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J Cancer 2019; 10(1):105-111. doi:10.7150/jca.27633 This issue Cite

Review

Tuning the Protein Phosphorylation by Receptor Type Protein Tyrosine Phosphatase Epsilon (PTPRE) in Normal and Cancer Cells

Jinping Liang1,2, Jun Shi1, Na Wang1, Hui Zhao3, Jianmin Sun1,4✉

1. School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, P.R.China
2. Ningxia Key laboratory of Clinical and Pathogenic Microbiology, The General Hospital of Ningxia Medical University, Yinchuan, China
3. School of Biomedical Science, Faculty of Medicine, the Chinese University of Hong Kong,
4. Division of Translational Cancer Research, Lund Stem Cell Center, Department of Laboratory Medicine, Lund University, Lund, Sweden

✉ Corresponding author: Jianmin Sun, No. 1160 Shengli Street, Yinchuan 750004, P.R.China jianmin.sunlu.se, jianmin.sunedu.cn, telephone: +86-9516880676, +46-462226451

Citation:
Liang J, Shi J, Wang N, Zhao H, Sun J. Tuning the Protein Phosphorylation by Receptor Type Protein Tyrosine Phosphatase Epsilon (PTPRE) in Normal and Cancer Cells. J Cancer 2019; 10(1):105-111. doi:10.7150/jca.27633. https://www.jcancer.org/v10p0105.htm
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Abstract

Tyrosine phosphorylation is an important post-translation modification of proteins that is controlled by tyrosine kinases and phosphatases. Disruption of the balance between the activity of tyrosine kinases and phosphatases may result in diseases. Receptor type protein tyrosine phosphatase epsilon (PTPRE) is closely related with receptor type protein tyrosine phosphatase alpha (PTPRA). PTPRE has been studied in osteoclast cells, nerve cells, hematopoietic cells, cancer cells and others, and it has different functions among various tissues. In this review, we summarized the current knowledge about the regulation of PTPRE on cellular signal transduction and its function under normal and pathological conditions.

Keywords: tyrosine phosphatase, PTPRE, signaling, cancer

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APA
Liang, J., Shi, J., Wang, N., Zhao, H., Sun, J. (2019). Tuning the Protein Phosphorylation by Receptor Type Protein Tyrosine Phosphatase Epsilon (PTPRE) in Normal and Cancer Cells. Journal of Cancer, 10(1), 105-111. https://doi.org/10.7150/jca.27633.

ACS
Liang, J.; Shi, J.; Wang, N.; Zhao, H.; Sun, J. Tuning the Protein Phosphorylation by Receptor Type Protein Tyrosine Phosphatase Epsilon (PTPRE) in Normal and Cancer Cells. J. Cancer 2019, 10 (1), 105-111. DOI: 10.7150/jca.27633.

NLM
Liang J, Shi J, Wang N, Zhao H, Sun J. Tuning the Protein Phosphorylation by Receptor Type Protein Tyrosine Phosphatase Epsilon (PTPRE) in Normal and Cancer Cells. J Cancer 2019; 10(1):105-111. doi:10.7150/jca.27633. https://www.jcancer.org/v10p0105.htm

CSE
Liang J, Shi J, Wang N, Zhao H, Sun J. 2019. Tuning the Protein Phosphorylation by Receptor Type Protein Tyrosine Phosphatase Epsilon (PTPRE) in Normal and Cancer Cells. J Cancer. 10(1):105-111.

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