1. Department of Nephrology & Rheumatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China;
2. Department of gastroenterology, Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China;
3. Department of Developmental Genetics, Nanjing Medical University, Nanjing 211166, China;
4. Department of Oncology, Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China;
5. Nanjing Red Cross Blood Center, Nanjing 210003, China.
* Ying Luo, Sihong You and Jirong Wang contributed equally to this study and share first authorship.
Purpose: Sumoylation plays a critical role in gene regulation and tumorigenesis, and is hypothesized to correlate with the development of various cancers. So far, there has been no reported association between sumoylation-related genes and the risk of gastric cancer (GC).
Methods: A total of 17 tagging single-nucleotide polymorphisms (tag-SNPs) in 5 sumoylation-related genes were selected and genotyped by SNaPshot in a case-control study, including 1021 GC patients and 1304 controls. Odds ratio (OR) and 95% confidential interval (CI) were computed to evaluate the genetic association of the onset of GC.
Results: We demonstrated that CBX4 rs77447679 polymorphism was significantly associated with GC risk (P= 0.017; adjusted OR: 1.71; 95% CI: 1.10-2.66). The patients with CC genotype had a lower risk of GC (CC vs. CA+AA, P= 0.017; adjusted OR: 1.24; 95% CI: 1.04-1.49).
Conclusion: This study revealed that CBX4 rs77447679 polymorphism was positively associated with GC, and individuals with CC genotype had less risk of GC. The risky effects and functional effect of this polymorphism in GC require further investigation.
Keywords: sumoylation, haploview, polymorphism, gastric cancer, susceptibility.