Comprehensive Analysis of the Tumor Microenvironment in Cutaneous Melanoma associated with Immune Infiltration

Wang, Pan; Zhang, Xinyu; Sun, Nan; Zhao, Zhihong; He, Jie

doi:10.7150/jca.44413



International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

Nanotheranostics

Global reach, higher impact

Full Text | PDF

J Cancer 2020; 11(13):3858-3870. doi:10.7150/jca.44413 This issue Cite

Research Paper

Comprehensive Analysis of the Tumor Microenvironment in Cutaneous Melanoma associated with Immune Infiltration

Pan Wang^1,*, Xinyu Zhang^2,*, Nan Sun^1,*, Zhihong Zhao¹, Jie He^1✉

1. Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
2. Department of body contouring and liposuction center, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100144, China
*These authors contributed equally to this work.

Citation:

Wang P, Zhang X, Sun N, Zhao Z, He J. Comprehensive Analysis of the Tumor Microenvironment in Cutaneous Melanoma associated with Immune Infiltration. J Cancer 2020; 11(13):3858-3870. doi:10.7150/jca.44413. https://www.jcancer.org/v11p3858.htm

Other styles

Abstract

Accumulating evidence suggests that the malignant phenotypes of cancers are determined not only by the intrinsic properties of cancer cells but also by components in the tumor microenvironment (TME). In this study, we comprehensively characterized the TME of cutaneous melanoma (CM). As a result, tumor stage, tissue site, ulceration, thickness as well as patient age, sex were associated with immune infiltration. Patients of higher immune infiltration exhibited better survival outcomes, and antitumor effector cells, such as CD8 T cells and M1 macrophages, were found in significantly higher numbers in those tissues. Differential expression of mRNAs and long non-coding RNAs (lncRNAs) was analyzed and utilized to construct an immune-related competing endogenous RNA network, in which a lncRNA-associated subnetwork that could positively regulate the expression of IFN-γ was highlighted. Functional analysis confirmed that this network was remarkably enriched in functional terms related to both immune response and tumor-intrinsic pathways. Finally, a total of 109 high-confidence prognostic genes were identified, and a gene module that contained several key immune checkpoint molecules or modulators (PD-1, PD-L1, PD-L2, and LCK) was screened, which confers survival benefit for CM patients as supported by both overall and relapse-free survival rates from different datasets.

Keywords: cutaneous melanoma, tumor microenvironment, immune infiltration, competing endogenous RNA, prognosis

Citation styles

APA

Wang, P., Zhang, X., Sun, N., Zhao, Z., He, J. (2020). Comprehensive Analysis of the Tumor Microenvironment in Cutaneous Melanoma associated with Immune Infiltration. Journal of Cancer, 11(13), 3858-3870. https://doi.org/10.7150/jca.44413.

ACS

Wang, P.; Zhang, X.; Sun, N.; Zhao, Z.; He, J. Comprehensive Analysis of the Tumor Microenvironment in Cutaneous Melanoma associated with Immune Infiltration. J. Cancer 2020, 11 (13), 3858-3870. DOI: 10.7150/jca.44413.

NLM

CSE

Wang P, Zhang X, Sun N, Zhao Z, He J. 2020. Comprehensive Analysis of the Tumor Microenvironment in Cutaneous Melanoma associated with Immune Infiltration. J Cancer. 11(13):3858-3870.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.