J Cancer 2020; 11(13):3976-3985. doi:10.7150/jca.42734

Review

MiRNAs in Radiotherapy Resistance of Nasopharyngeal Carcinoma

Yutong Tian1,2, Lu Tang1,2, Pin Yi1,2, Qing Pan1,2, Yaqian Han1, Yingrui Shi1, Shan Rao1, Shiming Tan1, Longzheng Xia1, Jinguan Lin1, Linda Oyang1, Yanyan Tang1, Jiaxin Liang1, Xia Luo1, Qianjin Liao1, Hui Wang1✉, Yujuan Zhou1✉

1. The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University and Hunan Cancer Hospital, Key Laboratory of Translational Radiation Oncology, Hunan Province, 283 Tongzipo Road, Changsha 410013, Hunan, China.
2. University of South China, Hengyang, 421001, Hunan, China.

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Citation:
Tian Y, Tang L, Yi P, Pan Q, Han Y, Shi Y, Rao S, Tan S, Xia L, Lin J, Oyang L, Tang Y, Liang J, Luo X, Liao Q, Wang H, Zhou Y. MiRNAs in Radiotherapy Resistance of Nasopharyngeal Carcinoma. J Cancer 2020; 11(13):3976-3985. doi:10.7150/jca.42734. Available from https://www.jcancer.org/v11p3976.htm

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Abstract

Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumors of the head and neck in Southeast Asia and southern China. Although the comprehensive treatment based on intensity-modulated radiation therapy improves outcomes, the five-year survival rate of NPC patients is low, and the recurrence remains high. Radiotherapy resistance is the main cause of poor prognosis in NPC patients. MicroRNAs (miRNAs) are a class of endogenous non-coding RNAs regulating various biological functions in eukaryotes. These miRNAs can regulate the development and progression of nasopharyngeal carcinoma by affecting the proliferation, apoptosis, movement, invasion and metastasis of NPC cells. The abnormal expression of miRNAs is closely related to radiotherapy sensitivity and prognosis of NPC patients, which can affect the transmission of related signaling pathways by regulating the expression of tumor suppressor genes and / or oncogenes, and therefore participate in radiotherapy resistance in nasopharyngeal carcinoma. Here, we review the mechanisms by which miRNAs may be involved in the radiotherapy resistance of nasopharyngeal carcinoma.

Keywords: nasopharyngeal carcinoma, radiotherapy resistance, miRNAs, apoptosis, miR-BARTs