J Cancer 2019; 10(15):3444-3449. doi:10.7150/jca.33063 This issue

Short Research Communication

Association of the TP53 rs1042522 C>G polymorphism and hepatoblastoma risk in Chinese children

Tianyou Yang1, Yang Wen2, Jiahao Li1, Jiliang Yang1, Tianbao Tan1, Jing Pan1, Chao Hu1, Jiao Zhang3, Yijuan Xin4, Suhong Li5, Huimin Xia1, Jing He1,✉, Yan Zou1,✉

1. Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China
2. First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, Guangdong, China
3. Department of Pediatric Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China
4. Clinical Laboratory Medicine Center of PLA, Xijing Hospital, Air Force Medical University, Xi'an 710032, Shaanxi, China
5. Department of Pathology, Children Hospital and Women Health Center of Shanxi, Taiyuan 030013, Shannxi, China

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Yang T, Wen Y, Li J, Yang J, Tan T, Pan J, Hu C, Zhang J, Xin Y, Li S, Xia H, He J, Zou Y. Association of the TP53 rs1042522 C>G polymorphism and hepatoblastoma risk in Chinese children. J Cancer 2019; 10(15):3444-3449. doi:10.7150/jca.33063. Available from https://www.jcancer.org/v10p3444.htm

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The TP53 gene encodes an important class of cell cycle and tumor-suppressing factors that play critical roles in maintaining genomic stability. The TP53 Arg72Pro (rs1042522 C>G) polymorphism has been reported to be associated with the risk of several types of adult cancers; however, its risk for pediatric cancers remains unclear. Here, we analyzed the association of the TP53 gene rs1042522 C>G polymorphism with hepatoblastoma (HB) susceptibility in a hospital-based study among Chinese children. A total of 213 HB patients and 958 healthy controls were enrolled in the study. Genotypes were determined by a TaqMan assay, and the strength of the association was assessed by the odds ratios and 95% confidence intervals generated from logistic regression models, adjusted for age, gender, and clinical stage. No significant association between the TP53 rs1042522 C>G polymorphism and HB susceptibility was detected in the main analysis or in stratification analyses of age, gender, and clinical stages. Overall, the TP53 gene rs1042522 C>G polymorphism is not associated with HB susceptibility in the Chinese population, other polymorphisms alone or in combination should be investigated to further clarify HB susceptibility.

Keywords: TP53, rs1042522 C>G, polymorphism, genetic association, hepatoblastoma