KIAA1211 plays an oncogenic role in human non-small cell lung cancer

Liu, Zhengcheng; Cao, Hui; Shi, Ye; Yang, Rusong

doi:10.7150/jca.35951



International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

Nanotheranostics

Global reach, higher impact

Full Text | PDF

J Cancer 2019; 10(26):6747-6753. doi:10.7150/jca.35951 This issue Cite

Research Paper

KIAA1211 plays an oncogenic role in human non-small cell lung cancer

Zhengcheng Liu, Hui Cao, Ye Shi, Rusong Yang^✉

Department of Thoracic Surgery, Nanjing Chest Hospital, Nanjing, Jiangsu, 210000, China

Citation:

Liu Z, Cao H, Shi Y, Yang R. KIAA1211 plays an oncogenic role in human non-small cell lung cancer. J Cancer 2019; 10(26):6747-6753. doi:10.7150/jca.35951. https://www.jcancer.org/v10p6747.htm

Other styles

Abstract

One of the main causes of cancer disease and death worldwide is lung cancer. Our study focused on the function of KIAA1211 in non-small cell lung cancer (NSCLC). According to the data about NSCLC patients that from the Cancer Genome Atlas (TCGA), we found that KIAA1211 in NSCLC (P=5.06E-06) was significantly higher than the adjacent normal. Lentivirus-mediated short hairpin RNA (shRNA) was used to knockdown BATF expression in the human A549 NSCLC cell line and assessed by RT-qPCR and Western blot. Cell proliferation was evaluated by MTT assay and Celigo imaging cytometry. Cell apoptosis were detected by Annexin V staining. The test results showed that KIAA1211-shRNA A549 and SPC-A-1 cells can inhibit cell proliferation, and the apoptosis rate of KIAA1211-shRNA group was significantly higher than that of the control group. Knockdown of KIAA1211 inhibited NSCLC progression in xenograft tumor model. In conclusion, KIAA1211 could regulate NSCLC cells proliferation and apoptosis in vitro and in vivo. KIAA1211 may serve as a potent target for the treatment of NSCLC.

Keywords: KIAA1211, NSCLC, Proliferation, Apoptosis

Citation styles

APA

Liu, Z., Cao, H., Shi, Y., Yang, R. (2019). KIAA1211 plays an oncogenic role in human non-small cell lung cancer. Journal of Cancer, 10(26), 6747-6753. https://doi.org/10.7150/jca.35951.

ACS

Liu, Z.; Cao, H.; Shi, Y.; Yang, R. KIAA1211 plays an oncogenic role in human non-small cell lung cancer. J. Cancer 2019, 10 (26), 6747-6753. DOI: 10.7150/jca.35951.

NLM

Liu Z, Cao H, Shi Y, Yang R. KIAA1211 plays an oncogenic role in human non-small cell lung cancer. J Cancer 2019; 10(26):6747-6753. doi:10.7150/jca.35951. https://www.jcancer.org/v10p6747.htm

CSE

Liu Z, Cao H, Shi Y, Yang R. 2019. KIAA1211 plays an oncogenic role in human non-small cell lung cancer. J Cancer. 10(26):6747-6753.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.