Association between gene methylation and HBV infection in hepatocellular carcinoma: A meta-analysis

Zhang, Cheng; Huang, Changxin; Sui, Xinbing; Zhong, Xueqing; Yang, Wenjun; Hu, Xiangrong; Li, Yongqiang

doi:10.7150/jca.33005

International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

Nanotheranostics

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J Cancer 2019; 10(25):6457-6465. doi:10.7150/jca.33005 This issue Cite

Research Paper

Association between gene methylation and HBV infection in hepatocellular carcinoma: A meta-analysis

Cheng Zhang^1✉, Changxin Huang¹, Xinbing Sui¹, Xueqing Zhong², Wenjun Yang³, Xiangrong Hu³, Yongqiang Li^1,4✉

1. Department of Medical Oncology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China
2. Department of Gastroenterology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China
3. Department of Pathology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China
4. Key Laboratory of Elemene Class Anti-cancer Chinese Medicine of Zhejiang Province, Hangzhou, Zhejiang, China

Citation:

Zhang C, Huang C, Sui X, Zhong X, Yang W, Hu X, Li Y. Association between gene methylation and HBV infection in hepatocellular carcinoma: A meta-analysis. J Cancer 2019; 10(25):6457-6465. doi:10.7150/jca.33005. https://www.jcancer.org/v10p6457.htm

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Abstract

Gene methylation is an epigenetic alteration in hepatocellular carcinoma (HCC), and hepatitis B virus (HBV) plays a crucial role in carcinogenesis of HCC. However, the association between gene methylation and HBV infection in HCC remains unclear. In our study, we conducted a comprehensive meta-analysis to evaluate the association. A total of 1,148 studies were initially retrieved from some literature database. After a four-step filtration, we obtained 69 case-control studies in this meta-analysis. Our results showed six genes (p16, RASSF1A, GSTP1, APC, p15 and SFRP1) in HBV-positive carcinoma tissues, one gene (GSTP1) in HBV-positive adjacent tissues and two gene (p16 and APC) in HBV-positive carcinoma serums, which were significantly hypermethylated. Subgroup meta-analysis by geographical populations revealed that GSTP1 methylation was significantly higher in HBV-positive carcinoma tissues in China and Japan. In addition, p16 and RASSF1A methylation was significantly higher in China but not in Japan. Our study indicated that HBV infection could induce DNA methylation in HCC and DNA methylation could lead to the development of HBV-related HCC.

Keywords: meta-analysis, gene methylation, hepatitis B virus, hepatocellular carcinoma

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APA

Zhang, C., Huang, C., Sui, X., Zhong, X., Yang, W., Hu, X., Li, Y. (2019). Association between gene methylation and HBV infection in hepatocellular carcinoma: A meta-analysis. Journal of Cancer, 10(25), 6457-6465. https://doi.org/10.7150/jca.33005.

ACS

Zhang, C.; Huang, C.; Sui, X.; Zhong, X.; Yang, W.; Hu, X.; Li, Y. Association between gene methylation and HBV infection in hepatocellular carcinoma: A meta-analysis. J. Cancer 2019, 10 (25), 6457-6465. DOI: 10.7150/jca.33005.

NLM

CSE

Zhang C, Huang C, Sui X, Zhong X, Yang W, Hu X, Li Y. 2019. Association between gene methylation and HBV infection in hepatocellular carcinoma: A meta-analysis. J Cancer. 10(25):6457-6465.

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