J Cancer
2016; 7(1):32-36.
doi:10.7150/jca.13292 This issueCite
Short Research Communication
Development of Soft Tissue Sarcomas in Ribosomal Proteins L5 and S24 Heterozygous Mice
Shideh Kazerounian1, 2✉, Pedro D.S.C. Ciarlini3, Daniel Yuan1, Roxanne Ghazvinian1, Meritxell Alberich-Jorda4, Mugdha Joshi1, 2, Hong Zhang2, 5, Alan H. Beggs1, 2, Hanna T. Gazda1, 2, 6✉
1. Boston Children's Hospital, Division of Genetics and Genomics, The Manton Center for Orphan Disease Research, Boston, MA, USA 2. Harvard Medical School, Boston, MA, USA 3. University Hospitals Case Medical Center, Cleveland, OH, USA 4. Institute of Molecular Genetics of the ASCR, Prague, Czech Republic 5. Beth Israel Deaconess Medical Center, Hematology/Oncology Division, Boston, MA, USA 6. Broad Institute, Cambridge, MA, USA
✉ Corresponding author: Shideh Kazerounian, Ph.D., Boston Children's Hospital, Harvard Medical School, Genetics/Genomics CLSB 15030.20, 3 Blackfan Circle, Boston, MA 02115. shideh.kazerounianharvard.edu; Phone: 617-355-7748; Fax: 617-730-0253 or Hanna T. Gazda, M.D., Ph.D., Boston Children's Hospital, Harvard Medical School, Genetics/Genomics CLSB 15023, 3 Blackfan Circle, Boston, MA 02115. hanna.gazdaharvard.edu; Phone: 617-919-4587; Fax: 617-730-0253More
Citation:
Kazerounian S, Ciarlini PDSC, Yuan D, Ghazvinian R, Alberich-Jorda M, Joshi M, Zhang H, Beggs AH, Gazda HT. Development of Soft Tissue Sarcomas in Ribosomal Proteins L5 and S24 Heterozygous Mice. J Cancer 2016; 7(1):32-36. doi:10.7150/jca.13292. https://www.jcancer.org/v07p0032.htm
Diamond-Blackfan anemia (DBA) is an inherited bone marrow failure syndrome associated with ribosomal protein (RP) gene mutations. Recent studies have also demonstrated an increased risk of cancer predisposition among DBA patients. In this study, we report the formation of soft tissue sarcoma in the Rpl5 and Rps24 heterozygous mice. Our observation suggests that even though one wild-type allele of the Rpl5 or Rps24 gene prevents anemia in these mice, it still predisposes them to cancer development.
Keywords: Ribosomal proteins RPL5 and RPS24, Diamond-Blackfan anemia, Soft tissue sarcoma, Rpl5 and Rps24 heterozygous mice
Citation styles
APA
Kazerounian, S., Ciarlini, P.D.S.C., Yuan, D., Ghazvinian, R., Alberich-Jorda, M., Joshi, M., Zhang, H., Beggs, A.H., Gazda, H.T. (2016). Development of Soft Tissue Sarcomas in Ribosomal Proteins L5 and S24 Heterozygous Mice. Journal of Cancer, 7(1), 32-36. https://doi.org/10.7150/jca.13292.
ACS
Kazerounian, S.; Ciarlini, P.D.S.C.; Yuan, D.; Ghazvinian, R.; Alberich-Jorda, M.; Joshi, M.; Zhang, H.; Beggs, A.H.; Gazda, H.T. Development of Soft Tissue Sarcomas in Ribosomal Proteins L5 and S24 Heterozygous Mice. J. Cancer 2016, 7 (1), 32-36. DOI: 10.7150/jca.13292.
NLM
Kazerounian S, Ciarlini PDSC, Yuan D, Ghazvinian R, Alberich-Jorda M, Joshi M, Zhang H, Beggs AH, Gazda HT. Development of Soft Tissue Sarcomas in Ribosomal Proteins L5 and S24 Heterozygous Mice. J Cancer 2016; 7(1):32-36. doi:10.7150/jca.13292. https://www.jcancer.org/v07p0032.htm
CSE
Kazerounian S, Ciarlini PDSC, Yuan D, Ghazvinian R, Alberich-Jorda M, Joshi M, Zhang H, Beggs AH, Gazda HT. 2016. Development of Soft Tissue Sarcomas in Ribosomal Proteins L5 and S24 Heterozygous Mice. J Cancer. 7(1):32-36.
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