J Cancer 2017; 8(16):3268-3273. doi:10.7150/jca.21555 This issue
1. Department of Urology, Qilu Hospital of Shandong University, Jinan, 250012 P.R. China;
2. Department of First Operating Room, Qilu Hospital of Shandong University, Jinan, 250012 P.R. China;
3. Department of Radiation Oncology, Shandong Cancer Hospital and Institute affiliated to Shandong University, Jinan, P.R. China;
4. Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, 250012 P.R. China.
Objectives: To clarify the potential role of fluid intake-to-bed time and nocturia frequency on bladder cancer risk in a hospital-based case-control study with Chinese people.
Materials and Methods: Four hundred and seven patients with histologically diagnosed bladder cancer and 400 matched controls were enrolled in this study. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression model.
Results: After adjustment for potential confounders, the fluid intake-to-bed time was associated with a decreased risk of BCa, with an OR of 0.586 (95% CI= 0.375-0.916, ≤1h) and 0.257 (95% CI= 0.162-0.407, >1h). The adjusted OR of BCa for subjects with more nocturia frequency (≥2 times) was 2.268 (95 % CI= 1.481-3474), compared to those with no nocturia.
Conclusion: We suggested strong protective effect of long fluid intake-to-bed time on BCa risk, especially in ones with ≥2 times nocturia frequency. These results provide evidence for identifying high-risk individuals and modifying their behaviors and lifestyle.
Keywords: bladder cancer, case-control study, fluid intake-to-bed time, nocturia