J Cancer 2019; 10(7):1663-1674. doi:10.7150/jca.28231 This issue Cite

Review

The Expression, Functions, Interactions and Prognostic Values of PTPRZ1: A Review and Bioinformatic Analysis

Zhenkun Xia1#, Dengjie Ouyang2#, Qianying Li2, Moyun Li2, Qiongyan Zou2, Lun Li3*✉, Wenjun Yi2*✉, Enxiang Zhou2

1. Department of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, China;
2. Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha, China;
3. Department of Breast Surgery, Shanghai Cancer Center, Fudan University, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
# Both authors contributed equally.
* Both authors contributed equally.

Citation:
Xia Z, Ouyang D, Li Q, Li M, Zou Q, Li L, Yi W, Zhou E. The Expression, Functions, Interactions and Prognostic Values of PTPRZ1: A Review and Bioinformatic Analysis. J Cancer 2019; 10(7):1663-1674. doi:10.7150/jca.28231. https://www.jcancer.org/v10p1663.htm
Other styles

File import instruction

Abstract

Available studies demonstrate that receptor-type tyrosine-protein phosphatase zeta (PTPRZ1) is expressed in different tumor tissues, and functions in cell proliferation, cell adhesion and migration, epithelial-to-mesenchymal transition, cancer stem cells and treatment resistance by interacting with or binding to several molecules. These included pleiotrophin (PTN), midkine, interleukin-34, β-catenin, VEGF, NF-κB, HIF-2, PSD-95, MAGI-3, contactin and ErbB4. PTPRZ1 was involved in survival signaling and could predict the prognosis of several tumors. This review discusses: the current knowledge about PTPRZ1, its expression, co-receptors, ligands, functions, signaling pathway, prognostic values and therapeutic agents that target PTPRZ1.

Keywords: PTPRZ1, pleiotrophin, midkine, review


Citation styles

APA
Xia, Z., Ouyang, D., Li, Q., Li, M., Zou, Q., Li, L., Yi, W., Zhou, E. (2019). The Expression, Functions, Interactions and Prognostic Values of PTPRZ1: A Review and Bioinformatic Analysis. Journal of Cancer, 10(7), 1663-1674. https://doi.org/10.7150/jca.28231.

ACS
Xia, Z.; Ouyang, D.; Li, Q.; Li, M.; Zou, Q.; Li, L.; Yi, W.; Zhou, E. The Expression, Functions, Interactions and Prognostic Values of PTPRZ1: A Review and Bioinformatic Analysis. J. Cancer 2019, 10 (7), 1663-1674. DOI: 10.7150/jca.28231.

NLM
Xia Z, Ouyang D, Li Q, Li M, Zou Q, Li L, Yi W, Zhou E. The Expression, Functions, Interactions and Prognostic Values of PTPRZ1: A Review and Bioinformatic Analysis. J Cancer 2019; 10(7):1663-1674. doi:10.7150/jca.28231. https://www.jcancer.org/v10p1663.htm

CSE
Xia Z, Ouyang D, Li Q, Li M, Zou Q, Li L, Yi W, Zhou E. 2019. The Expression, Functions, Interactions and Prognostic Values of PTPRZ1: A Review and Bioinformatic Analysis. J Cancer. 10(7):1663-1674.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.