J Cancer 2020; 11(6):1403-1411. doi:10.7150/jca.31406

Review

The Molecular Mechanism of Metabolic Remodeling in Lung Cancer

Ligong Chang*, Surong Fang*, Wei Gu

Department of Respiratory Medicine, Nanjing First Hospital, Nanjing Medical University. No. 68 Changle Road, Qinhuai District, Nanjing 210001,People's Republic of China.
*LC and SF contributed equally to the work.

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Citation:
Chang L, Fang S, Gu W. The Molecular Mechanism of Metabolic Remodeling in Lung Cancer. J Cancer 2020; 11(6):1403-1411. doi:10.7150/jca.31406. Available from https://www.jcancer.org/v11p1403.htm

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Abstract

Metabolic remodeling is a key phenomenon in the occurrence and development of tumors. It not only offers materials and energy for the survival and proliferation of tumor cells, but also protects tumor cells so that they may survive, proliferate and transfer in the harsh microenvironment. This paper attempts to reveal the role of abnormal metabolism in the development of lung cancer by considering the processes of glycolysis and lipid metabolism, Identification of the molecules that are specifically used in the processes of glycolysis and lipid metabolism, and their underlying molecular mechanisms, is of great clinical and theoretical significance. We will focus on the recent progress in elucidating the molecular mechanism of metabolic remodeling in lung cancer.

Keywords: Lung cancer, Glycolysis, Lipid metabolism, Molecular mechanism