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J Cancer 2019; 10(24):5975-5985. doi:10.7150/jca.35527 This issue Cite

Research Paper

Long-term Results of Conversion Therapy for Initially Unresectable Gastric Cancer: Analysis of 122 Patients at the National Cancer Center in China

Tongbo Wang1, Nianchang Wang1, Hu Ren1, Hong Zhou1, Aiping Zhou2, Jing Jin3, Yingtai Chen1✉, Dongbing Zhao1✉

1. Department of Pancreatic and Gastric Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
2. Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
3. Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

✉ Corresponding author: Yingtai Chen, MD. & PhD. Phone:+8618600258827 Email: yingtaichencom. Dongbing Zhao, MD. & PhD. Mobile: +8613901331816 Email: dbzhaoac.cn Department of Pancreatic and Gastric Surgical Oncology, National Canc More

Citation:
Wang T, Wang N, Ren H, Zhou H, Zhou A, Jin J, Chen Y, Zhao D. Long-term Results of Conversion Therapy for Initially Unresectable Gastric Cancer: Analysis of 122 Patients at the National Cancer Center in China. J Cancer 2019; 10(24):5975-5985. doi:10.7150/jca.35527. https://www.jcancer.org/v10p5975.htm
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Abstract

Purpose: To assess the long-term survival and prognostic factors of conversion therapy in patients with initially unresectable gastric cancer.

Patients and methods: We conducted a retrospective study of clinicopathological and survival data of 122 consecutive patients who were diagnosed with initially unresectable gastric cancer and underwent the conversion surgery after systemic chemotherapy at the China National Cancer Center between May 2006 and May 2017.

Results: For all the 122 patients, the 3- and 5-year overall survival (OS) rates from the date of chemotherapy initiation were 61.0% and 52.0%, respectively, with a median OS of 63.6 months. During follow-up, the recurrence was observed in 49 (40.1%) patients who underwent conversion surgery. According to the multivariate COX regression analysis, receipt of postoperative adjuvant chemotherapy (POAC) was the only significant independent predictor of a favorable OS (HR 0.40; 95% CI 0.18-0.85, P=0.017). Log-rank analysis showed that POAC group experienced a survival advantage in terms of PFS when compared with observation group (HR 0.53, 95%CI 0.31-0.92, P=0.009).

Conclusions: Conversion therapy may provide long-term survival for patients with initially unresectable gastric cancer. Postoperative adjuvant chemotherapy might be recommended for patients who underwent conversion therapy.

Keywords: Gastric cancer, Conversion therapy, Adjuvant chemotherapy, Unrespectable gastric cancer, Conversion surgery, Chemotherapy

Citation styles

APA
Wang, T., Wang, N., Ren, H., Zhou, H., Zhou, A., Jin, J., Chen, Y., Zhao, D. (2019). Long-term Results of Conversion Therapy for Initially Unresectable Gastric Cancer: Analysis of 122 Patients at the National Cancer Center in China. Journal of Cancer, 10(24), 5975-5985. https://doi.org/10.7150/jca.35527.

ACS
Wang, T.; Wang, N.; Ren, H.; Zhou, H.; Zhou, A.; Jin, J.; Chen, Y.; Zhao, D. Long-term Results of Conversion Therapy for Initially Unresectable Gastric Cancer: Analysis of 122 Patients at the National Cancer Center in China. J. Cancer 2019, 10 (24), 5975-5985. DOI: 10.7150/jca.35527.

NLM
Wang T, Wang N, Ren H, Zhou H, Zhou A, Jin J, Chen Y, Zhao D. Long-term Results of Conversion Therapy for Initially Unresectable Gastric Cancer: Analysis of 122 Patients at the National Cancer Center in China. J Cancer 2019; 10(24):5975-5985. doi:10.7150/jca.35527. https://www.jcancer.org/v10p5975.htm

CSE
Wang T, Wang N, Ren H, Zhou H, Zhou A, Jin J, Chen Y, Zhao D. 2019. Long-term Results of Conversion Therapy for Initially Unresectable Gastric Cancer: Analysis of 122 Patients at the National Cancer Center in China. J Cancer. 10(24):5975-5985.

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