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J Cancer 2017; 8(16):3268-3273. doi:10.7150/jca.21555 This issue Cite

Research Paper

Fluid intake-to-bed time, nocturia frequency and the risk of urothelial carcinoma of the bladder: a case-control study

Jianfeng Cui1, Qiyu Bo2, Ning Zhang1, Shouzhen Chen1, Meng Yu1, Shiyu Wang1, Jie Han3, Pengxiang Chen4, Dongqing Zhang1, Yaofeng Zhu1✉, Benkang Shi1✉

1. Department of Urology, Qilu Hospital of Shandong University, Jinan, 250012 P.R. China;
2. Department of First Operating Room, Qilu Hospital of Shandong University, Jinan, 250012 P.R. China;
3. Department of Radiation Oncology, Shandong Cancer Hospital and Institute affiliated to Shandong University, Jinan, P.R. China;
4. Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, 250012 P.R. China.

✉ Corresponding authors: Benkang Shi and Yaofeng Zhu; E-mail: bkang68edu.cn, yaofengzhu2016com; Fax: +86-531-86927544; Tel: +86-18769780320

Citation:
Cui J, Bo Q, Zhang N, Chen S, Yu M, Wang S, Han J, Chen P, Zhang D, Zhu Y, Shi B. Fluid intake-to-bed time, nocturia frequency and the risk of urothelial carcinoma of the bladder: a case-control study. J Cancer 2017; 8(16):3268-3273. doi:10.7150/jca.21555. https://www.jcancer.org/v08p3268.htm
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Abstract

Objectives: To clarify the potential role of fluid intake-to-bed time and nocturia frequency on bladder cancer risk in a hospital-based case-control study with Chinese people.

Materials and Methods: Four hundred and seven patients with histologically diagnosed bladder cancer and 400 matched controls were enrolled in this study. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression model.

Results: After adjustment for potential confounders, the fluid intake-to-bed time was associated with a decreased risk of BCa, with an OR of 0.586 (95% CI= 0.375-0.916, ≤1h) and 0.257 (95% CI= 0.162-0.407, >1h). The adjusted OR of BCa for subjects with more nocturia frequency (≥2 times) was 2.268 (95 % CI= 1.481-3474), compared to those with no nocturia.

Conclusion: We suggested strong protective effect of long fluid intake-to-bed time on BCa risk, especially in ones with ≥2 times nocturia frequency. These results provide evidence for identifying high-risk individuals and modifying their behaviors and lifestyle.

Keywords: bladder cancer, case-control study, fluid intake-to-bed time, nocturia

Citation styles

APA
Cui, J., Bo, Q., Zhang, N., Chen, S., Yu, M., Wang, S., Han, J., Chen, P., Zhang, D., Zhu, Y., Shi, B. (2017). Fluid intake-to-bed time, nocturia frequency and the risk of urothelial carcinoma of the bladder: a case-control study. Journal of Cancer, 8(16), 3268-3273. https://doi.org/10.7150/jca.21555.

ACS
Cui, J.; Bo, Q.; Zhang, N.; Chen, S.; Yu, M.; Wang, S.; Han, J.; Chen, P.; Zhang, D.; Zhu, Y.; Shi, B. Fluid intake-to-bed time, nocturia frequency and the risk of urothelial carcinoma of the bladder: a case-control study. J. Cancer 2017, 8 (16), 3268-3273. DOI: 10.7150/jca.21555.

NLM
Cui J, Bo Q, Zhang N, Chen S, Yu M, Wang S, Han J, Chen P, Zhang D, Zhu Y, Shi B. Fluid intake-to-bed time, nocturia frequency and the risk of urothelial carcinoma of the bladder: a case-control study. J Cancer 2017; 8(16):3268-3273. doi:10.7150/jca.21555. https://www.jcancer.org/v08p3268.htm

CSE
Cui J, Bo Q, Zhang N, Chen S, Yu M, Wang S, Han J, Chen P, Zhang D, Zhu Y, Shi B. 2017. Fluid intake-to-bed time, nocturia frequency and the risk of urothelial carcinoma of the bladder: a case-control study. J Cancer. 8(16):3268-3273.

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