J Cancer 2013; 4(8):653-661. doi:10.7150/jca.7626 This issue Cite

Review

Kisspeptin/KISS1R System in Breast Cancer

Donna Cvetković1, Andy V. Babwah 1,2,3,4, Moshmi Bhattacharya1, 3, 5✉

1. Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada, N6A 5C1;
2. The Children's Health Research Institute, London, Ontario, Canada;
3. Lawson Health Research Institute, London, Ontario, Canada;
4. Department of Obstetrics and Gynaecology, University of Western Ontario London, Ontario, Canada N6C 2V5;
5. Department of Oncology, University of Western Ontario, London, Ontario, Canada.

Citation:
Cvetković D, Babwah AV, Bhattacharya M. Kisspeptin/KISS1R System in Breast Cancer. J Cancer 2013; 4(8):653-661. doi:10.7150/jca.7626. https://www.jcancer.org/v04p0653.htm
Other styles

File import instruction

Abstract

Kisspeptins (KP), peptide products of the kisspeptin-1 (KISS1) gene are the endogenous ligands for a G protein-coupled receptor (GPCR) - KP receptor (KISS1R). KISS1R couples to the Gαq/11 signaling pathway. KISS1 is a metastasis suppressor gene and the KP/KISS1R signaling has anti-metastatic and tumor-suppressant effects in numerous human cancers. On the other hand, recent studies indicate that KP/KISS1R pathway plays detrimental roles in breast cancer. In this review, we summarize recent developments in the understanding of the mechanisms regulating KP/KISS1R signaling in breast cancer metastasis.

Keywords: Kisspeptin, KISS1R, breast cancer, metastasis, invasion, G protein-coupled receptor.


Citation styles

APA
Cvetković, D., Babwah, A.V., Bhattacharya, M. (2013). Kisspeptin/KISS1R System in Breast Cancer. Journal of Cancer, 4(8), 653-661. https://doi.org/10.7150/jca.7626.

ACS
Cvetković, D.; Babwah, A.V.; Bhattacharya, M. Kisspeptin/KISS1R System in Breast Cancer. J. Cancer 2013, 4 (8), 653-661. DOI: 10.7150/jca.7626.

NLM
Cvetković D, Babwah AV, Bhattacharya M. Kisspeptin/KISS1R System in Breast Cancer. J Cancer 2013; 4(8):653-661. doi:10.7150/jca.7626. https://www.jcancer.org/v04p0653.htm

CSE
Cvetković D, Babwah AV, Bhattacharya M. 2013. Kisspeptin/KISS1R System in Breast Cancer. J Cancer. 4(8):653-661.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
Popup Image