Metformin and LW6 impairs pancreatic cancer cells and reduces nuclear localization of YAP1

Zhang, Xianbin; Liu, Peng; Shang, Yuru; Kerndl, Hagen; Kumstel, Simone; Gong, Peng; Vollmar, Brigitte; Zechner, Dietmar

doi:10.7150/jca.33029

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Research Paper

Metformin and LW6 impairs pancreatic cancer cells and reduces nuclear localization of YAP1

Xianbin Zhang^1,2✉, Peng Liu³, Yuru Shang^2,4, Hagen Kerndl¹, Simone Kumstel¹, Peng Gong³, Brigitte Vollmar¹, Dietmar Zechner¹

1. Institute for Experimental Surgery, Rostock University Medical Center, Schillingallee 69a, 18059, Rostock, Germany;
2. Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jiyan Road 440, 250117, Jinan, China;
3. Department of General Surgery, Shenzhen University General Hospital, Xueyuan Road 1098, 518055, Shenzhen, China;
4. Molecular Oncology and Immunotherapy, Department of General Surgery, Rostock University Medical Center, Schillingallee 69, 18059, Rostock, Germany.

Citation:

Zhang X, Liu P, Shang Y, Kerndl H, Kumstel S, Gong P, Vollmar B, Zechner D. Metformin and LW6 impairs pancreatic cancer cells and reduces nuclear localization of YAP1. J Cancer 2020; 11(2):479-487. doi:10.7150/jca.33029. https://www.jcancer.org/v11p0479.htm

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Abstract

The poor survival rate of pancreatic cancer is still a major challenge for the clinicians and their patients. In this study, we evaluated the efficacy of metformin, an inhibitor of oxidative phosphorylation, in combination with LW6, which impairs malate dehydrogenase 2 activities, in treating pancreatic cancer cells. We observed that this combinational therapy significantly reduced cell proliferation, migration, and significantly induced cell death when compared to cells treated by each monotherapy or Sham. In addition, we found that the combination of metformin and LW6 increased the phosphorylation of yes-associated protein 1 at serine 127 and attenuated the nuclear localization of this transcription factor. This combinatorial treatment also decreased the level of cellular yes-associated protein 1. This suggests that metformin in combination with LW6 impairs pancreatic cancer cells and reduces nuclear localization of yes-associated protein 1.

Keywords: Metformin, LW6, YAP1

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APA

Zhang, X., Liu, P., Shang, Y., Kerndl, H., Kumstel, S., Gong, P., Vollmar, B., Zechner, D. (2020). Metformin and LW6 impairs pancreatic cancer cells and reduces nuclear localization of YAP1. Journal of Cancer, 11(2), 479-487. https://doi.org/10.7150/jca.33029.

ACS

Zhang, X.; Liu, P.; Shang, Y.; Kerndl, H.; Kumstel, S.; Gong, P.; Vollmar, B.; Zechner, D. Metformin and LW6 impairs pancreatic cancer cells and reduces nuclear localization of YAP1. J. Cancer 2020, 11 (2), 479-487. DOI: 10.7150/jca.33029.

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CSE

Zhang X, Liu P, Shang Y, Kerndl H, Kumstel S, Gong P, Vollmar B, Zechner D. 2020. Metformin and LW6 impairs pancreatic cancer cells and reduces nuclear localization of YAP1. J Cancer. 11(2):479-487.

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