J Cancer 2019; 10(8):1833-1845. doi:10.7150/jca.29471 This issue

Research Paper

Pro-oncogene Pokemon Promotes Prostate Cancer Progression by Inducing STRN4 Expression

Fuquan Jiang1, Qingfan Zheng1, Liping Chang2, Xu Li1, Xinsheng Wang3✉, Xinquan Gu1✉

1. Department of Urology, China-Japan Union Hospital of Jilin University, Jilin, China
2. The First Affiliated Hospital, Changchun University of Chinese Traditional Medicine, Jilin, China
3. Department of Urology, Tianjin First Center Hospital, Tianjin, China

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Citation:
Jiang F, Zheng Q, Chang L, Li X, Wang X, Gu X. Pro-oncogene Pokemon Promotes Prostate Cancer Progression by Inducing STRN4 Expression. J Cancer 2019; 10(8):1833-1845. doi:10.7150/jca.29471. Available from https://www.jcancer.org/v10p1833.htm

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Abstract

Pokemon, also known as leukemia/lymphoma-related factor (LRF) is a pro-oncogenic protein highly expressed in several cancers. There have been few in vitro and animal studies about its malignant biological behavior and function, however, its role especially in prostate cancer has not been completely elucidated. Therefore, in this study, we identified that Pokemon is overexpressed in human prostate cancer tissue samples, and its suppression inhibits proliferation of prostate cancer cells, along with promotion of apoptosis. Furthermore, to explore the mechanism by which Pokemon promotes tumor progression, we observed that it binds to the promoter of STRN4 (striatin 4), a downstream target, and subsequently regulates its expression. In conclusion, our study indicated that Pokemon through stimulation of STRN4 expression promotes prostate tumor progression via a Pokemon /STRN4 axis.

Keywords: Pokemon, STRN4, prostate cancer, proliferation, apoptosis