J Cancer 2020; 11(8):2000-2007. doi:10.7150/jca.40531 This issue

Review

FGF/FGFR signaling pathway involved resistance in various cancer types

Yangyang Zhou1*, Chengyu Wu1*, Guangrong Lu2, Zijing Hu3, Qiuxiang Chen4✉, Xiaojing Du5✉

1. Department of Rheumatology and Immunology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China
2. Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical, Wenzhou, Zhejiang 325000, China)
3. College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China
4. Department of Ultrasonic Imaging, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China
5. Department of Gastroenterology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China
*Yangyang Zhou and Chengyu Wu contributed equally to this work

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Citation:
Zhou Y, Wu C, Lu G, Hu Z, Chen Q, Du X. FGF/FGFR signaling pathway involved resistance in various cancer types. J Cancer 2020; 11(8):2000-2007. doi:10.7150/jca.40531. Available from https://www.jcancer.org/v11p2000.htm

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Abstract

Resistance becomes major clinical issue in cancer treatment, which strongly limits patients to benefit from oncotherapy. Growing evidences have been indicative of the critical role of fibroblast growth factor (FGF)/receptor (FGFR) signaling played in resistance to oncotherapy. In this review we discussed the underlying mechanisms of FGF/FGFR signaling mediated resistance to chemotherapy, radiotherapy and target therapy in various cancers. Meanwhile, we summarized the reported mechanism of FGF/FGFR inhibitors resistance in cancers.

Keywords: FGF/FGFR, resistance, oncotherapy, FGF/FGFR inhibitors