A Bottleneck in Understanding Metastatic Cancer Stem Cell of Peritoneal Seeding from Gastric Cancer: A Null Result in Brief

Xin-Zu Chen¹, Xiao-Hai Song^1*, Xiao-Long Chen^1*, Chang-Chun Li¹, Xian-Ming Mo², Jian-Kun Hu^1✉

1. Department of Gastrointestinal Surgery and Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China;
2. Laboratory of Stem Cell Biology, West China Hospital, Sichuan University, Chengdu, China.
*Xiao-Hai Song and Xiao-Long Chen contributed equally in this work as co-first authors.

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Citation:
Chen XZ, Song XH, Chen XL, Li CC, Mo XM, Hu JK. A Bottleneck in Understanding Metastatic Cancer Stem Cell of Peritoneal Seeding from Gastric Cancer: A Null Result in Brief. J Cancer 2017; 8(16):3274-3277. doi:10.7150/jca.21669. Available from https://www.jcancer.org/v08p3274.htm

Abstract

The capture of peritoneal metastatic cancer stem cell of human gastric cancer (pMCSC-hGC) is important to further understand the mechanism of peritoneal metastasis in gastric cancer patients. Previously, cancer stem cells (CSCs) of gastric and rectal cancers were captured and identified. However, the bottleneck of capturing pMCSC-hGC may be the scarce surgical specimen and limited volume of peritoneal metastatic lesions from gastric cancer. Only 5.2% of patients were diagnosed of unpredictive peritoneal seeding intraoperatively, while none cell sphere were successfully formed through the identical culture approach based on peritoneal metastatic nodules. The attempt to enrich and capture pMCSC of transplanted gastric cancer (pMCSC-tGC) in immunodeficiency mice model through intraperitoneal injection of CSC-hGC may be a considerable and feasible alteration.

Keywords: gastric cancer, peritoneal metastasis, cancer stem cell, clonal heterogeneity, null result