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J Cancer 2018; 9(8):1437-1447. doi:10.7150/jca.23969 This issue Cite

Research Report

International Consensus on the Clinical Management of Inflammatory Breast Cancer from the Morgan Welch Inflammatory Breast Cancer Research Program 10th Anniversary Conference

Naoto T. Ueno^1✉*, Jose Rodrigo Espinosa Fernandez^1*, Massimo Cristofanilli², Beth Overmoyer³, Dan Rea⁴, Fedor Berdichevski⁴, Mohamad El-Shinawi⁵, Jennifer Bellon⁶, Huong T. Le-Petross¹, Anthony Lucci¹, Gildy Babiera¹, Sarah M. DeSnyder¹, Mediget Teshome¹, Edward Chang¹, Bora Lim¹, Savitri Krishnamurthy¹, Michael C Stauder¹, Simrit Parmar⁶, Mona M Mohamed⁷, Angela Alexander¹, Vicente Valero¹, Wendy A. Woodward^1✉

1. Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
2. Department of Medicine, Division of Hematology and Oncology, Robert H Lurie Comprehensive Cancer Center, Northwestern University, Evanston, Illinois, USA
3. Susan F. Smith Center for Women's Cancers, Dana-Farber Cancer Institute, Boston, Massachusetts, USA
4. School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham, UK
5. Department of General Surgery, Faculty of Medicine, Ain Shams University, Cairo, Egypt
6. Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
7. Department of Zoology, Faculty of Science, Cairo University, Giza, Egypt
^* Equal first authors.

✉ Corresponding author: Naoto T. Ueno, M.D., Ph.D., F.A.C.P., Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, Department of Breast Medical Oncology, Unit 1354, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, Texas 77030. Phone: 713-792-8754; E-mail: nuenoorg. Wendy A. Woodward, M.D., Ph.D., Associate Professor of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Box 1202, 1515 Holcombe Blvd, Houston, TX 77030; Fax: (713) 563-6940; E-mail: wwoodwardorg. More

Abstract

National and international experts in inflammatory breast cancer (IBC) from high-volume centers treating IBC recently convened at the 10th Anniversary Conference of the Morgan Welch Inflammatory Breast Cancer Research Program at The University of Texas MD Anderson Cancer Center in Houston Texas. A consensus on the clinical management of patients with IBC was discussed, summarized, and subsequently reviewed. All participants at the conference (patients, advocates, researchers, trainees, and clinicians) were queried using the MDRing electronic survey on key management issues. A summary of the expert consensus and participant voting is presented. Bilateral breast and nodal evaluation, breast magnetic resonance imaging, positron emission tomography/computed tomography, and medical photographs were endorsed as optimal. Neoadjuvant systemic therapy, modified radical mastectomy and level I and II ipsilateral axillary node dissection, post-mastectomy radiotherapy, adjuvant targeted therapy and hormonal therapy as indicated, and delayed reconstruction were agreed-upon fundamental premises of standard non-protocol-based treatment for IBC. Consideration for local-regional therapy in de novo stage IV IBC was endorsed to provide local control whenever feasible. Variation across centers and special circumstances were discussed.

Keywords: inflammatory breast cancer, management, BCS, radiation, mastectomy, neoadjuvant chemotherapy.

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