A novel blood tool of cancer prognosis in esophageal squamous cell carcinoma: the Fibrinogen/Albumin Ratio

Tan, Zihui; Zhang, Man; Han, Qiang; Wen, Jing; Luo, Kongjia; Lin, Peng; Zhang, Lanjun; Yang, Hong; Fu, Jianhua

doi:10.7150/jca.16491



International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

Nanotheranostics

Global reach, higher impact

Full Text | PDF

J Cancer 2017; 8(6):1025-1029. doi:10.7150/jca.16491 This issue Cite

Research Paper

A novel blood tool of cancer prognosis in esophageal squamous cell carcinoma: the Fibrinogen/Albumin Ratio

Zihui Tan^1,2,3*, Man Zhang^4*, Qiang Han^5*, Jing Wen^1,2,3, Kongjia Luo^1,2,3, Peng Lin^1,2,3, Lanjun Zhang^1,2,3, Hong Yang^1,2,3, Jianhua Fu^1,2,3✉

1. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine.
2. Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, China.
3. Guangdong Esophageal Cancer Institute, Guangzhou, China.
4. Department of Ultrasound, The third affiliated hospital, SunYat-senUniversity,600 Tianhe Road, Guangzhou, China.
5. Department of Thoracic Surgery, The fifth affiliated hospital, SunYat-senUniversity, Zhuhai, China.
* These authors contributed equally to this work

Citation:

Tan Z, Zhang M, Han Q, Wen J, Luo K, Lin P, Zhang L, Yang H, Fu J. A novel blood tool of cancer prognosis in esophageal squamous cell carcinoma: the Fibrinogen/Albumin Ratio. J Cancer 2017; 8(6):1025-1029. doi:10.7150/jca.16491. https://www.jcancer.org/v08p1025.htm

Other styles

Abstract

Background: Coagulation and nutrition play important roles in cancer progression. We aim to investigate the impact of the fibrinogen/albumin ratio(FAR) in esophageal squamous cell carcinoma (ESCC) patients.

Methods: We retrospectively analyzed 1135 patients with radical esophagectomy for ESCC from January 2008 to December 2010 in our center. X-tile software was used to determine the optimal cutoff levels for these biomarkers.

Results: The optimal cutoff value was 0.08 for the FAR by the X-tile software. The FAR was statistically significantly associated with age(p=0.003), sex(p=0.030), tumor length (p=0.043), pT status(p<0.001) and pN status(p<0.001). Pearson's correlation indicated that the FAR were positively associated with the serum C-reactive protein (CRP) ( r=0.583, p<0.001), and the NLR ( r=0.316, p<0.001). Multivariate analysis indicated that age, tumor grade, pT status, pN status and preoperative FAR were independent prognostic factors in patients with ESCC.

Conclusions: Preoperative FAR was an independent prognostic factor in ESCC patients. Lower FAR may improve OS of ESCC patients.

Keywords: esophageal squamous cell carcinoma, blood tool, fibrinogen, albumin

Citation styles

APA

Tan, Z., Zhang, M., Han, Q., Wen, J., Luo, K., Lin, P., Zhang, L., Yang, H., Fu, J. (2017). A novel blood tool of cancer prognosis in esophageal squamous cell carcinoma: the Fibrinogen/Albumin Ratio. Journal of Cancer, 8(6), 1025-1029. https://doi.org/10.7150/jca.16491.

ACS

Tan, Z.; Zhang, M.; Han, Q.; Wen, J.; Luo, K.; Lin, P.; Zhang, L.; Yang, H.; Fu, J. A novel blood tool of cancer prognosis in esophageal squamous cell carcinoma: the Fibrinogen/Albumin Ratio. J. Cancer 2017, 8 (6), 1025-1029. DOI: 10.7150/jca.16491.

NLM

CSE

Tan Z, Zhang M, Han Q, Wen J, Luo K, Lin P, Zhang L, Yang H, Fu J. 2017. A novel blood tool of cancer prognosis in esophageal squamous cell carcinoma: the Fibrinogen/Albumin Ratio. J Cancer. 8(6):1025-1029.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.