A medicinal and edible formula YH0618 ameliorates the toxicity induced by Doxorubicin via regulating the expression of Bax/Bcl-2 and FOXO4

You, Jieshu; Gao, Fei; Tang, Hailin; Peng, Fu; Jia, Lei; Huang, Kun; Chow, Kinlong; Zhao, Jiaqi; Liu, Huanlan; Lin, Yi; Chen, Jianping

doi:10.7150/jca.32754

International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

Nanotheranostics

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J Cancer 2019; 10(16):3665-3677. doi:10.7150/jca.32754 This issue Cite

Research Paper

A medicinal and edible formula YH0618 ameliorates the toxicity induced by Doxorubicin via regulating the expression of Bax/Bcl-2 and FOXO4

Jieshu You^1,2, Fei Gao², Hailin Tang³, Fu Peng², Lei Jia², Kun Huang⁴, Kinlong Chow², Jiaqi Zhao^2,5, Huanlan Liu¹, Yi Lin⁶, Jianping Chen^2✉

1. Basic Medical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China.
2. School of Chinese Medicine, The University of Hong Kong, Hong Kong, China.
3. Galactophore Department, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong Province, China.
4. School of Biological Science, The University of Hong Kong, Hong Kong, China.
5. College of pharmacy, Chengdu University of Chinese Medicine, Chengdu, Sichuan Province, China.
6. Galactophore Department, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong Province, China.

Citation:

You J, Gao F, Tang H, Peng F, Jia L, Huang K, Chow K, Zhao J, Liu H, Lin Y, Chen J. A medicinal and edible formula YH0618 ameliorates the toxicity induced by Doxorubicin via regulating the expression of Bax/Bcl-2 and FOXO4. J Cancer 2019; 10(16):3665-3677. doi:10.7150/jca.32754. https://www.jcancer.org/v10p3665.htm

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Abstract

Chemotherapy is the most common and powerful cancer treatment. Although the nasty side effects seriously influence the clinical practice, no better ways can displace it. Therefore, searching for safe and effective strategies designed to ameliorate chemotherapy-induced toxicity has become an urgent issue in cancer research area. In clinical, a medicinal and edible formula YH0618 showed the effects of reducing the DOX-induced toxicity, especially improving alopecia, nail discoloration, skin hyperpigmentation and fatigue. This study was to investigate the role and mechanism of YH0618 in ameliorating DOX-induced toxicity by in vitro and in vivo experiments. YH0618 selectively attenuated DOX-induced growth inhibition and apoptosis in human normal liver L02 cells and kidney HEK-293 cells, and simultaneously potentiated the anti-cancer effect of DOX in breast cancer MCF-7 and MDA-MB-231 cells by apoptosis pathways. Western blotting results revealed that YH0618 attenuated DOX-induced apoptosis in normal liver and kidney cells through FOXO4-mediated mitochondria-dependent mechanism. Animal experiments demonstrated that, YH0618 did not interfere in DOX-induced reduction in tumor volume and significantly improved DOX-induced hair loss and the increase of alanine aminotransferase (ALT). Histological characteristics showed that YH0618 attenuated DOX-induced heart, liver and kidney damage. The study may shed light on the potential application of YH0618 as a novel medicinal food against chemotherapy-induced toxicity.

Keywords: Medicine and food homology, YH0618, DOX-induced toxicity, Apoptosis, Bcl-2/Bax, FOXO4

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APA

You, J., Gao, F., Tang, H., Peng, F., Jia, L., Huang, K., Chow, K., Zhao, J., Liu, H., Lin, Y., Chen, J. (2019). A medicinal and edible formula YH0618 ameliorates the toxicity induced by Doxorubicin via regulating the expression of Bax/Bcl-2 and FOXO4. Journal of Cancer, 10(16), 3665-3677. https://doi.org/10.7150/jca.32754.

ACS

You, J.; Gao, F.; Tang, H.; Peng, F.; Jia, L.; Huang, K.; Chow, K.; Zhao, J.; Liu, H.; Lin, Y.; Chen, J. A medicinal and edible formula YH0618 ameliorates the toxicity induced by Doxorubicin via regulating the expression of Bax/Bcl-2 and FOXO4. J. Cancer 2019, 10 (16), 3665-3677. DOI: 10.7150/jca.32754.

NLM

CSE

You J, Gao F, Tang H, Peng F, Jia L, Huang K, Chow K, Zhao J, Liu H, Lin Y, Chen J. 2019. A medicinal and edible formula YH0618 ameliorates the toxicity induced by Doxorubicin via regulating the expression of Bax/Bcl-2 and FOXO4. J Cancer. 10(16):3665-3677.

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