J Cancer 2020; 11(6):1641-1647. doi:10.7150/jca.38856

Research Paper

Effects of MACC1 polymorphisms on hepatocellular carcinoma development and clinical characteristics

Chien-Hua Lin1, Ming-Ju Hsieh2,3,4, Hsiang-Lin Lee5,6, Shun-Fa Yang2,7, Shih-Chi Su8,9, Wei-Jiunn Lee10,11,✉, Ying-Erh Chou2,6,7,✉

1. Department of Surgery, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan
2. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
3. Cancer Research Center, Changhua Christian Hospital, Changhua, Taiwan
4. Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan
5. Department of Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan
6. School of Medicine, Chung Shan Medical University, Taichung, Taiwan
7. Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan
8. Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan
9. Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan
10. Department of Urology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
11. Department of Medical Education and Research, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan

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Citation:
Lin CH, Hsieh MJ, Lee HL, Yang SF, Su SC, Lee WJ, Chou YE. Effects of MACC1 polymorphisms on hepatocellular carcinoma development and clinical characteristics. J Cancer 2020; 11(6):1641-1647. doi:10.7150/jca.38856. Available from https://www.jcancer.org/v11p1641.htm

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Abstract

Hepatocellular carcinoma (HCC) is a major malignancy of cancer-related mortality worldwide. Metastasis-associated in colon cancer-1 (MACC1) was suggested as a marker for vascular invasive HCC. This study investigated the MACC1 single-nucleotide polymorphisms (SNPs) to evaluate HCC susceptibility and clinicopathological characteristics. In this study, real-time polymerase chain reaction was applied to analyze five SNPs of MACC1 rs1990172, rs975263, rs3095007, rs4721888, and rs3735615 in 378 patients with HCC and 1199 cancer-free controls. The results showed that in 151 HCC patients among smokers who carried MACC1 rs1990172 "CA + AA" variants had a lower risk of developing a large tumor (odds ratio [OR] = 0.375, p = 0.026), more advanced clinical stage ([OR] = 0.390, p=0.032), and vascular invasion ([OR] = 0.198, p = 0.034). In 137 HCC patients among drinkers who carried MACC1 rs4721888 "GC + CC" variants had a higher risk to develop vascular invasion ([OR] = 3.780, p = 0.009). Further analyses revealed a statistical significance of aberrant AST/ALT ratio in HCC patients with MACC1 rs975263 "AG+GG" variants before adjustment of age and alcohol drinking. In conclusion, our results suggested that the MACC1 SNPs rs1990172, rs4721888, and rs975263 are involved in HCC progression and clinical characteristics. MACC1 polymorphisms may serve as a marker or a predictor to evaluate HCC progression and prognosis.

Keywords: Hepatocellular carcinoma, polymorphism, MACC1