Department of Radiation Oncology, Guangxi Medical University Cancer Hospital and Cancer Institute of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, P.R. China
✉ Corresponding author: Xiaodong Zhu, Address: Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, No. 71 He Di Road, Nanning 530021, Guangxi, China. Tel.: +86-13978873616; E-mail: zhuxdonggxmucom
Citation:
Liang R, Chen X, Chen L, Wan F, Chen K, Sun Y, Zhu X. STAT3 signaling in ovarian cancer: a potential therapeutic target. J Cancer 2020; 11(4):837-848. doi:10.7150/jca.35011. https://www.jcancer.org/v11p0837.htm
Accumulating evidence has shown that Signal Transducer and Activator of Transcription 3 (STAT3) is thought to be a promising target for cancer therapy as STAT3 is frequently overexpressed in a wide range of cancer cells as well as clinical specimens, promoting tumor progression. It is widely accepted that STAT3 regulates a variety of cellular processes, such as tumor cell growth, survival, invasion, cancer stem cell-like characteristic, angiogenesis and drug-resistance. In this review, we focus on the role of STAT3 in tumorigenesis in ovarian cancer and discuss the existing inhibitors of STAT3 signaling that can be promisingly developed as the strategies for ovarian cancer therapy.
Liang, R., Chen, X., Chen, L., Wan, F., Chen, K., Sun, Y., Zhu, X. (2020). STAT3 signaling in ovarian cancer: a potential therapeutic target. Journal of Cancer, 11(4), 837-848. https://doi.org/10.7150/jca.35011.
ACS
Liang, R.; Chen, X.; Chen, L.; Wan, F.; Chen, K.; Sun, Y.; Zhu, X. STAT3 signaling in ovarian cancer: a potential therapeutic target. J. Cancer 2020, 11 (4), 837-848. DOI: 10.7150/jca.35011.
NLM
Liang R, Chen X, Chen L, Wan F, Chen K, Sun Y, Zhu X. STAT3 signaling in ovarian cancer: a potential therapeutic target. J Cancer 2020; 11(4):837-848. doi:10.7150/jca.35011. https://www.jcancer.org/v11p0837.htm
CSE
Liang R, Chen X, Chen L, Wan F, Chen K, Sun Y, Zhu X. 2020. STAT3 signaling in ovarian cancer: a potential therapeutic target. J Cancer. 11(4):837-848.
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