J Cancer 2019; 10(25):6358-6363. doi:10.7150/jca.37564 This issue

Research Paper

H19 gene polymorphisms and neuroblastoma susceptibility in Chinese children: a six-center case-control study

Yong Li1, Zhen-Jian Zhuo2, Haiyan Zhou3, Jiabin Liu2, Jiao Zhang4, Jiwen Cheng5, Haixia Zhou6, Suhong Li7, Ming Li1, Jun He1, Zhenghui Xiao8, Jing He2✉, Yaling Xiao1✉

1. Department of Pediatric Surgery, Hunan Children's Hospital, Changsha 410004, Hunan, China.
2. Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China.
3. Department of Pathology, Xiang-ya School of Medicine, Central South University, Changsha 410013, Hunan, China.
4. Department of Pediatric Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China.
5. Department of Pediatric Surgery, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi, China.
6. Department of Hematology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang, China.
7. Department of Pathology, Children Hospital and Women Health Center of Shanxi, Taiyuan 030013, Shannxi, China.
8. Emergency center of Hunan Children's Hospital, Changsha 410004, Hunan, China.

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Li Y, Zhuo ZJ, Zhou H, Liu J, Zhang J, Cheng J, Zhou H, Li S, Li M, He J, Xiao Z, He J, Xiao Y. H19 gene polymorphisms and neuroblastoma susceptibility in Chinese children: a six-center case-control study. J Cancer 2019; 10(25):6358-6363. doi:10.7150/jca.37564. Available from https://www.jcancer.org/v10p6358.htm

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Neuroblastoma is the most common seen solid tumor in children less than one year old. Given that polymorphisms in the lncRNA H19 gene are observed in several types of human malignancies, there likely to be similar events that contribute to the pathogenesis of neuroblastoma. We hypothesize that single nucleotide polymorphisms (SNPs) in the H19 gene might predispose to neuroblastoma. Here, we genotyped three SNPs (rs2839698 G>A, rs3024270 C>G, rs217727 G>A) from H19 gene in a Chinese population (700 subjects with neuroblastoma and 1516 control subjects) enrolled from six hospitals and examined the effect of individual and combined SNPs on the risk of neuroblastoma. Odds ratios (ORs) and 95% confidence intervals (CIs) calculated from logistic regression were adopted to assess such association, adjusted for age and gender. Among them, 700 controls and 1514 cases were successfully genotyped. None of these three SNPs were found to be relevant to the risk of neuroblastoma, either in overall analysis or stratification analysis. Findings from this study excluded the participation of lncRNA H19 gene SNPs in the risk of neuroblastoma. More independent case-control studies are encouraged to better elucidate this relationship.

Keywords: lncRNA, H19, polymorphism, neuroblastoma, susceptibility