J Cancer 2016; 7(4):377-390. doi:10.7150/jca.13611 This issue


Drug Eluting Stents for Malignant Airway Obstruction: A Critical Review of the Literature

Wolfgang Hohenforst-Schmidt1, Paul Zarogoulidis2✉, Georgia Pitsiou2, Bernd Linsmeier3, Drosos Tsavlis2, Ioannis Kioumis2, Eleni Papadaki2, Lutz Freitag4, Theodora Tsiouda2, J Francis Turner5, Robert Browning6, Michael Simoff7, Nikolaos Sachpekidis8, Kosmas Tsakiridis8, Bojan Zaric9, Lonny Yarmus10, Sofia Baka11, Grigoris Stratakos12, Harald Rittger1

1. Medical Clinic I, ''Fuerth'' Hospital, University of Erlangen, Fuerth, Germany.
2. Pulmonary Department-Oncology Unit, ``G. Papanikolaou`` General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
3. Department of General Surgery, Coburg Clinic, Coburg, Germany.
4. Department of Interventional Pneumology, Ruhrlandklinik, University Hospital Essen, University of Essen-Duisburg, Tueschener Weg 40, 45239 Essen, Germany.
5. Division of Interventional Pulmonology & Medical Oncology, Cancer Treatment Centers of America, Western Regional Medical Center, Goodyear, AZ.
6. Pulmonary & Critical Care Medicine, Interventional Pulmonology, National Naval Medical Center, Walter Reed Army Medical Center, Bethesda, U.S.A.
7. Bronchoscopy and Interventional Pulmonology, Pulmonary and Critical Care Medicine, Henry Ford Hospital, Wayne State University, School of Medicine, MI, USA.
8. Cardiothoracic Surgery Department, ``Saint Luke`` Private Hospital, Thessaloniki, Panorama, Greece.
9. Institute for Pulmonary Diseases of Vojvodina, Clinic for Thoracic Oncology, Faculty of Medicine, University of Novi Sad, Serbia.
10. Division of Pulmonary and Critical Care Medicine, Sheikh Zayed Cardiovascular & Critical Care Tower, Baltimore, U.S.A.
11. Oncology Department, ``Interbalkan`` European Medical Center, Thessaloniki, Greece.
12. 1st Respiratory Medicine Department of National University of Athens, “Sotiria” General Hospital Athens, Greece.

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Hohenforst-Schmidt W, Zarogoulidis P, Pitsiou G, Linsmeier B, Tsavlis D, Kioumis I, Papadaki E, Freitag L, Tsiouda T, Turner JF, Browning R, Simoff M, Sachpekidis N, Tsakiridis K, Zaric B, Yarmus L, Baka S, Stratakos G, Rittger H. Drug Eluting Stents for Malignant Airway Obstruction: A Critical Review of the Literature. J Cancer 2016; 7(4):377-390. doi:10.7150/jca.13611. Available from https://www.jcancer.org/v07p0377.htm

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Lung cancer being the most prevalent malignancy in men and the 3rd most frequent in women is still associated with dismal prognosis due to advanced disease at the time of diagnosis. Novel targeted therapies are already on the market and several others are under investigation. However non-specific cytotoxic agents still remain the cornerstone of treatment for many patients. Central airways stenosis or obstruction may often complicate and decrease quality of life and survival of these patients. Interventional pulmonology modalities (mainly debulking and stent placement) can alleviate symptoms related to airways stenosis and improve the quality of life of patients. Mitomycin C and sirolimus have been observed to assist a successful stent placement by reducing granuloma tissue formation. Additionally, these drugs enhance the normal tissue ability against cancer cell infiltration. In this mini review we will concentrate on mitomycin C and sirolimus and their use in stent placement.

Keywords: pharmacology, stents.