Classification of Solitary Plasmacytoma, Is it more Intricate than Presently Suggested? A Commentary

Nissim Ohana^1*, Ory Rouvio^2*, Karen Nalbandyan³, Dimitri Sheinis¹, Daniel Benharroch^3✉

1. Orthopedic Surgery, Soroka University Medical Center and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel. Present Address: Orthopaedics, Meir Medical Center, Kfar-Saba, Affiliated to Tel-Aviv University, Israel.
2. Hematology Division, Soroka University Medical Center and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel.
3. Hematopathology Service, Pathology Department, Soroka Univ. Med. Ctr. and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel.
* Similar contribution.

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Citation:
Ohana N, Rouvio O, Nalbandyan K, Sheinis D, Benharroch D. Classification of Solitary Plasmacytoma, Is it more Intricate than Presently Suggested? A Commentary. J Cancer 2018; 9(21):3894-3897. doi:10.7150/jca.26854. Available from https://www.jcancer.org/v09p3894.htm

Abstract

A query regarding the definition and the classification of solitary plasmacytoma is apparently still pending. The clinical course, the response to treatment and the propensity to progress to plasma cell myeloma, are all a function of the classification which must be established on a firm basis. Solitary plasmacytoma should be recognized in the continuum of the plasma cell neoplasms. Moreover, whether the solitary plasmacytoma of bone and the extramedullary type of the tumor represent two distinct disease entities, exhibiting separate biological characteristics, has not been finally established. To appraise the similarities and differences between these two types of lesion, we have scrutinized recent investigations relating their classification. A commentary highlighting our conclusions follows.

Keywords: solitary plasmacytoma, solitary plasmacytoma of bone, occult bone marrow disease