cancer Genome Atlas and Guangxi cohort
Yi-Zhen Gong, Hui Ma, Guo-Tian Ruan, Li-Chen Zhu, Xi-Wen Liao, Shuai Wang, Ling Yan, Wei Huang, Ke-Tuan Huang, Hailun Xie, Guang-Zhi Zhu, Xiang-Kun Wang, Cun Liao, Feng Gao
J. Cancer 2021; doi:10.7150/jca.51524; in press
[Author manuscript]

PHLDA1 Modulates the Endoplasmic Reticulum Stress Response and is Required for Resistance to Oxidative Stress-induced Cell Death in Human Ovarian Cancer Cells
Jing Xu, Gang BiQingya Luo, Yi Liu, Tao Liu, Lanfang Li, Qi Zeng, Qien Wang, Yufeng Wang, Jianhua Yu, Ping Yi
J. Cancer 2021; doi:10.7150/jca.45262; in press
[Author manuscript]

The anti-osteosarcoma effect from panax notoginseng saponins by inhibiting the G0 / G1 phase in the cell cycle and affecting p53-mediated autophagy and mitochondrial apoptosis
Guangtao Han, MD, Yubiao Zhang, MD, Siqi Zhou, MD, Weisong Cai, MD, Ting Liu, MD, Haohuan Li, MD, Jianping Li, MD
J. Cancer 2021; doi:10.7150/jca.54602; accepted
[Author manuscript]

SLC25A21 suppresses cell growth in bladder cancer via the reactive oxygen species-mediated mitochondrion-dependent apoptosis pathway
Yong Wang, Jiawen Gao, Shasha Hu, Weiting Zeng, Hui Chen, Liankun Sun, Shuang Wang
J. Cancer 2021; doi:10.7150/jca.50906; accepted
[Author manuscript]

EVALUATION OF ANTI-CANCER FUNCTION OF TRANSGENIC HEMATOPOIETIC NATURAL KILLER CELLS
Alireza Pirahmadiana, Shaharudin Abdul Razak, Shamsul Azlin B Ahmad Shamsuddin
J. Cancer 2021; doi:10.7150/jca.48343; accepted
[Author manuscript]

Multimodality MRI-based Prediction Model for Histologic Grade of Hepatocellular Carcinoma
Baolin Wu, Fei Jia, Xuekun Li, Kaiyu Wang, Dongming Han, Zhiyun Jia
J. Cancer 2021; doi:10.7150/jca.49029; accepted
[Author manuscript]

The association between sites of distant metastases and overall survival in cervical cancer
Ce Wang, Zhenyi Xu, Jiali Song, Yuhong Lu, Meng Wang, Yan Hou
J. Cancer 2021; doi:10.7150/jca.41046; accepted
[Author manuscript]


Note: This page contains manuscripts that have been accepted by this journal. They haven't been copyedited by the journal and the content may change before final publication.