Class I versus Class III radical hysterectomy in stage IB1 (tumor ≤ 2 cm) cervical cancer: a matched cohort study

Wang, Wei; Shang, Chun-liang; Du, Qi-qiao; Wu, Di; Liang, Yan-chun; Liu, Tian-yu; Huang, Jia-ming; Yao, Shu-zhong

doi:10.7150/jca.17663

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J Cancer 2017; 8(5):825-831. doi:10.7150/jca.17663 This issue Cite

Research Paper

Class I versus Class III radical hysterectomy in stage IB1 (tumor ≤ 2 cm) cervical cancer: a matched cohort study

Wei Wang^*, Chun-liang Shang^*, Qi-qiao Du, Di Wu, Yan-chun Liang, Tian-yu Liu, Jia-ming Huang, Shu-zhong Yao^✉

Department of Obstetrics and Gynecology, the First Affiliated Hospital, Sun Yat-sen University, Zhongshan Second Road 58, Guangzhou 510700, China.
* These authors contributed equally to this article.

Citation:

Wang W, Shang Cl, Du Qq, Wu D, Liang Yc, Liu Ty, Huang Jm, Yao Sz. Class I versus Class III radical hysterectomy in stage IB1 (tumor ≤ 2 cm) cervical cancer: a matched cohort study. J Cancer 2017; 8(5):825-831. doi:10.7150/jca.17663. https://www.jcancer.org/v08p0825.htm

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Abstract

Background & Aims: The long-term oncological outcome of Class I hysterectomy to treat stage IB1 cervical cancer is unclear. The aim of the present study was to compare the surgical and long-term oncological outcomes of Class I hysterectomy and Class III radical hysterectomy for treatment of stage IB1 cervical cancer (tumor ≤ 2 cm).

Methods: Seventy stage IB1 cervical cancer patients (tumor ≤ 2 cm) underwent Class I hysterectomy and 577 stage IB1 cervical cancer patients (tumor ≤ 2 cm) underwent Class III radical hysterectomy were matched with known risk factors for recurrence by greedy algorithm. Clinical, pathologic and follow-up data were retrospectively collected. Five-year survival outcomes were assessed using Kaplan-Meier model.

Results: After matching, a total of 70 patient pairs (Class I - Class III) were included. The median follow-up times were 75 (range, 26-170) months in the Class III group and 75 (range, 27-168) months in the Class I group. The Class I and Class III group had similar 5-year recurrence-free survival rates (RFS) (98.6% vs. 97.1%, P = 0.56) and overall survival rates (OS) (100.0% vs. 98.5%, P = 0.32). Compared with the Class III group, the Class I group resulted in significantly shorter operating time, less intra-operative blood loss, less intraoperative complications, less postoperative complications, and shorter hospital stay.

Conclusions: These findings suggest that Class I hysterectomy is an oncological safe alternative to Class III radical hysterectomy in treatment of stage IB1 cervical cancer (tumor ≤ 2 cm) and Class I hysterectomy is associated with fewer perioperative complication and earlier recovery.

Keywords: Cervical cancer, Oncological outcomes, Surgical outcomes, Class I hysterectomy, Class III radical hysterectomy.

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APA

Wang, W., Shang, C.l., Du, Q.q., Wu, D., Liang, Y.c., Liu, T.y., Huang, J.m., Yao, S.z. (2017). Class I versus Class III radical hysterectomy in stage IB1 (tumor ≤ 2 cm) cervical cancer: a matched cohort study. Journal of Cancer, 8(5), 825-831. https://doi.org/10.7150/jca.17663.

ACS

Wang, W.; Shang, C.l.; Du, Q.q.; Wu, D.; Liang, Y.c.; Liu, T.y.; Huang, J.m.; Yao, S.z. Class I versus Class III radical hysterectomy in stage IB1 (tumor ≤ 2 cm) cervical cancer: a matched cohort study. J. Cancer 2017, 8 (5), 825-831. DOI: 10.7150/jca.17663.

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CSE

Wang W, Shang Cl, Du Qq, Wu D, Liang Yc, Liu Ty, Huang Jm, Yao Sz. 2017. Class I versus Class III radical hysterectomy in stage IB1 (tumor ≤ 2 cm) cervical cancer: a matched cohort study. J Cancer. 8(5):825-831.

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