Multiple guided technologies based on radial probe endobronchial ultrasound for the diagnosis of solitary peripheral pulmonary lesions: a single-center study

Haidong, Huang; Yunye, Ning; Wei, Zhang; Zarogoulidis, Paul; Hohenforst-Schmidt, Wolfgang; Man, Yan-Gao; Yuguang, Yang; Yuchao, Dong; Chong, Bai

doi:10.7150/jca.20035

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J Cancer 2017; 8(17):3514-3521. doi:10.7150/jca.20035 This issue Cite

Research Paper

Multiple guided technologies based on radial probe endobronchial ultrasound for the diagnosis of solitary peripheral pulmonary lesions: a single-center study

Huang Haidong^1*, Ning Yunye^1*, Zhang Wei^1*, Paul Zarogoulidis^2✉, Wolfgang Hohenforst-Schmidt³, Yan-Gao Man⁴, Yang Yuguang⁵, Dong Yuchao¹, Bai Chong^1✉

1. Department of Respiratory and Critical Care Medicine, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China.
2. Pulmonary Department-Oncology Unit, “Theageneio“ Anticancer Hospital, Thessaloniki, Greece.
3. Sana Clinic Group Franken, Department of Cardiology / Pulmonology / Intensive Care / Nephrology, ''Hof'' Clinics, University of Erlangen, Hof, Germany.
4. International Union for Difficult-to-treat-Diseases (IUDD), MD, USA.
5. Department of anesthesiologist, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China.
* Huang Haidong, Ning Yunye, Zhang Wei contributed equally to this work.

Citation:

Haidong H, Yunye N, Wei Z, Zarogoulidis P, Hohenforst-Schmidt W, Man YG, Yuguang Y, Yuchao D, Chong B. Multiple guided technologies based on radial probe endobronchial ultrasound for the diagnosis of solitary peripheral pulmonary lesions: a single-center study. J Cancer 2017; 8(17):3514-3521. doi:10.7150/jca.20035. https://www.jcancer.org/v08p3514.htm

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Abstract

Objective To evaluate the value of multiple guided technologies based on radial probe endobronchial ultrasound (R-EBUS) in the application of the diagnosis of solitary pulmonary peripheral lesions (PPLs).

Methods Analysis of diagnostic yield in 4 groups patients with different combined multiple guided technologies based on R-EBUS, 94 patients with 94 solitary PPLs from Mar, 2013 to Nov, 2014 in Changhai Hospital.

Results The overall diagnostic yield was 75% (70/94), the diagnostic yield of Group A (R-EBUS) was 62%(16/26), Group B (R-EBUS with guided sheath, EBUS-GS) was 76% (34/45), Group C (EBUS-GS with fluoroscopy) was 82% (9/11), Group D (virtual bronchoscopic navigation guided EBUS-GS with fluoroscopy) was 92% (11/12). The overall histopathological diagnostic yield was 56% (53/94. Better histopathological diagnostic yield was associated with application of multiple guided technologies based on EBUS-GS, lesions located in non-lower lobes, lesion's diameter > 2cm, radial probe within the lesions and lidocaine nebulization combined with intravenous anesthesia. There were no severe complications in all the 94 cases. A ultrasonic radial probe was broken when exploring a lesion located in the apical-posterior segment of left upper lobe.

Conclusion Multiple guided technologies based on R-EBUS were safe and effective in the diagnosis of solitary PPLs. In practice, the diagnosis yield improved with the application of forcep biopsies combined with bronchial brushing and washing.

Keywords: bronchoscope, endobronchial ultrasound, radial probe, virtual bronchial navigation (VBN), EBUS-GS, fluoroscopy, peripheral pulmonary lesion, biopsy, diagnosis

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APA

Haidong, H., Yunye, N., Wei, Z., Zarogoulidis, P., Hohenforst-Schmidt, W., Man, Y.G., Yuguang, Y., Yuchao, D., Chong, B. (2017). Multiple guided technologies based on radial probe endobronchial ultrasound for the diagnosis of solitary peripheral pulmonary lesions: a single-center study. Journal of Cancer, 8(17), 3514-3521. https://doi.org/10.7150/jca.20035.

ACS

Haidong, H.; Yunye, N.; Wei, Z.; Zarogoulidis, P.; Hohenforst-Schmidt, W.; Man, Y.G.; Yuguang, Y.; Yuchao, D.; Chong, B. Multiple guided technologies based on radial probe endobronchial ultrasound for the diagnosis of solitary peripheral pulmonary lesions: a single-center study. J. Cancer 2017, 8 (17), 3514-3521. DOI: 10.7150/jca.20035.

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CSE

Haidong H, Yunye N, Wei Z, Zarogoulidis P, Hohenforst-Schmidt W, Man YG, Yuguang Y, Yuchao D, Chong B. 2017. Multiple guided technologies based on radial probe endobronchial ultrasound for the diagnosis of solitary peripheral pulmonary lesions: a single-center study. J Cancer. 8(17):3514-3521.

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