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J Cancer 2011; 2:413-424. doi:10.7150/jca.2.413 This volume Cite

Commentary

Malignant Transformation and Stromal Invasion from Normal or Hyperplastic Tissues: True or False?

Yan-gao Man¹, Michael Grinkemeyer², Mina Izadjoo¹, Alexander Stojadinovic^{3 ✉}

1. Diagnostic and Translational Research Center, Henry Jackson Foundation, Gaithersburg, MD, USA
2. Armed Forces Institute of Pathology, Washington DC, USA
3. Surgical Oncology, Walter-Reed Army Medical Center, Washington DC, USA

✉ Corresponding author: Yan-gao Man, MD., PhD., Diagnostic and Translational Research Center, Henry Jackson Foundation, 401 Professional Drive, Gaithersburg, 20879. Phone: 240-833-4969; Fax: 240-833-4940; E-mail: ymannorg

Abstract

Carcinogenesis is believed to be a multi-step process, progressing sequentially from normal to hyperplastic, to in situ, and to invasive stages. A number of studies, however, have detected malignancy-associated alterations in normal or hyperplastic tissues. As the molecular profile and clinical features of these tissues have not been defined, the authors invited several well-recognized pathologist, oncologists, biologist, surgeons, and molecular biologist to offer their opinion on: (1) whether these tissues belong to a previously unrevealed malignant entity or focal alterations with no significant consequence? (2) whether these alterations are linked to early onset of cancer or cancer of unknown primary site, and (3) how to further define these lesions?

Keywords: Malignant transformation, Tumor invasion, Sick lobe, Tumor microenvironment, Tumor capsule

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