J Cancer 2020; 11(8):2213-2221. doi:10.7150/jca.39800 This issue

Research Paper

High Expression of Cancer-Derived Glycosylated Immunoglobulin G Predicts Poor Prognosis in Pancreatic Ductal Adenocarcinoma

Ming Cui1, Lei You1, Bang Zheng2, Xinmei Huang3,4, Qiaofei Liu1, Jing Huang3,4, Boju Pan5, Xiaoyan Qiu3,4✉, Quan Liao1✉, Yupei Zhao1✉

1. Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
2. School of Public Health, Faculty of Medicine, Imperial College London, London W6 8RP, UK
3. Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China
4. Peking University Center for Human Disease Genomics, Beijing 100191, China
5. Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

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Citation:
Cui M, You L, Zheng B, Huang X, Liu Q, Huang J, Pan B, Qiu X, Liao Q, Zhao Y. High Expression of Cancer-Derived Glycosylated Immunoglobulin G Predicts Poor Prognosis in Pancreatic Ductal Adenocarcinoma. J Cancer 2020; 11(8):2213-2221. doi:10.7150/jca.39800. Available from https://www.jcancer.org/v11p2213.htm

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Abstract

Background: Cancer-derived immunoglobulin G (CIgG) has been detected in various cancers and plays important roles in carcinogenesis. The present study aimed to investigate its clinical significance in pancreatic ductal adenocarcinoma (PDAC).

Methods: Using tissue microarrays (TMAs) and immunohistochemistry, we assessed CIgG expression in 326 patients who underwent surgical resection for PDAC. The associations between CIgG expression and clinicopathological features and clinical outcomes were analyzed. Functional experiments were also performed to investigate the effect of CIgG on PDAC cells.

Results: High CIgG expression was related to poor tumor differentiation and metastasis during follow-up and was associated with poor disease-free survival (DFS) and overall survival (OS). A multivariate Cox regression analysis identified high CIgG expression as an independent prognostic factor for DFS and OS. The incorporation of CIgG expression improved the accuracy of an established prognosis prediction model for 1-year OS and 2-year OS. In vitro studies showed that knocking down CIgG profoundly suppressed the proliferation, migration, and invasion capacity of PDAC cells.

Conclusions: CIgG contributes to the malignant behaviors of PDAC and offers a powerful prognostic predictor for these patients.

Keywords: pancreatic ductal adenocarcinoma, cancer-derived IgG, survival, prognosis