J Cancer 2017; 8(19):3984-3991. doi:10.7150/jca.20971 This issue Cite

Research Paper

Post-Resection Exhaustion of Intra-Platelet Serotonin: Also an Indicator of Early Hepatocellular Carcinoma Recurrence?

Bibek Aryal1, Toshiaki Shimizu2, Jun Kadono1, Akira Furoi3, Teruo Komokata4, Iwao Kitazono1, Chihaya Koriyama5, Munekazu Yamakuchi2, Teruto Hashiguchi2*✉, Yutaka Imoto1*

1. Cardiovascular and Gastroenterological Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University 890-8520, Kagoshima, Japan
2. Department of Laboratory and Vascular Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8520, Japan
3. Department of Surgery, Kirishima Medical Center, Kirishima 899-5112, Japan.
4. Department of Surgery, Kagoshima Medical Center, National Hospital Organization, Kagoshima 892-0853, Japan
5. Department of Epidemiology and Preventive Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8520, Japan
* These authors share joint senior authorship

Citation:
Aryal B, Shimizu T, Kadono J, Furoi A, Komokata T, Kitazono I, Koriyama C, Yamakuchi M, Hashiguchi T, Imoto Y. Post-Resection Exhaustion of Intra-Platelet Serotonin: Also an Indicator of Early Hepatocellular Carcinoma Recurrence?. J Cancer 2017; 8(19):3984-3991. doi:10.7150/jca.20971. https://www.jcancer.org/v08p3984.htm
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Abstract

Purpose: Serotonin (5-hydroxytryptamine, 5-HT) is well known for its growth stimulatory effect on several types of carcinoma and tumor cells. Since a large portion of 5-HT is stored and transported by platelets, the aim of this study was to assess the influence of platelet-sequestered 5-HT on post-resection hepatocellular carcinoma (HCC) recurrence.

Methods: This pilot study was conducted in a cohort of forty patients diagnosed with HCC undergoing partial hepatectomy. 5-HT levels in serum, plasma and intra-platelet (IP) were monitored preoperatively and four weeks after liver resection. The patients were followed every three months after the surgery.

Results: Follow-up was standardized to a fixed length of time. Fifteen patients (37.5%) developed HCC recurrence during 18 months follow-up. Patients with recurrence had significantly reduced serum and IP 5-HT levels at four weeks of liver resection (P = 0.003 and P = 0.014 respectively). Accordingly, in the Cox regression hazard model, serum and IP 5-HT were able to independently predict the recurrence (hazard ratio = 0.1, 95% confidence interval = 0.01 - 0.75 and hazard ratio = 0.1, 95% confidence interval = 0.01 - 0.89 respectively). The optimal cut-off value of 42.77 ng/ml for serum [area under the curve (AUC): 0.78, P = 0.003] and 0.3117 ng per 106 platelets (AUC: 0.733, P = 0.015), on receiver operating characteristic (ROC) curve corresponded to maximum sensitivity and specificity of prediction. The disease free interval was significantly worse in patients with low serum and IP 5-HT (P = 0.001 and P = 0.029 respectively).

Conclusion: IP 5-HT monitored during early follow-up, after liver resection may represent a useful marker of early HCC recurrence.

Keywords: Hepatocellular Carcinoma, liver cirrhosis, liver resection, platelet, serotonin


Citation styles

APA
Aryal, B., Shimizu, T., Kadono, J., Furoi, A., Komokata, T., Kitazono, I., Koriyama, C., Yamakuchi, M., Hashiguchi, T., Imoto, Y. (2017). Post-Resection Exhaustion of Intra-Platelet Serotonin: Also an Indicator of Early Hepatocellular Carcinoma Recurrence?. Journal of Cancer, 8(19), 3984-3991. https://doi.org/10.7150/jca.20971.

ACS
Aryal, B.; Shimizu, T.; Kadono, J.; Furoi, A.; Komokata, T.; Kitazono, I.; Koriyama, C.; Yamakuchi, M.; Hashiguchi, T.; Imoto, Y. Post-Resection Exhaustion of Intra-Platelet Serotonin: Also an Indicator of Early Hepatocellular Carcinoma Recurrence?. J. Cancer 2017, 8 (19), 3984-3991. DOI: 10.7150/jca.20971.

NLM
Aryal B, Shimizu T, Kadono J, Furoi A, Komokata T, Kitazono I, Koriyama C, Yamakuchi M, Hashiguchi T, Imoto Y. Post-Resection Exhaustion of Intra-Platelet Serotonin: Also an Indicator of Early Hepatocellular Carcinoma Recurrence?. J Cancer 2017; 8(19):3984-3991. doi:10.7150/jca.20971. https://www.jcancer.org/v08p3984.htm

CSE
Aryal B, Shimizu T, Kadono J, Furoi A, Komokata T, Kitazono I, Koriyama C, Yamakuchi M, Hashiguchi T, Imoto Y. 2017. Post-Resection Exhaustion of Intra-Platelet Serotonin: Also an Indicator of Early Hepatocellular Carcinoma Recurrence?. J Cancer. 8(19):3984-3991.

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