J Cancer 2018; 9(17):3129-3137. doi:10.7150/jca.25376 This issue


Mesenchymal Stem Cell Derived Exosomes in Cancer Progression, Metastasis and Drug Delivery: A Comprehensive Review

Jingyi Zhou1*, Xiaohong Tan2*, Yiheng Tan1, Qiuyu Li1, Jianjun Ma1✉, Gangyang Wang3✉

1. Human Anatomy Laboratory, School of Basic Medicine, Xinxiang Medical University, Henan, 453003, China
2. The Third Affiliated Hospital of Xinxiang Medical University, Henan,453003, China
3. Department of Orthopaedics, Shanghai Bone Tumor Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China
*These authors have contributed equally to this work

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Zhou J, Tan X, Tan Y, Li Q, Ma J, Wang G. Mesenchymal Stem Cell Derived Exosomes in Cancer Progression, Metastasis and Drug Delivery: A Comprehensive Review. J Cancer 2018; 9(17):3129-3137. doi:10.7150/jca.25376. Available from https://www.jcancer.org/v09p3129.htm

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With the development of cancer treatments, it has become a popular research focus that mesenchymal stem (or stromal) cells (MSCs) have the functional mechanisms that influence cancer progression. One of the underestimated mechanisms is secretion of highly specialized double-membrane structures called exosomes. Mesenchymal stem cells generate several exosomes that may act as paracrine mediators by exchanging genetic information. MSC-derived exosomes are microvesicles ranging from approximately 60-200 nm in size and detected in various body fluids. It has been demonstrated that MSC-derived exosomes are involved in tumor growth, angiogenesis, metastasis, and invasion. Furthermore, emerging evidence suggests that as natural nanocarriers, MSC-exosomes are responsible for multidrug resistance mechanisms, reverse effect of radiation injury, and immune regulation, which can be used in clinical applications for cancer therapy. The present review aims to briefly describe the properties and biological functions of MSC-exosomes in cancer progression and its possible clinical applications in the future.

Keywords: Mesenchymal stem cell, exosomes, cancer therapy