J Cancer 2016; 7(9):1037-1043. doi:10.7150/jca.14971 This issue

Research Paper

Prevalence and Genotype Distribution of HPV Infection in China: Analysis of 51,345 HPV Genotyping Results from China's Largest CAP Certified Laboratory

Zhengyu Zeng*1, Huaitao Yang*2, Zaibo Li3, Xuekui He1, Christopher C. Griffith4, Xiamen Chen1, Xiaolei Guo1, Baowen Zheng1, Shangwei Wu1, Chengquan Zhao5✉

1. Guangzhou Kingmed Diagnostics, Guangzhou, Guangdong 510330, P. R. China.
2. Department of Pathology, University Cincinnati College of Medicine, Cincinnati, OH 45219, USA.
3. Department of Pathology, Wexner Medical Center at Ohio State University, Columbus, OH 43210, USA.
4. Department of Pathology, Emory University, Atlanta, GA, 30342, USA.
5. Department of Pathology, Magee-Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
* Both authors made equal contribution for this paper.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
Zeng Z, Yang H, Li Z, He X, Griffith CC, Chen X, Guo X, Zheng B, Wu S, Zhao C. Prevalence and Genotype Distribution of HPV Infection in China: Analysis of 51,345 HPV Genotyping Results from China's Largest CAP Certified Laboratory. J Cancer 2016; 7(9):1037-1043. doi:10.7150/jca.14971. Available from https://www.jcancer.org/v07p1037.htm

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Introduction: The prevalence of cervical Human Papillomavirus (HPV) infection varies greatly worldwide and data regarding HPV prevalence and genotypes in China are limited.

Methods: HPV testing results were retrospectively examined at KingMed Diagnostics, the largest independent pathology laboratory in China, from January 2011 to June 2014. All testing was performed using the 26 HPV Genotyping Panel of TellgenplexTM xMAP™ HPV DNA Test assay (TELLGEN, Shanghai, China). Overall prevalence, age-specific prevalence and genotype distributions were analyzed.

Results: A total of 51,345 samples were tested and the overall HPV prevalence was 26%, with 21.12% positive for high risk (HR) HPV and 8.37% positive for low risk HPV. 80% of HPV positive cases were positive for a single HPV type. The three most common HR HPV types detected were HPV-52, -16, and -58, in descending order. HPV-18 was only the 6th most common type. When women were divided into three age groups: <30, 30-49, ≥50 years, HR HPV had the highest prevalence rate in women <30 years, and the lowest rate in women 30-49 years of age. The distribution of HR HPV genotypes also varied among these three age groups.

Conclusions: To the best of our knowledge, this is largest routine clinical practice report of HPV prevalence and genotypes in a population of women having limited cervical cancer screening. HPV-52 was the most prevalent HR HPV type in this population of women followed by HPV-16 and HPV-58. The overall and age-specific prevalence and genotype distribution of HR HPV are different in this Chinese population compared to that reported from Western countries.

Keywords: cervical cancer, HPV, genotyping, prevalence, China