ISSN: 1837-9664Journal of Cancer
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J Cancer 2016; 7(8):1002-1009. doi:10.7150/jca.14645 This issue Cite
Research Paper
Glypican-1 as a Biomarker for Prostate Cancer: Isolation and Characterization
Minomic International Ltd, Suite 2, Ground Floor, 75 Talavera Rd, Macquarie Park, NSW 2113, Australia
Citation:
Truong Q, Justiniano IO, Nocon AL, Soon JT, Wissmueller S, Campbell DH, Walsh BJ. Glypican-1 as a Biomarker for Prostate Cancer: Isolation and Characterization. J Cancer 2016; 7(8):1002-1009. doi:10.7150/jca.14645. https://www.jcancer.org/v07p1002.htm
Other stylesAbstract
Prostate cancer is the most frequently diagnosed male visceral cancer and the second leading cause of cancer death in the United States. Standard tests such as prostate-specific antigen (PSA) measurement have poor specificity (33%) resulting in a high number of false positive reports. Consequently there is a need for new biomarkers to address this problem. The MIL-38 antibody was first described nearly thirty years ago, however, until now, the identification of the target antigen remained elusive. By a series of molecular techniques and mass spectrometry, the MIL-38 antigen was identified to be the highly glycosylated proteoglycan Glypican-1 (GPC-1). This protein is present in two forms; a membrane bound core protein of 55-60 kDa and secreted soluble forms of 40 kDa and 52 kDa. GPC-1 identification was confirmed by immuno-precipitation, western blots and ELISA. An ELISA platform is currently being developed to assess the levels of GPC-1 in normal, benign prostatic hyperplasia (BPH) and prostate cancer patients to determine whether secreted GPC-1 may represent a clinically relevant biomarker for prostate cancer diagnosis.
Keywords: Prostate Cancer, Glypican 1, Proteoglycan, Theranostic
Citation styles
APA
Truong, Q., Justiniano, I.O., Nocon, A.L., Soon, J.T., Wissmueller, S., Campbell, D.H., Walsh, B.J. (2016). Glypican-1 as a Biomarker for Prostate Cancer: Isolation and Characterization. Journal of Cancer, 7(8), 1002-1009. https://doi.org/10.7150/jca.14645.
ACS
Truong, Q.; Justiniano, I.O.; Nocon, A.L.; Soon, J.T.; Wissmueller, S.; Campbell, D.H.; Walsh, B.J. Glypican-1 as a Biomarker for Prostate Cancer: Isolation and Characterization. J. Cancer 2016, 7 (8), 1002-1009. DOI: 10.7150/jca.14645.
NLM
Truong Q, Justiniano IO, Nocon AL, Soon JT, Wissmueller S, Campbell DH, Walsh BJ. Glypican-1 as a Biomarker for Prostate Cancer: Isolation and Characterization. J Cancer 2016; 7(8):1002-1009. doi:10.7150/jca.14645. https://www.jcancer.org/v07p1002.htm
CSE
Truong Q, Justiniano IO, Nocon AL, Soon JT, Wissmueller S, Campbell DH, Walsh BJ. 2016. Glypican-1 as a Biomarker for Prostate Cancer: Isolation and Characterization. J Cancer. 7(8):1002-1009.
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