J Cancer 2016; 7(4):364-366. doi:10.7150/jca.13593 This issue

Short Research Communication

Kinetics of Circulating Plasma Cell-Free DNA in Paediatric Classical Hodgkin Lymphoma

Simona Primerano1, Roberta Burnelli2, Elisa Carraro1, Marta Pillon1, Caterina Elia3, Piero Farruggia4, Alessandra Sala5, Luciana Vinti6, Salvatore Buffardi7, Giuseppe Basso1, Maurizio Mascarin3*, Lara Mussolin1,8*✉

1. Clinica di Oncoematologia Pediatrica, Dipartimento Salute della Donna e del Bambino, Azienda Ospedaliera-Universita' di Padova, Padova;
2. Unita' di Oncoematologia, Azienda Ospedaliero-Universitaria di Ferrara S.Anna, Ferrara;
3. SOS di Radioterapia Pediatrica CRO Aviano;
4. Dipartimento di Oncologia, Unita' di Oncoematologia Pediatrica, A.R.N.A.S. Ospedali Civico di Cristina e Benfratelli, Palermo;
5. Clinica Pediatrica, Università di Milano-Bicocca, Ospedale S.Gerardo, Fondazione Monza e Brianza per il Bambino e la sua Mamma, Monza;
6. Dipartimento di Oncoematologia Pediatrica, Ospedale Bambino Gesu', Roma;
7. Dipartimento di Oncologia Pediatrica, Ospedale Santobono-Pausillipon, Napoli;
8. Istituto di Ricerca Pediatrica-Fondazione Città della Speranza, Padova.
*co-last authors

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Primerano S, Burnelli R, Carraro E, Pillon M, Elia C, Farruggia P, Sala A, Vinti L, Buffardi S, Basso G, Mascarin M, Mussolin L. Kinetics of Circulating Plasma Cell-Free DNA in Paediatric Classical Hodgkin Lymphoma. J Cancer 2016; 7(4):364-366. doi:10.7150/jca.13593. Available from https://www.jcancer.org/v07p0364.htm

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Levels of plasma cell-free DNA (cfDNA) of a large series of children with classical Hodgkin lymphoma (cHL) were evaluated and analyzed at diagnosis and during chemotherapy treatment in relation with clinical characteristics. CfDNA levels in cHL patients were significantly higher compared with controls (p=0.002). CfDNA at diagnosis was correlated with presence of B symptoms (p=0.027) and high erythrocyte sedimentation rate (p=0.049). We found that the increasing of plasma cfDNA after first chemotherapy cycle seems to be associated with a worse prognosis (p=0.049). Levels of plasma cfDNA might constitute an interesting non-invasive tool in cHL patients' management.

Keywords: classical Hodgkin Lymphoma, cell-free DNA, childhood.