Role of IDO and TDO in Cancers and Related Diseases and the Therapeutic Implications

Ye, Zixiang; Yue, Linxiu; Shi, Jiachen; Shao, Mingmei; Wu, Tao

doi:10.7150/jca.31727



International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

Nanotheranostics

Global reach, higher impact

Full Text | PDF

J Cancer 2019; 10(12):2771-2782. doi:10.7150/jca.31727 This issue Cite

Review

Role of IDO and TDO in Cancers and Related Diseases and the Therapeutic Implications

Zixiang Ye, Linxiu Yue, Jiachen Shi, Mingmei Shao, Tao Wu^✉

Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

Citation:

Ye Z, Yue L, Shi J, Shao M, Wu T. Role of IDO and TDO in Cancers and Related Diseases and the Therapeutic Implications. J Cancer 2019; 10(12):2771-2782. doi:10.7150/jca.31727. https://www.jcancer.org/v10p2771.htm

Other styles

Abstract

Kynurenine (Kyn) pathway is a significant metabolic pathway of tryptophan (Trp). The metabolites of the Kyn pathway are closely correlated with numerous diseases. Two main enzymes, indoleamine-2,3-dioxygenase (IDO) and tryptophan-2,3-dioxygenase (TDO or TDO2), regulate the first and rate-limiting step of the Kyn pathway. These enzymes are directly or indirectly involved in various diseases, including inflammatory diseases, cancer, diabetes, and mental disorders. Presently, an increasing number of potential mechanisms have been revealed. In the present review, we depict the structure of IDO and TDO and explicate their functions in various diseases to facilitate a better understanding of them and to indicate new therapeutic plans to target them. Moreover, we summarize the inhibitors of IDO/TDO that are currently under development and their efficacy in the treatment of cancer and other diseases.

Keywords: Tryptophan, Kynurenine, IDO, TDO

Citation styles

APA

Ye, Z., Yue, L., Shi, J., Shao, M., Wu, T. (2019). Role of IDO and TDO in Cancers and Related Diseases and the Therapeutic Implications. Journal of Cancer, 10(12), 2771-2782. https://doi.org/10.7150/jca.31727.

ACS

Ye, Z.; Yue, L.; Shi, J.; Shao, M.; Wu, T. Role of IDO and TDO in Cancers and Related Diseases and the Therapeutic Implications. J. Cancer 2019, 10 (12), 2771-2782. DOI: 10.7150/jca.31727.

NLM

CSE

Ye Z, Yue L, Shi J, Shao M, Wu T. 2019. Role of IDO and TDO in Cancers and Related Diseases and the Therapeutic Implications. J Cancer. 10(12):2771-2782.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.