J Cancer 2016; 7(3):289-296. doi:10.7150/jca.13432 This issue Cite

Research Paper

The Lymphocyte-Monocyte Ratio Predicts Patient Survival and Aggressiveness of Ovarian Cancer

Wan Kyu Eo1, Hye Jung Chang1, Sang Hoon Kwon2, Suk Bong Koh3, Young Ok Kim4, Yong Il Ji5, Hong-Bae Kim6, Ji Young Lee7, Dong Soo Suh8, Ki Hyung Kim8*✉, Ik Jin Chang9*✉, Heung Yeol Kim9, Suk Choo Chang10

1. Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea;
2. Department of Obstetrics and Gynecology, Keimyung University, School of Medicine, Daegu, Korea;
3. Department of Obstetrics and Gynecology, Catholic University of Daegu, School of Medicine, Daegu, Korea;
4. Department of Pathology, College of Medicine, Kosin University, Busan, Korea;
5. Department of Obstetrics and Gynecology, College of Medicine, Inje University, Busan, Korea;
6. Department of Obstetrics and Gynecology, Kangnam Sacred Heart Hospital, Hallym University Medical Center, Hallym University College of Medicine, Seoul, Korea;
7. Department of Obstetrics and Gynecology, Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Korea;
8. Department of Obstetrics and Gynecology, Pusan National University School of Medicine; Biomedical Research Institute, Pusan National University Hospital, Busan, Korea;
9. Department of Obstetrics and Gynecology, College of Medicine, Kosin University, Busan, Korea;
10. Department of Plastic and Reconstructive Surgery, College of Medicine, Kyung Hee University, Seoul, Korea.
*These authors equally contributed to this work.

Citation:
Eo WK, Chang HJ, Kwon SH, Koh SB, Kim YO, Ji YI, Kim HB, Lee JY, Suh DS, Kim KH, Chang IJ, Kim HY, Chang SC. The Lymphocyte-Monocyte Ratio Predicts Patient Survival and Aggressiveness of Ovarian Cancer. J Cancer 2016; 7(3):289-296. doi:10.7150/jca.13432. https://www.jcancer.org/v07p0289.htm
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Abstract

Objective: To measure the prognostic value of the lymphocyte-monocyte ratio (LMR) in patients with epithelial ovarian cancer (EOC).

Methods: We retrospectively examined the LMR as a prognosticator in a cohort of 234 patients with EOC who underwent surgical resection. Patients were categorized into two different groups based on the LMR (LMR-low and LMR-high) using cut-off values determined by receiver operating characteristic (ROC) curve analysis. The objective of the study was to assess the effect of the LMR on progression-free survival (PFS) and overall survival (OS), and to validate the LMR as an independent predictor of survival.

Results: Using the data collected from the whole cohort, the optimized LMR cut-off value selected on the ROC curve was 2.07 for both PFS and OS. The LMR-low and LMR-high groups included 48 (20.5%) and 186 patients (79.5%), respectively. The 5-year PFS rates in the LMR-low and LMR-high groups were 40.0 and 62.5% (P < 0.0001), respectively, and the 5-year OS rates in these two groups were 42.2 and 67.2% (P < 0.0001), respectively. On multivariate analysis, we identified age, International Federation of Gynecology and Obstetrics (FIGO) stage, and cancer antigen 125 levels to be the strongest valuable prognostic factors affecting PFS (P = 0.0421, P = 0.0012, and P = 0.0313, respectively) and age, FIGO stage, and the LMR as the most valuable prognostic factors predicting OS (P = 0.0064, P = 0.0029, and P = 0.0293, respectively).

Conclusion: The LMR is an independent prognostic factor affecting the survival of patients with EOC.

Keywords: Monocytes, Lymphocytes, Ovarian neoplasms


Citation styles

APA
Eo, W.K., Chang, H.J., Kwon, S.H., Koh, S.B., Kim, Y.O., Ji, Y.I., Kim, H.B., Lee, J.Y., Suh, D.S., Kim, K.H., Chang, I.J., Kim, H.Y., Chang, S.C. (2016). The Lymphocyte-Monocyte Ratio Predicts Patient Survival and Aggressiveness of Ovarian Cancer. Journal of Cancer, 7(3), 289-296. https://doi.org/10.7150/jca.13432.

ACS
Eo, W.K.; Chang, H.J.; Kwon, S.H.; Koh, S.B.; Kim, Y.O.; Ji, Y.I.; Kim, H.B.; Lee, J.Y.; Suh, D.S.; Kim, K.H.; Chang, I.J.; Kim, H.Y.; Chang, S.C. The Lymphocyte-Monocyte Ratio Predicts Patient Survival and Aggressiveness of Ovarian Cancer. J. Cancer 2016, 7 (3), 289-296. DOI: 10.7150/jca.13432.

NLM
Eo WK, Chang HJ, Kwon SH, Koh SB, Kim YO, Ji YI, Kim HB, Lee JY, Suh DS, Kim KH, Chang IJ, Kim HY, Chang SC. The Lymphocyte-Monocyte Ratio Predicts Patient Survival and Aggressiveness of Ovarian Cancer. J Cancer 2016; 7(3):289-296. doi:10.7150/jca.13432. https://www.jcancer.org/v07p0289.htm

CSE
Eo WK, Chang HJ, Kwon SH, Koh SB, Kim YO, Ji YI, Kim HB, Lee JY, Suh DS, Kim KH, Chang IJ, Kim HY, Chang SC. 2016. The Lymphocyte-Monocyte Ratio Predicts Patient Survival and Aggressiveness of Ovarian Cancer. J Cancer. 7(3):289-296.

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