J Cancer
2019; 10(27):6813-6821.
doi:10.7150/jca.35489 This issueCite
Research Paper
Systematic Identification of Multi Omics-based Biomarkers in KEAP1 Mutated TCGA Lung Adenocarcinoma
Akhileshwar Namani1, Zhaohong Zheng2, Xiu Jun Wang2, Xiuwen Tang1✉
1. Department of Thoracic Surgery and Department of Biochemistry of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, PR China; 2. Department of Pharmacology, and Cancer Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, PR China.
✉ Corresponding author: Xiuwen Tang, Department of Thoracic Surgery and Department of Biochemistry of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, PR China, Tel: +0086-(0)571-88981270, Fax: +0086-(0)571-88208266, E-mail: xiuwentangedu.cn.More
Citation:
Namani A, Zheng Z, Wang XJ, Tang X. Systematic Identification of Multi Omics-based Biomarkers in KEAP1 Mutated TCGA Lung Adenocarcinoma. J Cancer 2019; 10(27):6813-6821. doi:10.7150/jca.35489. https://www.jcancer.org/v10p6813.htm
Mutations in KEAP1 and/or NRF2 genes have been identified across many cancers and the dysregulation of the NRF2 pathway due to these mutations leads to drug and radioresistance in several cancers. Identification of biomarkers associated with these mutations allows the researchers and clinicians to identify the personalized medicine and quicker diagnosis. In this current study, we carried out an integrated, multi-omics, multi-database analysis of exome, transcriptomics data's of KEAP1 mutated TCGA- Lung adenocarcinoma (LUAD) patients against non-mutated counterparts. Finally, we discovered the gene signature associated with KEAP1 mutations, prognostic genes which were highly correlated with the upregulation of the NRF2 pathway in the KEAP1 mutated LUAD patients. Our finding might be useful to identify the early diagnosis of KEAP1 mutated LUAD patients.
Namani, A., Zheng, Z., Wang, X.J., Tang, X. (2019). Systematic Identification of Multi Omics-based Biomarkers in KEAP1 Mutated TCGA Lung Adenocarcinoma. Journal of Cancer, 10(27), 6813-6821. https://doi.org/10.7150/jca.35489.
ACS
Namani, A.; Zheng, Z.; Wang, X.J.; Tang, X. Systematic Identification of Multi Omics-based Biomarkers in KEAP1 Mutated TCGA Lung Adenocarcinoma. J. Cancer 2019, 10 (27), 6813-6821. DOI: 10.7150/jca.35489.
NLM
Namani A, Zheng Z, Wang XJ, Tang X. Systematic Identification of Multi Omics-based Biomarkers in KEAP1 Mutated TCGA Lung Adenocarcinoma. J Cancer 2019; 10(27):6813-6821. doi:10.7150/jca.35489. https://www.jcancer.org/v10p6813.htm
CSE
Namani A, Zheng Z, Wang XJ, Tang X. 2019. Systematic Identification of Multi Omics-based Biomarkers in KEAP1 Mutated TCGA Lung Adenocarcinoma. J Cancer. 10(27):6813-6821.
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